Zobrazeno 1 - 10
of 57
pro vyhledávání: '"T. Breitbach"'
Autor:
Daniela I. Korec, Darian S. Louke, Justin T. Breitbach, Jennifer A. Geisler, Brian D. Husbands, Joelle M. Fenger
Publikováno v:
BMC Veterinary Research, Vol 17, Iss 1, Pp 1-13 (2021)
Abstract Background Urothelial carcinoma (UC) accounts for > 90% of canine tumors occurring in the urinary bladder. Toceranib phosphate (TOC) is a multi-target receptor tyrosine kinase (RTK) inhibitor that exhibits activity against members of the spl
Externí odkaz:
https://doaj.org/article/d4673d8dd2da49ce904434e53d729bb4
Autor:
Justin T. Breitbach, Joelle M. Fenger, Daniela I. Korec, Brian D Husbands, Darian S. Louke, Jennifer A. Geisler
Publikováno v:
BMC Veterinary Research, Vol 17, Iss 1, Pp 1-13 (2021)
BMC Veterinary Research
BMC Veterinary Research
Background Urothelial carcinoma (UC) accounts for > 90% of canine tumors occurring in the urinary bladder. Toceranib phosphate (TOC) is a multi-target receptor tyrosine kinase (RTK) inhibitor that exhibits activity against members of the split kinase
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef9e739772d6f58eb1878d82d54929c5
https://doaj.org/article/d4673d8dd2da49ce904434e53d729bb4
https://doaj.org/article/d4673d8dd2da49ce904434e53d729bb4
Autor:
Alexander E. Davies, M.R. Watts, Justin T. Breitbach, Joelle M. Fenger, Savannah J. Tobin, Darian S. Louke
Publikováno v:
Veterinary and Comparative Oncology
Verdinexor (KPT‐335) is a novel orally bioavailable selective inhibitor of nuclear export (SINE) compound that inhibits the function of the nuclear export protein Exportin 1 (XPO1/CRM1). In the present study, we sought to characterize the expressio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::288d4d5908f12821ec9aaca1e49042f0
http://europepmc.org/articles/PMC8248106
http://europepmc.org/articles/PMC8248106
Autor:
Said M. Elshafae, Thomas J. Rosol, Zayed Attia, Shiyu Yuan, Wessel P. Dirksen, Justin T. Breitbach, Aylin Alasonyalilar-Demirer, Bardes B. Hassan, Lucas B. Alstadt, Noriko Kantake, Wachiraphan Supsavhad
Publikováno v:
Prostate
Background Osteoblastic bone metastasis represents the most common complication in men with prostate cancer (PCa). During progression and bone metastasis, PCa cells acquire properties similar to bone cells in a phenomenon called osteomimicry, which p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1be017d626f06176ed8376d97ea36b01
https://doi.org/10.1002/pros.23983
https://doi.org/10.1002/pros.23983
Publikováno v:
Cancers, Vol 13, Iss 5066, p 5066 (2021)
Cancers
Volume 13
Issue 20
Cancers
Volume 13
Issue 20
Simple Summary Adult T-cell leukemia (ATL) Leukemia is an aggressive, peripheral blood (T-cell) neoplasm associated with human T-cell leukemia virus type 1 (HTLV-1) infection. Recent studies have implicated dysregulated histone deacetylases in ATL pa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c6d9754d7e7453c5d36ab2917eb7ad7
https://www.mdpi.com/2072-6694/13/20/5066
https://www.mdpi.com/2072-6694/13/20/5066
Autor:
Alexander Pan, John C. Byrd, Lianbo Yu, Fabienne Lucas, Zachary A. Hing, Justin T. Breitbach, Parviz Kanga, Rosa Lapalombella, Virginia M. Goettl, Pearlly S. Yan, Ralf Bundschuh, Kerry A. Rogers, Deepa Sampath, Bonnie K. Harrington, Ronni Wasmuth, Lisa L. Smith, Danielle K. White, Jennifer A. Woyach, Rose Mantel
Publikováno v:
Clinical Cancer Research. 25:6260-6273
Purpose:Aberrant Myc expression is a major factor in the pathogenesis of aggressive lymphoma, and these lymphomas, while clinically heterogeneous, often are resistant to currently available treatments and have poor survival. Myc expression can also b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f46e699e92270009865e707b81737c61
https://doi.org/10.1158/1078-0432.ccr-19-0273
https://doi.org/10.1158/1078-0432.ccr-19-0273
Parathyroid hormone-related protein promotes bone loss in T-cell leukemia as well as in solid tumors
Autor:
Justin T. Breitbach, Jingyu Xiang, Sherry T. Shu, Nicole A. Kohart, Said M. Elshafae, Thomas J. Rosol, Wessel P. Dirksen, Katherine N. Weilbaecher, Aylin A. Demirer
Publikováno v:
Leuk Lymphoma
Parathyroid hormone-related protein (PTHrP) and macrophage inflammatory protein-1α (MIP-1α) are important factors that increase bone resorption and hypercalcemia in Adult T-cell Leukemia (ATL). We investigated the role of PTHrP and MIP-1α in the d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2da330305dfc1bfd42fc5640cc974516
https://doi.org/10.1080/10428194.2019.1672055
https://doi.org/10.1080/10428194.2019.1672055
Autor:
Justin T. Breitbach, Hanna Cook, Darian S. Louke, Christopher Premanandan, Joelle M. Fenger, Eric M. Green, Rebecca Makii, Ryan N. Jennings
Publikováno v:
BMC Veterinary Research
BMC Veterinary Research, Vol 16, Iss 1, Pp 1-13 (2020)
BMC Veterinary Research, Vol 16, Iss 1, Pp 1-13 (2020)
Background The WW domain-containing oxidoreductase (WWOX) tumor suppressor gene is frequently lost in a variety of solid and hematopoietic malignancies in humans. Dysregulation of WWOX has been implicated as playing a key role in tumor cell survival,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83f83e1ad785bd51bfe393fca67261d9
https://pubmed.ncbi.nlm.nih.gov/33129329
https://pubmed.ncbi.nlm.nih.gov/33129329
Akademický článek
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Autor:
Amy Lehman, James S. Blachly, Bonnie K. Harrington, Virginia M. Goettl, Katie Williams, Deepa Sampath, Alice S. Mims, Nicole Grieselhuber, Karl N. Kirschner, Shaneice Mitchell, William Senapedis, Rosa Lapalombella, Pu Zhang, Justin T. Breitbach, Shelley Orwick, Yerdanose Asemelash, Shuai Dong, Sally E. Henderson, Karilyn Larkin, John C. Byrd, Matthew Cannon, Vinay K. Puduvalli, Pankaj Sharma, Erkan Baloglu, Tzung Huei Lai, Larry Beaver
Publikováno v:
Blood advances. 3(3)
Treatment options for acute myeloid leukemia (AML) remain extremely limited and associated with significant toxicity. Nicotinamide phosphoribosyltransferase (NAMPT) is involved in the generation of NAD+ and a potential therapeutic target in AML. We e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32b73b26ed9220d79ad66ed536d7c1b3
https://pubmed.ncbi.nlm.nih.gov/30692102
https://pubmed.ncbi.nlm.nih.gov/30692102