Zobrazeno 1 - 10
of 2 248
pro vyhledávání: '"T., Rosen"'
Autor:
Stav Rabani, Emine Gulsen Gunes, Martin Gunes, Bianca Pellegrino, Bar Lampert, Keren David, Raju Pillai, Aimin Li, Shirly Becker-Herman, Steven T. Rosen, Idit Shachar
Publikováno v:
Cell Reports, Vol 43, Iss 11, Pp 114920- (2024)
Summary: Triple-negative breast cancer (TNBC) is the most aggressive breast cancer subtype. The tumor microenvironment (TME) plays a major regulatory role in TNBC progression and is highly infiltrated by suppressive immune cells that reduce anti-tumo
Externí odkaz:
https://doaj.org/article/07986e34a7fa4417aebf0d3aa8f5f5cf
Autor:
Tamer Othman, Paul Frankel, Pamela Allen, Leslie L. Popplewell, Geoffrey Shouse, Tanya Siddiqi, Alexey V. Danilov, Nora Ruel, Shari Daniels, Lacolle Peters, Stella Khoo, Steven T. Rosen, Elad Sharon, Miguel Villalona-Calero, Christopher Ruel, Joseph Tuscano, Alex F. Herrera
Publikováno v:
Haematologica, Vol 999, Iss 1 (2024)
Patients with relapsed/refractory (R/R) transformed diffuse large B-cell lymphoma (DLBCL) from indolent B-cell lymphomas, including Richter transformation (RT), have a poor prognosis. PD-1/PD-L1 antibodies produce modest objective and complete respon
Externí odkaz:
https://doaj.org/article/80f0e87d39424a2e83c6b1d56fb77f40
Autor:
Meilin Xue, Lei Dong, Honghai Zhang, Yangchan Li, Kangqiang Qiu, Zhicong Zhao, Min Gao, Li Han, Anthony K. N. Chan, Wei Li, Keith Leung, Kitty Wang, Sheela Pangeni Pokharel, Ying Qing, Wei Liu, Xueer Wang, Lili Ren, Hongjie Bi, Lu Yang, Chao Shen, Zhenhua Chen, Laleh Melstrom, Hongzhi Li, Nikolai Timchenko, Xiaolan Deng, Wendong Huang, Steven T. Rosen, Jingyan Tian, Lin Xu, Jiajie Diao, Chun-Wei Chen, Jianjun Chen, Baiyong Shen, Hao Chen, Rui Su
Publikováno v:
Journal of Hematology & Oncology, Vol 17, Iss 1, Pp 1-24 (2024)
Abstract Background While liver cancer stem cells (CSCs) play a crucial role in hepatocellular carcinoma (HCC) initiation, progression, recurrence, and treatment resistance, the mechanism underlying liver CSC self-renewal remains elusive. We aim to c
Externí odkaz:
https://doaj.org/article/b8cac747695b48e59f1516ff7bd9a5a7
Autor:
David A. Rower, Leon Ding, Helin Zhang, Max Hays, Junyoung An, Patrick M. Harrington, Ilan T. Rosen, Jeffrey M. Gertler, Thomas M. Hazard, Bethany M. Niedzielski, Mollie E. Schwartz, Simon Gustavsson, Kyle Serniak, Jeffrey A. Grover, William D. Oliver
Publikováno v:
PRX Quantum, Vol 5, Iss 4, p 040342 (2024)
Qubit decoherence unavoidably degrades the fidelity of quantum logic gates. Accordingly, realizing gates that are as fast as possible is a guiding principle for qubit control, necessitating protocols for mitigating error channels that become signific
Externí odkaz:
https://doaj.org/article/112e7ea9e4e64fdebb0fc3ef60517918
Autor:
Tamara Mirzapoiazova, Liz Tseng, Bolot Mambetsariev, Haiqing Li, Chih-Hong Lou, Alex Pozhitkov, Sravani Keerthi Ramisetty, Sangkil Nam, Isa Mambetsariev, Brian Armstrong, Jyoti Malhotra, Leonidas Arvanitis, Mohd Wasim Nasser, Surinder K. Batra, Steven T. Rosen, Deric L. Wheeler, Sharad S. Singhal, Prakash Kulkarni, Ravi Salgia
Publikováno v:
iScience, Vol 27, Iss 6, Pp 110132- (2024)
Summary: Although up to 80% small cell lung cancer (SCLC) patients’ response is good for first-line chemotherapy regimen, most patients develop recurrence of the disease within weeks to months. Here, we report cytostatic effect of leflunomide (Lefl
Externí odkaz:
https://doaj.org/article/c1d2afcf8682490aa1a6bb5963b1e1f1
Publikováno v:
Cell Insight, Vol 3, Iss 2, Pp 100150- (2024)
As the dynamic evolution of SARS-CoV-2 led to reduced efficacy in monoclonal neutralizing antibodies and emergence of immune escape, the role of bispecific antibodies becomes crucial in bolstering antiviral activity and suppressing immune evasion. Th
Externí odkaz:
https://doaj.org/article/b5a4952f5af2440aae968b401023b566
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Recently, cancer immunotherapy has revolutionized cancer treatment. Various forms of immunotherapy have a manageable safety profile and result in prolongation of overall survival in patients with solid tumors, but only in a proportion of patients. Va
Externí odkaz:
https://doaj.org/article/18a1cfa7eccf4906a45de9636f67d9a2
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-14 (2023)
Abstract Energy drinks, often advertised as dietary supplements that enhance physical and mental performance, have gained increasing popularity among adolescents and athletes. Several studies on individual ingredients such as caffeine or taurine have
Externí odkaz:
https://doaj.org/article/51b267c32387429faadbc1ae41d7e379
Autor:
James Godfrey, Matthew Mei, Lu Chen, Joo Y. Song, Victoria Bedell, Elizabeth Budde, Saro Armenian, Sandrine Puverel, Liana Nikolaenko, Robert Chen, Shari Daniels, Neena Kennedy, Lacolle Peters, Steven T. Rosen, Stephen J. Forman, Leslie L. Popplewell, Larry W. Kwak, Alex F. Herrera
Publikováno v:
Haematologica, Vol 109, Iss 2 (2023)
Outcomes after programmed death-1 (PD-1) blockade in B-cell lymphomas are disappointing with few durable responses. Histone deacetylase inhibitors exhibit favorable immunomodulatory effects and demonstrate synergistic anti-tumor immune responses with
Externí odkaz:
https://doaj.org/article/ca13d2b46a794156a04e53d9d477b58f
Autor:
Zhen Han, Xiwei Wu, Hanjun Qin, Yate-Ching Yuan, Daniel Schmolze, Chingyu Su, Jasmine Zain, Lilach Moyal, Emmilia Hodak, James F. Sanchez, Peter P. Lee, Mingye Feng, Steven T. Rosen, Christiane Querfeld
Publikováno v:
JCI Insight, Vol 8, Iss 13 (2023)
Cutaneous T cell lymphoma (CTCL) is a disfiguring and incurable disease characterized by skin-homing malignant T cells surrounded by immune cells that promote CTCL growth through an immunosuppressive tumor microenvironment (TME). Preliminary data fro
Externí odkaz:
https://doaj.org/article/aea90ab340bd4aec9702c4b9ba05a095