Detection of antisense protein (ASP) RNA transcripts in individuals infected with human immunodeficiency virus type 1 (HIV-1)

Autor: Brian T. Foley, A. Mancarella, E. de Crignis, Giampietro Corradin, Tilmann Achsel, Giuseppe Pantaleo, Francesco A. Procopio, Claudia Bagni, Cecilia Graziosi

Publikováno v: Journal of General Virology, 100(5), 863-876. Microbiology Society
The Journal of general virology, vol. 100, no. 5, pp. 863-876

The detection of antisense RNA is hampered by reverse transcription (RT) non-specific priming, due to the ability of RNA secondary structures to prime RT in the absence of specific primers. The detection of antisense RNA by conventional RT-PCR does n

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef64eb2637e0b1c67c64e47128777d4b
https://doi.org/10.1099/jgv.0.001244

Heritability of the HIV-1 reservoir size and decay under long-term suppressive ART

Autor: Laura N Walti, Susana Posada Céspedes, Enos Bernasconi, Pietro Vernazza, Chenjie Wan, Matthieu Perreau, Huldrych F. Günthard, François Blanquart, Nadine Bachmann, Sabine Yerly, Teja Turk, Jacques Fellay, Volker Roth, Thomas Klimkait, Manuel Battegay, Jasmina Bogojeska, Niko Beerenwinkel, Venelin Mitov, Karin J. Metzner, Kathrin Neumann, Matthias Cavassini, Jürg Böni, Alexandra Calmy, Roger D. Kouyos

Publikováno v: Nature Communications
Nature Communications, Nature Publishing Group, 2020, 11 (1), ⟨10.1038/s41467-020-19198-7⟩
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
Nature Communications, Vol. 11, No 1 (2020) P. 5542
Nature communications, vol. 11, no. 1, pp. 5542
Wan, Chenjie; Bachmann, Nadine; Mitov, Venelin; Blanquart, François; Céspedes, Susana Posada; Turk, Teja; Neumann, Kathrin; Beerenwinkel, Niko; Bogojeska, Jasmina; Fellay, Jacques; Roth, Volker; Böni, Jürg; Perreau, Matthieu; Klimkait, Thomas; Yerly, Sabine; Battegay, Manuel; Walti, Laura; Calmy, Alexandra; Vernazza, Pietro; Bernasconi, Enos; ... (2020). Heritability of the HIV-1 reservoir size and decay under long-term suppressive ART. Nature communications, 11(1), p. 5542. Nature Publishing Group 10.1038/s41467-020-19198-7

The HIV-1 reservoir is the major hurdle to curing HIV-1. However, the impact of the viral genome on the HIV-1 reservoir, i.e. its heritability, remains unknown. We investigate the heritability of the HIV-1 reservoir size and its long-term decay by an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b95dcfa260f3545209002c69a89fff3
https://hal.archives-ouvertes.fr/hal-03066281/document

Comparative analysis and generation of a robust HIV-1 DNA quantification assay

Autor: Thomas, Jordan, Ruggiero, Allesandra, Procopio, Fransesco, Pantaleo, Guiseppe, Paxton, A William, Pollakis, Georgios

Publikováno v: Journal of virological methods, vol. 263, pp. 24-31
Journal of virological methods, 263, 24-31. Elsevier
Journal of Virological Methods

HIV-1 infection cannot be cured due to the presence of the latent reservoir (LR). Novel cure or treatment strategies, such as "shock and kill" or therapeutic vaccination, aim to reduce or eradicate the LR. Cure strategies utilise robust DNA quantific

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::fc7510240b4dc40f2a2b1f1b57a69054
http://hdl.handle.net/11562/1043925

CD32+ and PD-1+ Lymph Node CD4 T Cells Support Persistent HIV-1 Transcription in Treated Aviremic Individuals

Autor: Raphael Gottardo, Riddhima Banga, Giuseppe Pantaleo, Matthieu Perreau, Craig Fenwick, Francesco A. Procopio, Agostino Riva, Madeleine Suffiotti, Alessandra Noto, Matthias Cavassini, Jean-Marc Corpataux

Publikováno v: Journal of virology, vol. 92, no. 20

A recent study conducted in blood has proposed CD32 as the marker identifying the "elusive" HIV reservoir. We have investigated the distribution of CD32 + CD4 T cells in blood and lymph nodes (LNs) of HIV-1-uninfected subjects and viremic untreated a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e89cb8cc73687e14c141b9047a8c3409
https://serval.unil.ch/resource/serval:BIB_EFF772664CD3.P001/REF.pdf

Impact of CD4 and CD8 dynamics and viral rebounds on loss of virological control in HIV controllers

