Zobrazeno 1 - 10
of 11
pro vyhledávání: '"T. B. Tikhonova"'
Autor:
O. I. Barygin, T. B. Tikhonova
Publikováno v:
Neuroscience and Behavioral Physiology. 49:797-803
Proton-activated ion channels (ASICs) are widely distributed in the CNS and take part in many physiological processes. We report here studies characterizing pH-induced currents in various neuron types. Overall, the data provide evidence that currents
Autor:
Anastasiia S. Korosteleva, Denis B. Tikhonov, Maxim V. Nikolaev, Oleg I. Barygin, Margarita S. Komarova, T. B. Tikhonova, Lev G. Magazanik
Publikováno v:
Channels. 11:648-659
Proton-gated channels of the ASIC family are widely distributed in the mammalian brain, and, according to the recent data, participate in synaptic transmission. However, ASIC-mediated currents are small, and special efforts are required to detect the
Autor:
Natalia N. Potapieva, Vasilii Y. Shteinikov, Denis B. Tikhonov, Anastasiia S. Korosteleva, T. B. Tikhonova
Publikováno v:
Biochemical and biophysical research communications. 490(4)
Recently we found that synthetic compounds containing amino group linked to hydrophobic or aromatic moiety are potent modulators of the proton-gated channels (ASICs). These structures have clear similarity with ligands of histamine receptors. We have
Publikováno v:
Neuroscience and Behavioral Physiology. 41:647-653
The ionic composition of the medium can influence the actions of many pharmacological agents. We report here our studies of the effects of the extracellular sodium concentration on blockade of calcium-permeable ion channels of AMPA receptors by the c
Publikováno v:
Journal of Molecular Neuroscience. 39:169-174
Adamantane derivative IEM-1676 (Ad-N(+)H(2)-(CH(2))(5)-N(+)Me(3)) causes open-channel block of Ca(2+)-permeable AMPA receptors when applied externally, but internal application results in both closed- and open-channel block. The relationships between
Autor:
L. V. Gorbunova, T. B. Tikhonova, L. A. Starshinova, Lev G. Magazanik, V. E. Gmiro, V. V. Lavrent’eva, E. P. Zhabko, N. Ya. Lukomskaya
Publikováno v:
Neuroscience and Behavioral Physiology. 37:75-81
Experiments on mice were performed to study the ability of monocationic and dicationic adamantane and phenylcyclohexyl derivatives to prevent the development of kindling induced by i.p. administration of pentylenetetrazol (Corasol, 35 mg/kg). The mon
Publikováno v:
Neuropharmacology. 54(4)
The voltage-dependent block of AMPA receptor (AMPAR) channels by a series of dicationic compounds was studied on native GluR2-lacking receptors of striatal giant interneurons isolated from rat brain slices. The dicationic derivatives of adamantane, d
Publikováno v:
Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova. 92(1)
The mechanism of blocking effect of phenylcyclohexyl derivative, IEM-1925, on ionotropic glutamate receptors of the NMDA and AMPA types has been studied on the rat isolated brain neurons. The whole-cell configuration of patck clanp recording techniqu
Autor:
Y. I. Salnikov, T. B. Tikhonova, Oleg I. Barygin, Denis B. Tikhonov, Lev G. Magazanik, N. A. Dorofeeva
Publikováno v:
Journal of neurochemistry. 95(6)
The effects of divalent cations on Ca2+-impermeable containing (GluR2 subunit) MPA receptors of hippocampal pyramidal neurones isolated from rat brain was studied using patch-clamping. Ca2+, Mg2+, Mn2+, Co2+, Ni2+ and Zn2+ inhibited currents induced
Publikováno v:
Neuroscience and behavioral physiology. 37(3)
The mechanism of the blocking action of phenylcyclohexyl derivative IEM-1925 on ionotropic NMDA and AMPA glutamate receptors was studied. Experiments on isolated rat brain neurons (hippocampal pyramidal cells and striatal cholinergic interneurons) we