Zobrazeno 1 - 10
of 32
pro vyhledávání: '"T. Bradley Willingham"'
Autor:
Prasanna Katti, Alexander S. Hall, Hailey A. Parry, Peter T. Ajayi, Yuho Kim, T. Bradley Willingham, Christopher K. E. Bleck, Han Wen, Brian Glancy
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
How different physical configurations between sarcomeres and mitochondria alter energetic support for contractile function of skeletal muscle is not clear. Here the authors use advanced 3D imaging and analysis techniques to show how space is made for
Externí odkaz:
https://doaj.org/article/a69b5db0208f4fdca63285b1865a5a19
Autor:
Peter T. Ajayi, Prasanna Katti, Yingfan Zhang, T. Bradley Willingham, Ye Sun, Christopher K. E. Bleck, Brian Glancy
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
Recent work has shown that mammalian muscle cells are comprised of multiple branching sarcomeres, though how this connectivity is regulated has remained unknown. Here the authors show three different mechanisms which regulate connectivity of the musc
Externí odkaz:
https://doaj.org/article/06295c6c1e9e449da290aafd391da01e
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
Skeletal muscle cells have long been considered to be made primarily of many individual, parallel myofibrils. Here, the authors show that the striated muscle contractile machinery forms a highly branched, mesh-like myofibrillar matrix connected acros
Externí odkaz:
https://doaj.org/article/519019aa3ec64184a9cc2d564f6dc75a
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Across different cell types and within single cells, mitochondria are heterogeneous in form and function. In skeletal muscle cells, morphologically and functionally distinct subpopulations of mitochondria have been identified, but the mechanisms by w
Externí odkaz:
https://doaj.org/article/03f5f4419c5647d59102f5ba39ec55ba
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
Assessing biological circuit connections in single cells has been intractable due to lack of appropriate tools. Here, Bleck et al. develop a method to assess mitochondrial network connectivity in muscle cells and observe clear differences consistent
Externí odkaz:
https://doaj.org/article/fecf9499a27d4346b4b6ab29516b9f1b
Publikováno v:
Frontiers in Physiology, Vol 11 (2020)
Mitochondria are key determinants of cellular health. However, the functional role of mitochondria varies from cell to cell depending on the relative demands for energy distribution, metabolite biosynthesis, and/or signaling. In order to support the
Externí odkaz:
https://doaj.org/article/d3ee892f3ef24eb6897982c946a9faf4
Publikováno v:
Frontiers in Physiology, Vol 8 (2017)
The ability to sustain submaximal exercise is largely dependent on the oxidative capacity of mitochondria within skeletal muscle, and impairments in oxidative metabolism have been implicated in many neurologic and cardiovascular pathologies. Here we
Externí odkaz:
https://doaj.org/article/bcb64748a3554440ab7c32886e6c18a2
Publikováno v:
Journal of Functional Morphology and Kinesiology, Vol 4, Iss 1, Pp 12-0 (2019)
Lower back pain is a common symptom potentially associated with skeletal muscle dysfunction. The purpose of this study was to evaluate endurance in the lower back muscles of healthy participants using accelerometer-based mechanomyography. Methods: Yo
Externí odkaz:
https://doaj.org/article/88c94ea486df484f94fc2df67914cf2a
Publikováno v:
Archives of Physical Medicine and Rehabilitation. 104:694-706
Impaired mobility is amongst the most debilitating symptoms reported by people with multiple sclerosis (MS). Historically, it has been viewed that walking impairments in people with MS are directly caused by the physical damage to the neurons in the
Autor:
Yingfan Zhang, T. Bradley Willingham, Laura Reyes, Chengyu Liu, Danielle Springer, Audrey Noguchi, Angel M. Aponte, Jeeva Munasinghe, Raul Covian, Brian Glancy
Depletion of transmembrane protein 65 (TMEM65) in a patient with a homozygous point mutation in the TMEM65 gene splice site was reported to result in mitochondrial dysfunction and severe encephalomyopathy(1), indicating the clinical importance of TME
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d00932474052bdc5591e0a48e335f116
https://doi.org/10.1101/2022.08.02.502535
https://doi.org/10.1101/2022.08.02.502535