Prolonged Ca²⁺ release refractoriness and T‐tubule disruption as determinants of increased propensity to cardiac alternans in the hypertensive heart disease.

Autor: Mariángelo, Juan Ignacio Elio¹ (AUTHOR), Di Marzio, Gabriel Darío¹ (AUTHOR), Gonano, Luis Alberto¹ (AUTHOR), Said, Matilde¹ (AUTHOR) msaid@med.unlp.edu.ar, Mundiña‐Weilenmann, Cecilia¹ (AUTHOR) cmundweil@med.unlp.edu.ar

Publikováno v: Acta Physiologica. Jun2023, Vol. 238 Issue 2, p1-13. 13p. 7 Graphs.

T-tubule disruption promotes calcium alternans in failing ventricular myocytes: Mechanistic insights from computational modeling

Autor: Nivala, Michael, Song, Zhen, Weiss, James N., Qu, Zhilin

Publikováno v: In Journal of Molecular and Cellular Cardiology February 2015 79:32-41

T-tubule disruption promotes calcium alternans in failing ventricular myocytes: Mechanistic insights from computational modeling

Autor: James N. Weiss, Zhilin Qu, Michael Nivala, Zhen Song

Publikováno v: Nivala, M; Song, Z; Weiss, JN; & Qu, Z. (2015). T-tubule disruption promotes calcium alternans in failing ventricular myocytes: Mechanistic insights from computational modeling. Journal of Molecular and Cellular Cardiology, 79, 32-41. doi: 10.1016/j.yjmcc.2014.10.018. UCLA: Retrieved from: http://www.escholarship.org/uc/item/6vg6q7xf

© 2014 Elsevier Ltd. In heart failure (HF), T-tubule (TT) disruption contributes to dyssynchronous calcium (Ca) release and impaired contraction, but its role in arrhythmogenesis remains unclear. In this study, we investigate the effects of TT disru

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1c1e101b1097d16a808c772dd6debd5
https://doi.org/10.1016/j.yjmcc.2014.10.018

T-tubule disruption is a prominent feature of HFrEF but not HFpEF

Autor: Frisk, Michael, Le, Christopher, Hou, Yufeng, Røe, Åsmund, Dahl, Christen, Shen, Xin, Sjaastad, Ivar, Lunde, Ida, Gullestad, Lars, Tønnessen, Theis, Sejersted, Ole, Jones, Peter, Louch, William

Publikováno v: In Journal of Molecular and Cellular Cardiology March 2020 140 Supplement:26-26

Inhibition of the late sodium current slows t-tubule disruption during the progression of hypertensive heart disease in the rat

Autor: Deepak K. Gupta, Sridharan Rajamani, Neha Singh, John C. Shryock, Gary L. Aistrup, Luiz Belardinelli, Jason Ng, Mahendra Reddy, Matthew J. O'Toole, Amanda F. Nahhas, Lauren Beussink, Nesrine El-Bizri, Sanjiv J. Shah, James E. Kelly, Sol Misener, Thitipong Mongkolrattanothai, J. Andrew Wasserstrom, Nimi Chirayil

Publikováno v: American Journal of Physiology-Heart and Circulatory Physiology. 305:H1068-H1079

The treatment of heart failure (HF) is challenging and morbidity and mortality are high. The goal of this study was to determine if inhibition of the late Na+ current with ranolazine during early hypertensive heart disease might slow or stop disease

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8ea67b317a8d177da42eab87b087f63
https://doi.org/10.1152/ajpheart.00401.2013