Mitochondrial dynamics and metabolic regulation control T cell fate in the thymus

Autor: Rima Elhage, Mairead Kelly, Nicolas Goudin, Jérôme Megret, Agnès Legrand, Ivan Nemazanyy, Cécilia Patitucci, Véronique Quellec, Timothy Wai, Ahmed Hamaï, Sophie Ezine

Publikováno v: Frontiers in Immunology, Vol 14 (2024)

Several studies demonstrated that mitochondrial dynamics and metabolic pathways control T cell fate in the periphery. However, little is known about their implication in thymocyte development. Our results showed that thymic progenitors (CD3-CD4-CD8-

Externí odkaz: https://doaj.org/article/8179045982c54527bc94f4e88502b947

CD3G or CD3D Knockdown in Mature, but Not Immature, T Lymphocytes Similarly Cripples the Human TCRαβ Complex

Autor: Beatriz Garcillán, Patricia Fuentes, Ana V. Marin, Rebeca F. Megino, Daniel Chacon-Arguedas, Marina S. Mazariegos, Anaïs Jiménez-Reinoso, Miguel Muñoz-Ruiz, Raquel G. Laborda, Paula P. Cárdenas, Edgar Fernández-Malavé, Maria L. Toribio, José R. Regueiro

Publikováno v: Frontiers in Cell and Developmental Biology, Vol 9 (2021)

The human αβ T-cell receptor (TCR) is composed of a variable heterodimer (TCRαβ) and three invariant dimers (CD3γε, CD3δε, and ζζ/CD2472). The role of each invariant chain in the stepwise interactions among TCR chains along the assembly is

Externí odkaz: https://doaj.org/article/f22f1ad542f849088084b9af82e689f6

Myeloid Derived Suppressor Cells Expansion Persists After Early ART and May Affect CD4 T Cell Recovery

Autor: Chiara Agrati, Nicola Tumino, Veronica Bordoni, Carmela Pinnetti, Andrea Sabatini, Alessandra Amendola, Isabella Abbate, Patrizia Lorenzini, Annalisa Mondi, Rita Casetti, Eleonora Cimini, Germana Grassi, Andrea Antinori, Alessandra Sacchi

Publikováno v: Frontiers in Immunology, Vol 10 (2019)

Myeloid-derived suppressor cells (MDSC) are expanded during HIV-1 infection and correlated with disease progression. MDSC expand in the early phase of primary infection depending on TRAIL level. In this study we evaluated the effect of ART on the fre

Externí odkaz: https://doaj.org/article/eb48003e1bad44409d4c48d389ebc88e

Uncovering a new cellular origin for acute myeloid leukemia with lineage plasticity

Autor: Melinda Czeh, Frank Rosenbauer

Publikováno v: Molecular & Cellular Oncology, Vol 4, Iss 2 (2017)

Although acute myeloid leukaemia (AML) is assumed to be driven by transformed haematopoietic stem and progenitor cells, we have described recently a new pathway leading to AML from T-cell progenitors. Furthermore, we could identify a subgroup of huma

Externí odkaz: https://doaj.org/article/1b262700f3fd43d5aa6c4736734b1705

CD3G or CD3D Knockdown in Mature, but Not Immature, T Lymphocytes Similarly Cripples the Human TCRαβ Complex

Autor: Ana V. Marin, Daniel Chacon-Arguedas, Anaïs Jiménez-Reinoso, Miguel Muñoz-Ruiz, Raquel G. Laborda, Paula P. Cárdenas, Edgar Fernández-Malavé, Marina S. Mazariegos, Patricia Fuentes, Rebeca F. Megino, María L. Toribio, Beatriz Garcillán, José R. Regueiro

Publikováno v: E-Prints Complutense. Archivo Institucional de la UCM
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Digital.CSIC. Repositorio Institucional del CSIC
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Frontiers in Cell and Developmental Biology

The human αβ T-cell receptor (TCR) is composed of a variable heterodimer (TCRαβ) and three invariant dimers (CD3γε, CD3δε, and ζζ/CD247). The role of each invariant chain in the stepwise interactions among TCR chains along the assembly is s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::039ac8942d4c94b2150985e8370a1b9b
https://doi.org/10.3389/fcell.2021.608490