Zobrazeno 1 - 10
of 283
pro vyhledávání: '"T van Groen"'
Autor:
I Gureviciene, S Ikonen, K Gurevicius, A Sarkaki, T van Groen, R Pussinen, A Ylinen, H Tanila
Publikováno v:
Neurobiology of Disease, Vol 15, Iss 2, Pp 188-195 (2004)
Mice carrying mutated human APPswe and PS1 (A246E) transgenes (A/P mice) show age-dependent memory impairment in hippocampus-dependent tasks. Moreover, the mice show normal learning in the water maze within a day but impairment across days. We record
Externí odkaz:
https://doaj.org/article/f993126055e14834a151c7ec8bdf9c38
Autor:
Aundrea F. Bartley, Elena W Adlaf, Andrew S. Bohannon, Peter J. Detloff, David K. Crossman, T. van Groen, Linda Overstreet-Wadiche, Laura J. McMeekin, Lynn E. Dobrunz, Rita M. Cowell, John J. Hablitz, Stephanie N. Fox, S.M. Boas
Publikováno v:
Neuroscience
The transcriptional coactivator peroxisome proliferator-activated receptor γ coactivator-1α (PGC-1α) is a critical regulator of genes involved in neuronal metabolism, neurotransmission, and morphology. Reduced PGC-1α expression has been implicate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09a2266e981769b1cfc0f5436ca16656
https://doi.org/10.1016/j.neuroscience.2020.03.036
https://doi.org/10.1016/j.neuroscience.2020.03.036
Akademický článek
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Akademický článek
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Publikováno v:
Frontiers in Bioscience, 17, pp. 2024-34
Frontiers in Bioscience, 17, 2024-34
Frontiers in Bioscience, 17, 2024-34
Contains fulltext : 109402.pdf (Publisher’s version ) (Open Access) Cerebrospinal fluid (CSF) amyloid beta42 (Abeta42) concentrations are decreased in patients with Alzheimer disease (AD). Consequently, low Abeta42 is considered a positive biomarke
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd7e04a60e7f35bfa995624b6a1b6e76
https://hdl.handle.net/2066/109402
https://hdl.handle.net/2066/109402
Autor:
S.L. Carroll, Ling Li, Dongfeng Cao, Carol A. Ballinger, Ashwini A. Katre, T. van Groen, L. Wang, I. Kadisha, Rui-Ming Liu
Publikováno v:
Neurobiology of Aging. 32:1079-1089
Accumulation of amyloid beta peptide (Aβ) in the brain is a pathological hallmark of Alzheimer’s disease (AD); the underlying mechanism, however, is not well understood. In this study, we show that expression of plasminogen activator inhibitor 1 (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e0802960ff66d4dee99307cdd9280ed
https://doi.org/10.1016/j.neurobiolaging.2009.06.003
https://doi.org/10.1016/j.neurobiolaging.2009.06.003
Autor:
Arend Heerschap, Y.D. Reijmer, Laus M. Broersen, Katrien M. Brouwer, T. van Groen, Pieter J. Dederen, C.E.E.M. van der Zee, Amanda J. Kiliaan, Carlijn R. Hooijmans, Dieter Lütjohann
Publikováno v:
Neurobiology of Disease, Vol 33, Iss 3, Pp 482-498 (2009)
Neurobiology of Disease, 33, 482-98
Neurobiology of Disease, 33, 3, pp. 482-98
Neurobiology of Disease, 33, 482-98
Neurobiology of Disease, 33, 3, pp. 482-98
Contains fulltext : 79884.pdf (Publisher’s version ) (Closed access) Cholesterol and docosahexenoic acid (DHA) may affect degenerative processes in Alzheimer's Disease (AD) by influencing Abeta metabolism indirectly via the vasculature. We investig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46d628ec32c4a57d476bca3789a1c469
https://hdl.handle.net/2066/79884
https://hdl.handle.net/2066/79884
Publikováno v:
Neuroscience. 155:182-191
The depletion of neuronal calcium binding proteins deprives neurons of the capacity to buffer high levels of intracellular Ca 2+ and this leaves them vulnerable to pathological processes, such as those present in Alzheimer's disease (AD). The aim of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2cdb673ff90a86aca4333dd232e0127
https://doi.org/10.1016/j.neuroscience.2008.05.023
https://doi.org/10.1016/j.neuroscience.2008.05.023
Publikováno v:
Neuroscience. 119:1185-1197
Alzheimer's disease (AD) is the most common form of dementia in the elderly, and the characteristic pathological hallmarks of the disease are neuritic plaques and neurofibrillary tangles. The sequence of events leading to the extracellular deposition
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e30943f29e7aa0390269f97290d6fa80
https://doi.org/10.1016/s0306-4522(03)00215-x
https://doi.org/10.1016/s0306-4522(03)00215-x
Publikováno v:
Neuroscience. 116:511-517
Transgenic mice carrying human APPswe and PS1-A264E transgenes (A/P mice) have elevated levels of the highly fibrillogenic amyloid Abeta(1-42) (Abeta) and develop amyloid plaques around the age of 9 months. Our aim was to find whether the gradual acc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::313303671f5fc435d7fc35158fc7d36b
https://doi.org/10.1016/s0306-4522(02)00714-5
https://doi.org/10.1016/s0306-4522(02)00714-5