Zobrazeno 1 - 10
of 549
pro vyhledávání: '"T-cell signaling"'
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Expressed on the surface of CD8+ T cells, the CD8 co-receptor is a key component of the T cells that contributes to antigen recognition, immune cell maturation, and immune cell signaling. While CD8 is widely recognized as a co-stimulatory molecule fo
Externí odkaz:
https://doaj.org/article/b90a01080bd544ea9ff2c1bcb3f30d63
Akademický článek
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Akademický článek
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Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Externí odkaz:
https://doaj.org/article/01393d7aad064dbf9200894abc226e41
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
IntroductionTo achieve a healthy and functional immune system, a delicate balance exists between the activation of conventional T cells (Tcon cells) and the suppression by regulatory T cells (Treg). The tyrosine phosphatase SHP-1, a negative regulato
Externí odkaz:
https://doaj.org/article/ffc56bb8fb3f40eaa44a5c5fd8f4fc7a
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 11 (2023)
Insights into the effect of the microbiome’s composition on immune cell function have recently been discerned and further characterized. Microbiome dysbiosis can result in functional alterations across immune cells, including those required for inn
Externí odkaz:
https://doaj.org/article/c5d0915fc07346fd8fcb72410d564bb3
Autor:
Kilian Ruminski, Javier Celis-Gutierrez, Nicolas Jarmuzynski, Emilie Maturin, Stephane Audebert, Marie Malissen, Luc Camoin, Guillaume Voisinne, Bernard Malissen, Romain Roncagalli
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
The propagation and diversification of signals downstream of the T cell receptor (TCR) involve several adaptor proteins that control the assembly of multimolecular signaling complexes (signalosomes). The global characterization of changes in protein-
Externí odkaz:
https://doaj.org/article/5e912809456643aba8f129a48c1cf596
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
MALT1 is a core component of the CARD11-BCL10-MALT1 (CBM) signalosome, in which it acts as a scaffold and a protease to bridge T cell receptor (TCR) ligation to immune activation. As a scaffold, MALT1 binds to TRAF6, and T cell-specific TRAF6 ablatio
Externí odkaz:
https://doaj.org/article/8683bb0354b34951a566a912bf384599
Autor:
Khadijeh Alishah, Matthias Birtel, Elham Masoumi, Leila Jafarzadeh, Hamid Reza Mirzaee, Jamshid Hadjati, Ralf-Holger Voss, Mustafa Diken, Sedighe Asad
Publikováno v:
Journal of Translational Medicine, Vol 19, Iss 1, Pp 1-21 (2021)
Abstract Background CAR T-cell therapy has been recently unveiled as one of the most promising cancer therapies in hematological malignancies. However, solid tumors mount a profound line of defense to escape immunosurveillance by CAR T-cells. Among t
Externí odkaz:
https://doaj.org/article/8769556c873e4b6a8c4b997f63fda4a0
Autor:
Bhawna Sharma, Diwakar Rathour, Sumbul Uddin, Beenu Joshi, Devendra Singh Chauhan, Santosh Kumar
Publikováno v:
Frontiers in Medicine, Vol 9 (2022)
IntroductionT cells are crucial for pathogenesis as well as control for tuberculosis (TB). Although much is known about the signaling pathways which are required for the activation of T cells during acute infection but the way these cells respond dur
Externí odkaz:
https://doaj.org/article/5662df2f9c7b46cd9f0effb01727e527