Phosphatidylinositol-4,5-Bisphosphate Binding to Amphiphysin-II Modulates T-Tubule Remodeling: Implications for Heart Failure

Autor: Junlan Zhou, Neha Singh, Chloe Monnier, William Marszalec, Li Gao, Jing Jin, Michael Frisk, William E. Louch, Suresh Verma, Prasanna Krishnamurthy, Elsa Nico, Maaz Mulla, Gary L. Aistrup, Raj Kishore, J. Andrew Wasserstrom

Publikováno v: Frontiers in Physiology, Vol 12 (2021)

BIN1 (amphyphysin-II) is a structural protein involved in T-tubule (TT) formation and phosphatidylinositol-4,5-bisphosphate (PIP2) is responsible for localization of BIN1 to sarcolemma. The goal of this study was to determine if PIP2-mediated targeti

Externí odkaz: https://doaj.org/article/6d65aa37066c4ce8a35e0b34b74789aa

T-tubule disruption promotes calcium alternans in failing ventricular myocytes: Mechanistic insights from computational modeling

Autor: James N. Weiss, Zhilin Qu, Michael Nivala, Zhen Song

Publikováno v: Nivala, M; Song, Z; Weiss, JN; & Qu, Z. (2015). T-tubule disruption promotes calcium alternans in failing ventricular myocytes: Mechanistic insights from computational modeling. Journal of Molecular and Cellular Cardiology, 79, 32-41. doi: 10.1016/j.yjmcc.2014.10.018. UCLA: Retrieved from: http://www.escholarship.org/uc/item/6vg6q7xf

© 2014 Elsevier Ltd. In heart failure (HF), T-tubule (TT) disruption contributes to dyssynchronous calcium (Ca) release and impaired contraction, but its role in arrhythmogenesis remains unclear. In this study, we investigate the effects of TT disru

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1c1e101b1097d16a808c772dd6debd5
https://doi.org/10.1016/j.yjmcc.2014.10.018

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