Zobrazeno 1 - 10
of 40
pro vyhledávání: '"T-Cell/genetics"'
Autor:
Brian Stevenson, Marion Arnaud, Michal Bassani-Sternberg, Vincent Zoete, Florian Huber, Blanca Navarro Rodrigo, Marta A S Perez, Raphael Genolet, Petra Baumgaertner, Chloe Chong, Julien Schmidt, Lana E. Kandalaft, Philippe Guillaume, Sara Bobisse, Alexandre Harari, Johanna Chiffelle, Morgane Magnin, Melita Irving, Daniel E. Speiser, George Coukos, David Gfeller, Tu Nguyen-Ngoc
Publikováno v:
Nature biotechnology, vol. 40, no. 5, pp. 656-660
The identification of patient-specific tumor antigens is complicated by the low frequency of T cells specific for each tumor antigen. Here we describe NeoScreen, a method that enables the sensitive identification of rare tumor (neo)antigens and of co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83e3c6bf7513b7d8f19e6fefcf9aa0e4
https://doi.org/10.1038/s41587-021-01072-6
https://doi.org/10.1038/s41587-021-01072-6
Autor:
Zhihua Wang, Xi Zhang, Chuankai Zhang, Yutao Li, Shu Lu, Sarajo Mohanta, Christian Weber, Andreas Habenicht, Changjun Yin
Publikováno v:
Atherosclerosis Methods and Protocols, 2419, 727-746
Methods in Molecular Biology ISBN: 9781071619230
Methods in Molecular Biology ISBN: 9781071619230
Although various pro- and anti-inflammatory T cell subsets have been observed in murine and human atherosclerosis, principal issues of T cell immunity remain unanswered: Is atherosclerosis progression critically affected by aberrant T cell responses?
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::736b6abce4928d41a2d035ccea752365
https://doi.org/10.1007/978-1-0716-1924-7_44
https://doi.org/10.1007/978-1-0716-1924-7_44
Publikováno v:
eLife, vol. 11, pp. e76339
CD4 + T cells are critical orchestrators of immune responses against a large variety of pathogens, including viruses. While multiple CD4 + T cell subtypes and their key transcriptional regulators have been identified, there is a lack of consistent de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od______1900::f21eb373d16b0e6e998b1058c092cf8c
https://serval.unil.ch/notice/serval:BIB_0B25A9B1D7B9
https://serval.unil.ch/notice/serval:BIB_0B25A9B1D7B9
Autor:
Julie Leca, Franҫois Lemonnier, Cem Meydan, Jonathan Foox, Samah El Ghamrasni, Diana-Laure Mboumba, Gordon S. Duncan, Jerome Fortin, Takashi Sakamoto, Chantal Tobin, Kelsey Hodgson, Jillian Haight, Logan K. Smith, Andrew J. Elia, Daniel Butler, Thorsten Berger, Laurence de Leval, Christopher E. Mason, Ari Melnick, Philippe Gaulard, Tak W. Mak
Publikováno v:
Cancer cell, vol. 41, no. 2, pp. 323-339.e10
Angioimmunoblastic T cell lymphoma (AITL) is a peripheral T cell lymphoma that originates from T follicular helper (Tfh) cells and exhibits a prominent tumor microenvironment (TME). IDH2 and TET2 mutations co-occur frequently in AITL, but their contr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7f98449df684ef4a2b19530d86d35a8
https://doi.org/10.1016/j.ccell.2023.01.003
https://doi.org/10.1016/j.ccell.2023.01.003
Publikováno v:
Frontiers in immunology, vol. 13, pp. 830021
Virus-specific T cells (VSTs) are an attractive cell therapy platform for the delivery of tumor-targeted transgenic receptors. However, manufacturing with conventional methods may require several weeks and intensive handling. Here we evaluated the fe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::e4e5736d2ae61bcf49bd16f09c0f373f
https://pubmed.ncbi.nlm.nih.gov/35572604
https://pubmed.ncbi.nlm.nih.gov/35572604
Autor:
Tyler A. Herek, Alyssa Bouska, Waseem Lone, Sunandini Sharma, Catalina Amador, Tayla B. Heavican, Yuping Li, Qi Wei, Dylan Jochum, Timothy C. Greiner, Lynette Smith, Stefano Pileri, Andrew L. Feldman, Andreas Rosenwald, German Ott, Soon Thye Lim, Choon Kiat Ong, Joo Song, Elaine S. Jaffe, Gang Greg Wang, Louis Staudt, Lisa M. Rimsza, Julie Vose, Francesco d’Amore, Dennis D. Weisenburger, Wing C. Chan, Javeed Iqbal
Publikováno v:
