CD73 inhibits cGAS-STING and cooperates with CD39 to promote pancreatic cancer

Autor: Célia Jacoberger-Foissac, Isabelle Cousineau, Yacine Bareche, David Allard, Pavel Chrobak, Bertrand Allard, Sandra Pommey, Nouredin Messaoudi, Yannic McNicoll, Geneviève Soucy, Secil Koseoglu, Ricard Masia, Andrew C. Lake, Heewon Seo, Christopher B. Eeles, Neha Rohatgi, Simon C. Robson, Simon Turcotte, Benjamin Haibe-Kains, John Stagg

Publikováno v: Cancer Immunol Res

The ectonucleotidases CD39 and CD73 catalyze extracellular ATP to immunosuppressive adenosine, and as such, represent potential cancer targets. We investigated biological impacts of CD39 and CD73 in pancreatic ductal adenocarcinoma (PDAC) by studying

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c0e74f195e222380e757c09392eb7c1
https://europepmc.org/articles/PMC9812927/

The Tabula Sapiens: A multiple-organ, single-cell transcriptomic atlas of humans

Autor: Robert C, Jones, Jim, Karkanias, Mark A, Krasnow, Angela Oliveira, Pisco, Stephen R, Quake, Julia, Salzman, Nir, Yosef, Bryan, Bulthaup, Phillip, Brown, William, Harper, Marisa, Hemenez, Ravikumar, Ponnusamy, Ahmad, Salehi, Bhavani A, Sanagavarapu, Eileen, Spallino, Ksenia A, Aaron, Waldo, Concepcion, James M, Gardner, Burnett, Kelly, Nikole, Neidlinger, Zifa, Wang, Sheela, Crasta, Saroja, Kolluru, Maurizio, Morri, Serena Y, Tan, Kyle J, Travaglini, Chenling, Xu, Marcela, Alcántara-Hernández, Nicole, Almanzar, Jane, Antony, Benjamin, Beyersdorf, Deviana, Burhan, Kruti, Calcuttawala, Matthew M, Carter, Charles K F, Chan, Charles A, Chang, Stephen, Chang, Alex, Colville, Rebecca N, Culver, Ivana, Cvijović, Gaetano, D'Amato, Camille, Ezran, Francisco X, Galdos, Astrid, Gillich, William R, Goodyer, Yan, Hang, Alyssa, Hayashi, Sahar, Houshdaran, Xianxi, Huang, Juan C, Irwin, SoRi, Jang, Julia Vallve, Juanico, Aaron M, Kershner, Soochi, Kim, Bernhard, Kiss, William, Kong, Maya E, Kumar, Angera H, Kuo, Rebecca, Leylek, Baoxiang, Li, Gabriel B, Loeb, Wan-Jin, Lu, Sruthi, Mantri, Maxim, Markovic, Patrick L, McAlpine, Antoine, de Morree, Karim, Mrouj, Shravani, Mukherjee, Tyler, Muser, Patrick, Neuhöfer, Thi D, Nguyen, Kimberly, Perez, Ragini, Phansalkar, Nazan, Puluca, Zhen, Qi, Poorvi, Rao, Hayley, Raquer-McKay, Nicholas, Schaum, Bronwyn, Scott, Bobak, Seddighzadeh, Joe, Segal, Sushmita, Sen, Shaheen, Sikandar, Sean P, Spencer, Lea C, Steffes, Varun R, Subramaniam, Aditi, Swarup, Michael, Swift, Will, Van Treuren, Emily, Trimm, Stefan, Veizades, Sivakamasundari, Vijayakumar, Kim Chi, Vo, Sevahn K, Vorperian, Wanxin, Wang, Hannah N W, Weinstein, Juliane, Winkler, Timothy T H, Wu, Jamie, Xie, Andrea R, Yung, Yue, Zhang, Angela M, Detweiler, Honey, Mekonen, Norma F, Neff, Rene V, Sit, Michelle, Tan, Jia, Yan, Gregory R, Bean, Vivek, Charu, Erna, Forgó, Brock A, Martin, Michael G, Ozawa, Oscar, Silva, Angus, Toland, Venkata N P, Vemuri, Shaked, Afik, Kyle, Awayan, Olga Borisovna, Botvinnik, Ashley, Byrne, Michelle, Chen, Roozbeh, Dehghannasiri, Adam, Gayoso, Alejandro A, Granados, Qiqing, Li, Gita, Mahmoudabadi, Aaron, McGeever, Julia Eve, Olivieri, Madeline, Park, Neha, Ravikumar, Geoff, Stanley, Weilun, Tan, Alexander J, Tarashansky, Rohan, Vanheusden, Peter, Wang, Sheng, Wang, Galen, Xing, Rebecca, Culver, Les, Dethlefsen, Po-Yi, Ho, Shixuan, Liu, Jonathan S, Maltzman, Ross J, Metzger, Koki, Sasagawa, Rahul, Sinha, Hanbing, Song, Bruce, Wang, Steven E, Artandi, Philip A, Beachy, Michael F, Clarke, Linda C, Giudice, Franklin W, Huang, Kerwyn Casey, Huang, Juliana, Idoyaga, Seung K, Kim, Mark, Krasnow, Christin S, Kuo, Patricia, Nguyen, Thomas A, Rando, Kristy, Red-Horse, Jeremy, Reiter, David A, Relman, Justin L, Sonnenburg, Albert, Wu, Sean M, Wu, Tony, Wyss-Coray

