Zobrazeno 1 - 10
of 262
pro vyhledávání: '"T-cell suppression"'
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
T lymphocytes that infiltrate the tumor microenvironment (TME) often fail to function as effective anti-cancer agents. Within the TME, cell-to-cell inhibitory interactions play significant roles in dampening their anti-tumor activities. Recent studie
Externí odkaz:
https://doaj.org/article/196d4c4dcb614399ba338e50e5859c38
Autor:
Vivian Changying Jiang, Dapeng Hao, Preetesh Jain, Yijing Li, Qingsong Cai, Yixin Yao, Lei Nie, Yang Liu, Jingling Jin, Wei Wang, Heng-Huan Lee, Yuxuan Che, Enyu Dai, Guangchun Han, Ruiping Wang, Kunal Rai, Andrew Futreal, Christopher Flowers, Linghua Wang, Michael Wang
Publikováno v:
Molecular Cancer, Vol 21, Iss 1, Pp 1-16 (2022)
Abstract Background Chimeric antigen receptor (CAR) T-cell therapy using brexucabtagene autoleucel (BA) induces remission in many patients with mantle cell lymphoma (MCL), and BA is the only CAR T-cell therapy approved by the FDA for MCL. However, de
Externí odkaz:
https://doaj.org/article/aefec36a3cd54b8a9646daef0e07986d
Autor:
Kevin Roe
Publikováno v:
Heliyon, Vol 8, Iss 12, Pp e11371- (2022)
When multiple intracellular pathogens, such as viruses, bacteria, fungi and protozoan parasites, infect the same host cell, they can help each other. A pathogen can substantially help another pathogen by disabling cellular immune defenses, using non-
Externí odkaz:
https://doaj.org/article/b888b9d7c23e484c8abe1c0ac4235482
Autor:
Eva M. Grützner, Ashley Neizert, Renate Stirner, Raffaele Conca, Immanuel Andrä, Lisa Wolff, Matthias Schiemann, Lesca M. Holdt, Christoph Klein, Johannes R. Bogner, Rika Draenert
Publikováno v:
Translational Medicine Communications, Vol 5, Iss 1, Pp 1-11 (2020)
Abstract Background Polymorphonuclear myeloid-derived suppressor cells (PMN-MDSCs) are an immature cell type that inhibits the effector functions of T lymphocytes in chronic HIV infection. A well-known immunological feature of the disease course is t
Externí odkaz:
https://doaj.org/article/a04ac28dd34f401ead6514506dbe7b7d
Publikováno v:
Bioengineering, Vol 9, Iss 4, p 177 (2022)
Mesenchymal stem cells (MSCs) are one of the most extensively studied stem cell types owing to their capacity for differentiation into multiple lineages as well as their ability to secrete regenerative factors and modulate immune functions. However,
Externí odkaz:
https://doaj.org/article/6cd8514fce834b248f75b710b5c3ffce
Akademický článek
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Autor:
Markus Germann, Nadine Zangger, Marc‐Olivier Sauvain, Christine Sempoux, Amber D Bowler, Pratyaksha Wirapati, Lana E Kandalaft, Mauro Delorenzi, Sabine Tejpar, George Coukos, Freddy Radtke
Publikováno v:
EMBO Molecular Medicine, Vol 12, Iss 1, Pp n/a-n/a (2020)
Abstract High T‐cell infiltration in colorectal cancer (CRC) correlates with a favorable disease outcome and immunotherapy response. This, however, is only observed in a small subset of CRC patients. A better understanding of the factors influencin
Externí odkaz:
https://doaj.org/article/a10c915fbd5647d0990b67d5709c792c
Autor:
Vini John, Leigh A. Kotze, Eliana Ribechini, Gerhard Walzl, Nelita Du Plessis, Manfred B. Lutz
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Monocytic myeloid-derived suppressor cells (M-MDSCs) and granulocytic MDSCs (G-MDSCs) have been found to be massively induced in TB patients as well in murine Mtb infection models. However, the interaction of mycobacteria with MDSCs and its role in T
Externí odkaz:
https://doaj.org/article/8f58f45c06bf42298ba25fe69fdd05f6
Autor:
Yu-feng Liu, Kun-hai Zhuang, Bin Chen, Pei-wu Li, Xuan Zhou, Hua Jiang, Li-mei Zhong, Feng-bin Liu
Publikováno v:
Arthritis Research & Therapy, Vol 20, Iss 1, Pp 1-13 (2018)
Abstract Background Ankylosing spondylitis (AS) is a chronic inflammatory rheumatic disease. The dysregulated immune system plays an important role in the pathogenesis of AS. Myeloid-derived suppressor cells (MDSCs) play a key immunoregulatory role i
Externí odkaz:
https://doaj.org/article/7692432aa2bb4f9eb5bb76e3f9c712c6
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
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