Proteins at Interfaces III State of the Art

Autor: Thomas A. Horbett, John L. Brash, Willem Norde, Laura E. Valenti, Elisa Herrera, María Fernanda Stragliotto, Vitor L. Martins, Roberto M. Torresi, Carla E. Giacomelli, Sunita Prem Victor, Chandra P. Sharma, Adrienne Roehrich, Jason Ash, Ariel Zane, David L. Masica, Jeffrey J. Gray, Gil Goobes, Gary Drobny, Zbigniew Adamczyk, Monika Wasilewska, Małgorzata Nattich-Rak, Jakub Barbasz, Javier Sotres, Liselott Lindh, Olof Svensson, Alejandro Barrantes, Thomas Arnebrant, A. Dan, G. Gochev, Cs. Kotsmar, J. K. Ferri, A. Javadi, M. Karbaschi, J. Krägel, R. Wüstneck, R. Miller, Eva Bittrich, Sina Burkert, Klaus-Jochen Eichhorn, Manfred Stamm, Petra Uhlmann, T. Abramyan, G. Collier, T. G. Kucukkal, X. Li, J. A. Snyder, A. A. Thyparambil, N. A. Vellore, Y. Wei, J. A. Yancey, S. J. Stuart, R. A. Latour, L. Bellucci, G. Brancolini, A. Calzolari, O. Carrillo Parramon, S. Corni, R. Di Felice, Jia Luo, Zhi-Kang Xu, Dan Li, Hong Chen, Luisa M. Szott, David W. Baker, Liping Tang, Chun-Ping Xu, Henk J. Busscher, Henny C. van der Mei, Li-Chong Xu, Pranav Soman, Bryan M. Sche

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Discovery of a cryptic pocket in the AI-predicted structure of PPM1D phosphatase explains the binding site and potency of its allosteric inhibitors.

Autor: Meller A; Department of Biochemistry and Molecular Biophysics, Washington University in St. Louis, 660 S Euclid Ave, St. Louis, MO, 63110.; Medical Scientist Training Program, Washington University in St. Louis, 660 S Euclid Ave., St. Louis, MO, 63110., de Oliveira S; Atomwise, Inc., 717 Market Street, Suite 800, San Francisco, California 94103., Davtyan A; Atomwise, Inc., 717 Market Street, Suite 800, San Francisco, California 94103., Abramyan T; Atomwise, Inc., 717 Market Street, Suite 800, San Francisco, California 94103., Bowman GR; Department of Biochemistry and Biophysics, University of Pennsylvania, Philadelphia, PA, 19104., van den Bedem H; Atomwise, Inc., 717 Market Street, Suite 800, San Francisco, California 94103.; Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, San Francisco, California 94158.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2023 Mar 24. Date of Electronic Publication: 2023 Mar 24.