Autor: Chereau, Fanny, Madec, Yoann, Sabin, Caroline, Obel, Niels, Ruiz-Mateos, Ezequiel, Chrysos, Georgios, Fidler, Sarah, Lehmann, Clara, Zangerle, Robert, Wittkop, Linda, Reiss, Peter, Hamouda, Osamah, Perez, Vicente Estrada, Leal, Manuel, Mocroft, Amanda, De Olalla, Patricia Garcia, Ammassari, Adriana, Monforte, Antonella D'Arminio, Mussini, Cristina, Segura, Ferran, Castagna, Antonella, Cavassini, Matthias, Grabar, Sophie, Morlat, Philippe, De Wit, Stéphane, Lambotte, Olivier, Meyer, Laurence, Judd, Ali, Touloumi, Giota, Warszawski, Josiane, Dabis, François, Krause, Murielle Mary, Ghosn, Jade, Leport, Catherine, Wit, Ferdinand, Prins, Maria, Bucher, Heiner, Gibb, Diana, Fätkenheuer, Gerd, Del Amo, Julia, Thorne, Claire, Kirk, Ole, Stephan, Christoph, Pérez-Hoyos, Santiago, Bartmeyer, Barbara, Chkhartishvili, Nikoloz, Noguera-Julian, Antoni, Antinori, Andrea, Brockmeyer, Norbert, Prieto, Luis, Conejo, Pablo Rojo, Soriano-Arandes, Antoni, Battegay, Manuel, Kouyos, Roger, Tookey, Pat, Casabona, Jordi, Miró, Jose M., Konopnick, Deborah, Goetghebuer, Tessa, Sönnerborg, Anders, Torti, Carlo, Teira, Ramon, Garrido, Myriam, Haerry, David, Miró, Jose Ma, Costagliola, Dominique, D'Arminio-Monforte, Antonella, Raben, Dorthe, Chêne, Geneviève, Barger, Diana, Schwimmer, Christine, Termote, Monique, Campbell, Maria, Frederiksen, Casper M., Friis-Møller, Nina, Kjaer, Jesper, Brandt, Rikke Salbøl, Berenguer, Juan, Bohlius, Julia, Bouteloup, Vincent, Cozzi-Lepri, Alessandro, Davies, Mary-Anne, Dorrucci, Maria, Dunn, David, Egger, Matthias, Furrer, Hansjakob, Guiguet, Marguerite, Leroy, Valériane, Lodi, Sara, Matheron, Sophie, Monge, Susana, Nakagawa, Fumiyo, Paredes, Roger, Phillips, Andrew, Puoti, Massimo, Rohner, Eliane, Schomaker, Michael, Smit, Colette, Sterne, Jonathan, Thiebaut, Rodolphe, Van Der Valk, Marc

Publikováno v: PLoS One
r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
instname
PLoS ONE, Vol 12, Iss 4, p e0173893 (2017)
PLoS ONE
PLoS ONE, Public Library of Science, 2017, 12 (4), pp.e0173893. ⟨10.1371/journal.pone.0173893⟩
Repositorio Institucional de la Consejería de Sanidad de la Comunidad de Madrid
Consejería de Sanidad de la Comunidad de Madrid
PLoS ONE, 2017, 12 (4), pp.e0173893. ⟨10.1371/journal.pone.0173893⟩
PLoS ONE, 12(4). Public Library of Science
Chereau, F, Madec, Y, Sabin, C, Obel, N, Ruiz-Mateos, E, Chrysos, G, Fidler, S, Lehmann, C, Zangerle, R, Wittkop, L, Reiss, P, Hamouda, O, Estrada Perez, V, Leal, M, Mocroft, A, Garcia De Olalla, P, Ammassari, A, D'Arminio Monforte, A, Mussini, C, Segura, F, Castagna, A, Cavassini, M, Grabar, S, Morlat, P, De Wit, S, Lambotte, O, Meyer, L & HIV Controllers Project Working Group for the Collaboration of Observational HIV Epidemiological Research Europe (COHERE) in EuroCOORD 2017, ' Impact of CD4 and CD8 dynamics and viral rebounds on loss of virological control in HIV controllers ', PloS one, vol. 12, no. 4, e0173893 . https://doi.org/10.1371/journal.pone.0173893
PloS one, vol. 12, no. 4, pp. e0173893
Digital.CSIC. Repositorio Institucional del CSIC

[Objective] HIV controllers (HICs) spontaneously maintain HIV viral replication at low level without antiretroviral therapy (ART), a small number of whom will eventually lose this ability to control HIV viremia. The objective was to identify factors

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::0e5eb48805ed7ad153f7c947095c051b
https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=6515