Zobrazeno 1 - 10
of 42
pro vyhledávání: '"T cell retargeting"'
Autor:
Lennart Kühl, Annelie K. Schäfer, Sebastian Kraft, Nadine Aschmoneit, Roland E. Kontermann, Oliver Seifert
Publikováno v:
mAbs, Vol 15, Iss 1 (2023)
ABSTRACTBispecific antibodies are molecules with versatile modes of action and applications for therapy. They are commonly developed as T-cell engagers (TCE), which simultaneously target an antigen expressed by tumor cells and CD3 expressed by T-cell
Externí odkaz:
https://doaj.org/article/dedeb020f41f452187e36cd60d89c9b7
Autor:
Adam R. Root, Gurkan Guntas, Madan Katragadda, James R. Apgar, Jatin Narula, Chew Shun Chang, Sara Hanscom, Matthew McKenna, Jason Wade, Caryl Meade, Weijun Ma, Yongjing Guo, Yan Liu, Weili Duan, Claire Hendershot, Amy C. King, Yan Zhang, Eric Sousa, Amy Tam, Susan Benard, Han Yang, Kerry Kelleher, Fang Jin, Nicole Piche-Nicholas, Sinead E. Keating, Fernando Narciandi, Rosemary Lawrence-Henderson, Maya Arai, Wayne R. Stochaj, Kristine Svenson, Lidia Mosyak, Khetemcnee Lam, Christopher Francis, Kimberly Marquette, Liliana Wroblewska, H. Lily Zhu, Alfredo Darmanin Sheehan, Edward R. LaVallie, Aaron M. D’Antona, Alison Betts, Lindsay King, Edward Rosfjord, Orla Cunningham, Laura Lin, Puja Sapra, Lioudmila Tchistiakova, Divya Mathur, Laird Bloom
Publikováno v:
mAbs, Vol 13, Iss 1 (2021)
We report here the discovery and optimization of a novel T cell retargeting anti-GUCY2C x anti-CD3ε bispecific antibody for the treatment of solid tumors. Using a combination of hybridoma, phage display and rational design protein engineering, we ha
Externí odkaz:
https://doaj.org/article/25a52ae4f12b462d933f760c7786789d
Akademický článek
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Autor:
Alessandro Satta, Giulia Grazia, Francesco Caroli, Barbara Frigerio, Massimo Di Nicola, Francesco Raspagliesi, Delia Mezzanzanica, Nadia Zaffaroni, Alessandro Massimo Gianni, Andrea Anichini, Mariangela Figini
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
T-cell-based immunotherapy strategies have profoundly improved the clinical management of several solid tumors and hematological malignancies. A recently developed and promising immunotherapy approach is to redirect polyclonal MHC-unrestricted T lymp
Externí odkaz:
https://doaj.org/article/f64637329ecd4ce3a1e75b4bcc107985
Autor:
Ulrich Wuellner, Kristina Klupsch, Fabian Buller, Isabella Attinger-Toller, Roger Santimaria, Irene Zbinden, Patricia Henne, Dragan Grabulovski, Julian Bertschinger, Simon Brack
Publikováno v:
Antibodies, Vol 4, Iss 4, Pp 426-440 (2015)
CD3 bispecific therapies retargeting T cells to tumors have recently demonstrated striking activity in patients. Several CD3 bispecific antibodies directed against various tumor targets are currently being investigated in the clinic across different
Externí odkaz:
https://doaj.org/article/ace5b95010614b2c9dd9d0be87c5386d
Akademický článek
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Akademický článek
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K zobrazení výsledku je třeba se přihlásit.
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Autor:
Orla Cunningham, Eric Sousa, Susan Benard, Yongjing Guo, C.M. Francis, Puja Sapra, Laura Lin, Lindsay King, Fang Jin, Weijun Ma, Aaron M. D’Antona, Nicole Piche-Nicholas, Sinead E. Keating, Sara Hanscom, Gurkan Guntas, Wayne Stochaj, Khetemcnee Lam, Claire Hendershot, Liliana Wroblewska, H. Lily Zhu, Kimberly Ann Marquette, Kristine Svenson, Divya Mathur, Fernando Narciandi, Yan Liu, Weili Duan, Edward R. Lavallie, Alison Betts, Rosemary Lawrence-Henderson, Chang Chew Shun, Adam Root, Maya Arai, Madan Katragadda, Amy King, Amy Tam, Jatin Narula, Jason Wade, Kerry Kelleher, Lioudmila Tchistiakova, Lidia Mosyak, Alfredo Darmanin Sheehan, Han Yang, Yan Zhang, James R. Apgar, Edward Rosfjord, Laird Bloom, Caryl L. Meade, Matthew McKenna
Publikováno v:
mAbs
article-version (VoR) Version of Record
article-version (VoR) Version of Record
We report here the discovery and optimization of a novel T cell retargeting anti-GUCY2C x anti-CD3ε bispecific antibody for the treatment of solid tumors. Using a combination of hybridoma, phage display and rational design protein engineering, we ha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6c6dd5658cfd24d66b5b31b6d32bf8c
https://pubmed.ncbi.nlm.nih.gov/33459147
https://pubmed.ncbi.nlm.nih.gov/33459147
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.
Autor:
Massimo Di Nicola, Alessandro Satta, Mariangela Figini, Delia Mezzanzanica, Nadia Zaffaroni, Francesco Caroli, Barbara Frigerio, Alessandro Massimo Gianni, Giulia Grazia, Andrea Anichini, Francesco Raspagliesi
Publikováno v:
Frontiers in Immunology
Frontiers in Immunology, Vol 10 (2019)
Frontiers in Immunology, Vol 10 (2019)
T-cell-based immunotherapy strategies have profoundly improved the clinical management of several solid tumors and hematological malignancies. A recently developed and promising immunotherapy approach is to redirect polyclonal MHC-unrestricted T lymp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d793226c0dccf7f0c2b35ef85433b9c
https://pubmed.ncbi.nlm.nih.gov/31708930
https://pubmed.ncbi.nlm.nih.gov/31708930