Signals of positive selection in genomes of palearctic Myotis-bats coexisting with a fungal pathogen

Autor: V. G. Twort, V. N. Laine, K. A. Field, F. Whiting-Fawcett, F. Ito, M. Reiman, T. Bartonicka, M. Fritze, V. A. Ilyukha, V. V. Belkin, E. A. Khizhkin, D. M. Reeder, D. Fukui, T. L. Jiang, T. M. Lilley

Publikováno v: BMC Genomics, Vol 25, Iss 1, Pp 1-16 (2024)

Abstract Disease can act as a driving force in shaping genetic makeup across populations, even species, if the impacts influence a particularly sensitive part of their life cycles. White-nose disease is caused by a fungal pathogen infecting bats duri

Externí odkaz: https://doaj.org/article/a6ee6584b0a64a80a71c9316e0bcdb55

Treg-driven tumour control by PI3Kδ inhibition limits myeloid-derived suppressor cell expansion

Autor: Sarah N. Lauder, Kathryn Smart, Valentina M. T. Bart, Ana Pires, Jake Scott, Stefan Milutinovic, Andrew Godkin, Bart Vanhaesebroeck, Awen Gallimore

Publikováno v: British journal of cancer. 127(9)

Background Recent studies have demonstrated that blocking the PI3Kδ signalling enzyme (by administering a small molecule inhibitor, PI-3065) can potently improve the anti-tumour T-cell response through direct inhibition of Tregs. This treatment also

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::059bdc03a4d494f1644b7af53a666ae6
https://pubmed.ncbi.nlm.nih.gov/35986086

Effective In Vivo Gene Modification in Mouse Tissue-Resident Peritoneal Macrophages by Intraperitoneal Delivery of Lentiviral Vectors

Autor: Robert H. Jenkins, Luke C. Davies, Valentina M T Bart, Philip R. Taylor, Natacha Ipseiz, Magdalena A. Czubala, Paul Brennan

Publikováno v: Molecular Therapy. Methods & Clinical Development
Molecular Therapy: Methods & Clinical Development, Vol 19, Iss, Pp 375-(2020)
Molecular Therapy: Methods & Clinical Development, Vol 16, Iss, Pp 21-31 (2020)

Tissue-resident macrophages exhibit specialized phenotypes dependent on their in vivo physiological niche. Investigation of their function often relies upon complex whole mouse transgenic studies. While some appropriate lineage-associated promoters e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afa1c7df463fc6401b908b4593029b93
http://europepmc.org/articles/PMC6838965

Neutrophilia, lymphopenia and myeloid dysfunction: a living review of the quantitative changes to innate and adaptive immune cells which define COVID-19 pathology

Autor: Tehmina Bharuchq, Bruce MacLachlan, Ceri Fielding, Adrian L Smith, Fadi Issa, Emily Thornton, Raphael Sanches Peres, Calliope A Dendrou, Dorothée L Berthold, Liliana Cifuentes, Alicia Teijeira Crespo, Elizabeth H Mann, Arvind Sami, Anne Chauveau, Dominic S Alonzi, Anís Gammage, Fabian Fischer, Valentina M T Bart, Fangfang Lu, Miriam O'Hanlon, Lynn B Dustin, Pragati Sabberwal, Ewoud B. Compeer, Mariana Borsa, Rowie Borst, Hannah Almuttaqi, David J Ahern, Eleanor J Pring, Emma Jones, Ester Gea-Mallorquí, Kate Liddiard, Dingxi Zhou, Amy Cross, Sara Danielli, Max Quastel, Shayda Maleki-Toyserkani, Owen R Moon, Ruban Rex Peter Durairaj, Vicky Batchelor, Barbora Schonfeldova, Angus K T Wann, Lorenzo Capitani, Petros Ligoxygakis, Sandra Dimonte, Clara Eléonore Pavillet, Lion F K Uhl, Luke C Davies, Kristin Ladell, Stephanie Jean Hanna, Felix Richter, Freya R Shepherd, Sarah Hulin-Curtis, Stephanie Burnell, Amy Susan Codd, Anita Milicic, Quentin Sattentau, Juliane Brun, David Oliver Scourfield, Sophie Reed, Jan Rehwinkel, Ghada Alsaleh, D Oliver Scourfield, Michael Tellier, Reginald James Matthews, Eleanor Pring, Emma Mitchell, Anna Katharina Simon, Joseph D Wilson, Niamh Richmond, Van Dien Nguyen, Sarah N Lauder, Zihan Zhu, Tharini A Selvakumar, Ana Pires, Cariad Shorten, Richard Williams, Erinke van Grinsven, Sarah Galloway, Aljawharah Alrubayyi, Stephanie J. Hanna, Felix Clemens Richter, Julie M Mazet, Dimitra Peppa, Clarissa Coveney, Awen Gallimore, Cornelia Heuberger, Owen Moon, Ruth Jones, Helene Borrmann, Arthur Dyer, Lucy Chapman, Jelena S Bezbradica, Andrew Godkin, Rebecca Bayliss, Amy S. Codd, Anna M Marzeda, Athena Cavounidis, Patrícia R S Rodrigues, Alice J B Robinson, Ewoud Bernardus Compeer

Publikováno v: Oxford Open Immunology

Destabilization of balanced immune cell numbers and frequencies is a common feature of viral infections. This occurs due to, and further enhances, viral immune evasion and survival. Since the discovery of the Severe Acute Respiratory Syndrome coronav

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b44a2a9d86eac6ea736510e7a102f26e
https://doi.org/10.1093/oxfimm/iqab016

The OPTICON A2IM Cookbook: an introduction to additive manufacture for astronomy

Autor: Navarro, Ramón, Geyl, Roland, Atkins, Carolyn, van de Vorst, L. G. T. (Bart), Conley, Andrew, Farkas, Szigfrid, Hugot, Emmanuel, Mező, György, Morris, Katherine, Roulet, Mélanie, Snell, Robert M., Tenegi-Sanginés, Fabio, Todd, Iain, Vega-Moreno, Afrodisio, Schnetler, Hermine

Publikováno v: Proceedings of SPIE; August 2022, Vol. 12188 Issue: 1 p121880W-121880W-17, 12066138p