Direct on-swab metabolic profiling of vaginal microbiome host interactions during pregnancy and preterm birth

Autor: Pamela Pruski, Gonçalo D. S. Correia, Holly V. Lewis, Katia Capuccini, Paolo Inglese, Denise Chan, Richard G. Brown, Lindsay Kindinger, Yun S. Lee, Ann Smith, Julian Marchesi, Julie A. K. McDonald, Simon Cameron, Kate Alexander-Hardiman, Anna L. David, Sarah J. Stock, Jane E. Norman, Vasso Terzidou, T. G. Teoh, Lynne Sykes, Phillip R. Bennett, Zoltan Takats, David A. MacIntyre

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)

Here, the authors apply DESI-MS, a sample preparation-free, direct on-swab mass spectrometry analytical tool, to profile the cervicovaginal metabolome of two independent cohorts of pregnant women and, combined with matched metataxonomic and immuno-pr

Externí odkaz: https://doaj.org/article/679b2cee8c274823b08f0652136477bc

Clinical outcomes up-to 10 years of asymptomatic incidental aortic dissections and large aortic aneurysms detected on computer tomography aortography (CTA) prior to transcatheter aortic valve implantation (TAVI)

Autor: J H Tan, T K Teoh, J Fong, A Amirthalingam, K Baig

Publikováno v: European Heart Journal. 42

Background/Introduction Computer tomography aortography (CTA) is performed routinely to aid planning of transcatheter aortic valve implantation (TAVI). Incidental findings are common, and may influence the decision to proceed with TAVI. The safety an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::20dc6a76f00f33f61f6fbf4462cf2257
https://doi.org/10.1093/eurheartj/ehab724.2196

Direct on-swab metabolic profiling of vaginal microbiome host interactions during pregnancy and preterm birth

Autor: L Kindinger, Julie A. K. McDonald, Vasso Terzidou, Phillip R. Bennett, Katia Capuccini, Denise Chan, Holly V. Lewis, Anna L. David, Lynne Sykes, David A. MacIntyre, Zoltan Takats, Jane E. Norman, Paolo Inglese, Sarah J. Stock, Kate Alexander-Hardiman, Yun S. Lee, Julian Marchesi, Richard G. Brown, Pamela Pruski, Simon J S Cameron, T. G. Teoh, Ann Smith, Gonçalo D S Correia

Publikováno v: Pruski, P, dos Santos Correia, G, Lewis, H, Capuccini, K, Inglese, P, Chan, D, Brown, R, Kindinger, L, Lee, Y, Smith, A, Marchesi, J, McDonald, J, Cameron, S, Alexander-Hardiman, K, David, A, Stock, S J E, Norman, J, Terzidou, V, Teoh, TG, Sykes, L, Bennett, P, Takats, Z & MacIntyre, D 2021, ' Direct on-swab metabolic profiling of vaginal microbiome host interactions during pregnancy and preterm birth ', Nature Communications, vol. 12, 5967 . https://doi.org/10.1038/s41467-021-26215-w
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Pruski, P, Correia, G D S, Lewis, H V, Capuccini, K, Inglese, P, Chan, D, Brown, R G, Kindinger, L, Lee, Y S, Smith, A, Marchesi, J, McDonald, J A K, Cameron, S, Alexander-Hardiman, K, David, A L, Stock, S J, Norman, J E, Terzidou, V, Teoh, T G, Sykes, L, Bennett, P R, Takats, Z & MacIntyre, D A 2021, ' Direct on-swab metabolic profiling of vaginal microbiome host interactions during pregnancy and preterm birth ', Nature Communications, vol. 12, no. 1, 5967, pp. 5967 . https://doi.org/10.1038/s41467-021-26215-w
Nature Communications

The pregnancy vaginal microbiome contributes to risk of preterm birth, the primary cause of death in children under 5 years of age. Here we describe direct on-swab metabolic profiling by Desorption Electrospray Ionization Mass Spectrometry (DESI-MS)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24442bae3a4714f17dbbc25b9e14db7c
http://hdl.handle.net/10044/1/92499

Microbial-driven preterm labour involves crosstalk between the innate and adaptive immune response

Autor: Denise, Chan, Phillip R, Bennett, Yun S, Lee, Samit, Kundu, T G, Teoh, Malko, Adan, Saqa, Ahmed, Richard G, Brown, Anna L, David, Holly V, Lewis, Belen, Gimeno-Molina, Jane E, Norman, Sarah J, Stock, Vasso, Terzidou, Pascale, Kropf, Marina, Botto, David A, MacIntyre, Lynne, Sykes

Publikováno v: Nature communications. 13(1)

There has been a surge in studies implicating a role of vaginal microbiota in spontaneous preterm birth (sPTB), but most are associative without mechanistic insight. Here we show a comprehensive approach to understand the causative factors of preterm

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::f9cdf0740e83d066281ce89a3118112c
https://pubmed.ncbi.nlm.nih.gov/35190561

Rapid quality improvement in a preterm birth clinic care pathway during the COVID-19 pandemic

Autor: Holly V. Lewis, T. G. Teoh, Sara Zarasvand, Lynne Sykes, Katherine Mountain, Karen Joash, Erna Bayar, Sabrina Das, Malko Adan, Phillip R. Bennett

Publikováno v: BMJ Open Quality
e001049
BMJ Open Quality, Vol 9, Iss 4 (2020)

BackgroundPreterm birth (PTB) occurs in 8% of births in the UK. At Imperial College Healthcare NHS Trust, our PTB prevention clinic manages the care of approximately 1000 women/year. Women referred to the clinic are seen from 12 weeks of pregnancy wi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87925c27f7455eda13817ef6d8e96f84