Herek, T A, Bouska, A, Lone, W, Sharma, S, Amador, C, Heavican, T B, Li, Y, Wei, Q, Jochum, D, Greiner, T C, Smith, L, Pileri, S, Feldman, A L, Rosenwald, A, Ott, G, Lim, S T, Ong, C K, Song, J, Jaffe, E S, Wang, G G, Staudt, L, Rimsza, L M, Vose, J, d'Amore, F, Weisenburger, D D, Chan, W C & Iqbal, J 2022, ' DNMT3A mutations define a unique biological and prognostic subgroup associated with cytotoxic T cells in PTCL-NOS ', Blood, vol. 140, no. 11, pp. 1278-1290 . https://doi.org/10.1182/blood.2021015019
Peripheral T-cell lymphomas (PTCLs) are heterogenous T-cell neoplasms often associated with epigenetic dysregulation. We investigated de novo DNA methyltransferase 3A (DNMT3A) mutations in common PTCL entities, including angioimmunoblastic T-cell lym
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc504a754e67b0565e31a32ec002de2a
https://pubmed.ncbi.nlm.nih.gov/35639959
https://pubmed.ncbi.nlm.nih.gov/35639959
Autor:
Kent Riemondy, Anjana Rao, Brian P. O'Connor, S. Harsha Krovi, Laurent Gapin, Adam R. Lefferts, Jay R. Hesselberth, Leonard L. Dragone, Catherine Halluszczak, Philippa Marrack, Jingjing Zhang, Lisa K. Peterson, Kathryn D. Tuttle, Laura Harmacek, James P. Scott-Browne, Romain Bedel
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
Nature Communications
Nature communications, vol. 9, no. 1, pp. 2650
Nature Communications
Nature communications, vol. 9, no. 1, pp. 2650
During development in the thymus, invariant natural killer T (iNKT) cells commit to one of three major functionally different subsets, iNKT1, iNKT2, and iNKT17. Here, we show that T cell antigen receptor (TCR) signal strength governs the development
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f89e4c35d3becfa75c6b45c62a82a633
http://link.springer.com/article/10.1038/s41467-018-05026-6
http://link.springer.com/article/10.1038/s41467-018-05026-6
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 7, Iss 1, Pp 1-17 (2019)
Journal for Immunotherapy of Cancer
Journal for immunotherapy of cancer, vol. 7, no. 1, pp. 284
Journal for Immunotherapy of Cancer
Journal for immunotherapy of cancer, vol. 7, no. 1, pp. 284
Affinity-optimized T cell receptor (TCR)-engineered lymphocytes targeting tumor antigens can mediate potent antitumor responses in cancer patients, but also bear substantial risks for off-target toxicities. Most preclinical studies have focused on T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::224ac72dd3912a3ea58d339d6d2da6f6
https://doi.org/10.1186/s40425-019-0773-z
https://doi.org/10.1186/s40425-019-0773-z
Autor:
Sofie Gielis, Pieter Moris, Wout Bittremieux, Nicolas De Neuter, Benson Ogunjimi, Kris Laukens, Pieter Meysman
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Frontiers in Immunology
Frontiers in immunology
Frontiers in Immunology
Frontiers in immunology
High-throughput T cell receptor (TCR) sequencing allows the characterization of an individual's TCR repertoire and directly queries their immune state. However, it remains a non-trivial task to couple these sequenced TCRs to their antigenic targets.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::984ec02a7c478ddf5a2f71e808062a9a
https://www.frontiersin.org/article/10.3389/fimmu.2019.02820/full
https://www.frontiersin.org/article/10.3389/fimmu.2019.02820/full
Autor:
Florence Bettens, Jean Villard, Marc Ansari, Yves Chalandon, Anne-Claire Mamez, Sylvie Ferrari-Lacraz, Stéphane Buhler, Carole Dantin, Stavroula Masouridi-Levrat
Publikováno v:
Leukemia, Vol. 34, No 5 (2020) pp. 1422-1432
After allogeneic hematopoietic stem cell transplantation (HSCT), immune reconstitution leads to the development of a new T-cell repertoire. Immune reconstitution could be influenced by events such as conditioning, infections, and graft versus host di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5a95206793ea79dda64702ba8b9fb4a
https://pubmed.ncbi.nlm.nih.gov/31772297
https://pubmed.ncbi.nlm.nih.gov/31772297