T-Cell Progenitors As A New Immunotherapy to Bypass Hurdles of Allogeneic Hematopoietic Stem Cell Transplantation

Autor: Pierre Gaudeaux, Ranjita Devi Moirangthem, Aurélie Bauquet, Laura Simons, Akshay Joshi, Marina Cavazzana, Olivier Nègre, Shabi Soheili, Isabelle André

Publikováno v: Frontiers in Immunology, Vol 13 (2022)

Allogeneic hematopoietic stem cell transplantation (HSCT) is the treatment of preference for numerous malignant and non-malignant hemopathies. The outcome of this approach is significantly hampered by not only graft-versus-host disease (GvHD), but al

Externí odkaz: https://doaj.org/article/67eb6efd9fab41a28bcc937331ffecb7

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Myeloid Derived Suppressor Cells Expansion Persists After Early ART and May Affect CD4 T Cell Recovery

Autor: Chiara Agrati, Nicola Tumino, Veronica Bordoni, Carmela Pinnetti, Andrea Sabatini, Alessandra Amendola, Isabella Abbate, Patrizia Lorenzini, Annalisa Mondi, Rita Casetti, Eleonora Cimini, Germana Grassi, Andrea Antinori, Alessandra Sacchi

Publikováno v: Frontiers in Immunology, Vol 10 (2019)

Myeloid-derived suppressor cells (MDSC) are expanded during HIV-1 infection and correlated with disease progression. MDSC expand in the early phase of primary infection depending on TRAIL level. In this study we evaluated the effect of ART on the fre

Externí odkaz: https://doaj.org/article/eb48003e1bad44409d4c48d389ebc88e

Uncovering a new cellular origin for acute myeloid leukemia with lineage plasticity

Autor: Melinda Czeh, Frank Rosenbauer

Publikováno v: Molecular & Cellular Oncology, Vol 4, Iss 2 (2017)

Although acute myeloid leukaemia (AML) is assumed to be driven by transformed haematopoietic stem and progenitor cells, we have described recently a new pathway leading to AML from T-cell progenitors. Furthermore, we could identify a subgroup of huma

Externí odkaz: https://doaj.org/article/1b262700f3fd43d5aa6c4736734b1705

CD3G or CD3D Knockdown in Mature, but Not Immature, T Lymphocytes Similarly Cripples the Human TCRαβ Complex

Autor: Ana V. Marin, Daniel Chacon-Arguedas, Anaïs Jiménez-Reinoso, Miguel Muñoz-Ruiz, Raquel G. Laborda, Paula P. Cárdenas, Edgar Fernández-Malavé, Marina S. Mazariegos, Patricia Fuentes, Rebeca F. Megino, María L. Toribio, Beatriz Garcillán, José R. Regueiro

Publikováno v: E-Prints Complutense. Archivo Institucional de la UCM
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Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Frontiers in Cell and Developmental Biology

The human αβ T-cell receptor (TCR) is composed of a variable heterodimer (TCRαβ) and three invariant dimers (CD3γε, CD3δε, and ζζ/CD247). The role of each invariant chain in the stepwise interactions among TCR chains along the assembly is s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::039ac8942d4c94b2150985e8370a1b9b
https://doi.org/10.3389/fcell.2021.608490