Publikováno v: Science
Tabula Sapiens Consortium* 2022, ' The Tabula Sapiens : A multiple-organ, single-cell transcriptomic atlas of humans ', Science (New York, N.Y.), vol. 376, no. 6594, pp. eabl4896 . https://doi.org/10.1126/science.abl4896

INTRODUCTION: Although the genome is often called the blueprint of an organism, it is perhaps more accurate to describe it as a parts list composed of the various genes that may or may not be used in the different cell types of a multicellular organi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f726fc016f86cd4ce8c15a69dce9f6be
https://pubmed.ncbi.nlm.nih.gov/36198687

Transcriptional correlates of malaria in RTS,S/AS01-vaccinated African children: a matched case-control study

Autor: Gemma Moncunill, Jason Carnes, William Chad Young, Lindsay Carpp, Stephen De Rosa, Joseph J Campo, Augusto Nhabomba, Maxmillian Mpina, Chenjerai Jairoce, Greg Finak, Paige Haas, Carl Muriel, Phu Van, Héctor Sanz, Sheetij Dutta, Benjamin Mordmüller, Selidji T Agnandji, Núria Díez-Padrisa, Nana Aba Williams, John J Aponte, Clarissa Valim, Daniel E Neafsey, Claudia Daubenberger, M Juliana McElrath, Carlota Dobaño, Ken Stuart, Raphael Gottardo

Publikováno v: eLife, Vol 11 (2022)
eLife
eLife, vol. 11, pp. e70393

Background:In a phase 3 trial in African infants and children, the RTS,S/AS01 vaccine (GSK) showed moderate efficacy against clinical malaria. We sought to further understand RTS,S/AS01-induced immune responses associated with vaccine protection.Meth

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91f39dda5f2f260731aea5887d8a00c2

SLAMF Receptor Expression Identifies an Immune Signature That Characterizes Systemic Lupus Erythematosus

Autor: Morgane Humbel, Florence Bellanger, Alice Horisberger, Madeleine Suffiotti, Natalia Fluder, Mariko Makhmutova, Amandine Mathias, Renaud Du Pasquier, Craig Fenwick, Camillo Ribi, Denis Comte

Publikováno v: Frontiers in immunology, vol. 13, pp. 843059

Systemic lupus erythematosus (SLE) is a chronic autoimmune disease of unknown etiology, linked to alterations in both the innate and the adaptive immune system. Due to the heterogeneity of the clinical presentation, the diagnosis of SLE remains compl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16db8881fda274b931548534edd97e6c
https://pubmed.ncbi.nlm.nih.gov/35603218

DRD4 methylation as a potential biomarker for physical aggression

Autor: Richard E. Tremblay, Essi Viding, Esther Walton, Frank Vitaro, Sylvana M. Côté, Moshe Szyf, Jean-Baptiste Pingault, Charlotte A.M. Cecil, Henning Tiemeier, Irene Pappa, Nadine Provencal, Eamon McCrory

Publikováno v: Cecil, C A M, Walton, E, Pingault, J-B, Provençal, N, Pappa, I, Vitaro, F, Côté, S, Szyf, M, Tremblay, R E, Tiemeier, H, Viding, E & McCrory, E J 2018, ' DRD4 methylation as a potential biomarker for physical aggression : An epigenome-wide, cross-tissue investigation ', American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, vol. 177, no. 8, pp. 746-764 . https://doi.org/10.1002/ajmg.b.32689
Cecil, C A M, Walton, E, Pingault, J-B, Provençal, N, Pappa, I, Vitaro, F, Côté, S, Szyf, M, Tremblay, R E, Tiemeier, H, Viding, E & McCrory, E J 2018, ' DRD4 methylation as a potential biomarker for physical aggression : An epigenome-wide, cross-tissue investigation ', American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics, vol. 177, no. 8, pp. 746-764 . https://doi.org/10.1002/ajmg.b.32689
American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 177(8), 746-764. Wiley-Liss Inc.
American Journal of Medical Genetics Part B-Neuropsychiatric Genetics, 177(8), 746-764. Wiley-Liss Inc.
Cecil, C A M, Walton, E, Pingault, J-B, Provencal, N, Pappa, I, Vitaro, F, Cote, S, Szyf, M, Tremblay, R E, Tiemeier, H, Viding, E & McCrory, E J 2018, ' DRD4 methylation as a potential biomarker for physical aggression : An epigenome-wide, cross-tissue investigation ', American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics . https://doi.org/10.1002/ajmg.b.32689

Epigenetic processes that regulate gene expression, such as DNA methylation (DNAm), have been linked to individual differences in physical aggression. Yet, it is currently unclear whether: (a) DNAm patterns in humans associate with physical aggressio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::267c918da9218be3629f0d27ddd8de0a
https://doi.org/10.1002/ajmg.b.32689