Zobrazeno 1 - 10
of 3 398
pro vyhledávání: '"T cell epitopes"'
Autor:
Yandan Wu, Xiaotao Liu, Yuan Mao, Ruixue Ji, Lingzhi Xia, Zining Zhou, Yan Ding, Pinqing Li, Yu Zhao, Min Peng, Jie Qiu, Chuanlai Shen
Publikováno v:
Journal of Translational Medicine, Vol 22, Iss 1, Pp 1-16 (2024)
Abstract Background The clinical routine test of HBV-specific T cell reactivity is still limited due to the high polymorphisms of human leukocyte antigens (HLA) in patient cohort and the lack of universal detection kit, thus the clinical implication
Externí odkaz:
https://doaj.org/article/0f085beb8b924e588c1a037a3342840e
Publikováno v:
Frontiers in Allergy, Vol 5 (2024)
Antigen uptake and processing of exogenous proteins is critical for adaptive immunity, particularly for T helper cell activation. Proteins undergo distinct proteolytic processing in endolysosomal compartments of antigen-presenting cells. The resultin
Externí odkaz:
https://doaj.org/article/35014088346b420c9c59db301986cad2
Autor:
Harish Babu Kolla, Mansi Dutt, Anuj Kumar, Roopa Hebbandi Nanjunadappa, Tobias Karakach, Karam Pal Singh, David Kelvin, Peter Paul Clement Mertens, Channakeshava Sokke Umeshappa
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
IntroductionBluetongue (BT) poses a significant threat to the livestock industry, affecting various animal species and resulting in substantial economic losses. The existence of numerous BT virus (BTV) serotypes has hindered control efforts, highligh
Externí odkaz:
https://doaj.org/article/f6472b163f8a4991806c0a7ef9cf8ecd
Autor:
Alexandra Sánchez-Martínez, Sofía Giraldo Hoyos, Juan Carlos Alzate-Ángel, Fanny Guzmán, Tanya Roman, Paula A. Velilla, Liliana Acevedo-Sáenz
Publikováno v:
Heliyon, Vol 10, Iss 12, Pp e33143- (2024)
The HLA-B*35 alleles have been associated with a slow or rapid progression of HIV-1 infection. However, the mechanisms related to HIV-1 progression have yet to be entirely understood. Several reports indicate that the binding affinity between the HLA
Externí odkaz:
https://doaj.org/article/5bcf9025881e4b7fb2ff8c9fbb0ee19c
Autor:
Mohammed Ageeli Hakami
Publikováno v:
BMC Chemistry, Vol 18, Iss 1, Pp 1-15 (2024)
Abstract Zika virus is an infectious virus, that belongs to Flaviviridae family, which is transferred to humans through mosquito vectors and severely threatens human health; but, apart from available resources, no effective and secure vaccine is pres
Externí odkaz:
https://doaj.org/article/a23d7314961d4e32af6a0b964a5b16f8
Autor:
Daniel Marrama, William D. Chronister, Luise Westernberg, Randi Vita, Zeynep Koşaloğlu-Yalçın, Alessandro Sette, Morten Nielsen, Jason A. Greenbaum, Bjoern Peters
Publikováno v:
BMC Bioinformatics, Vol 24, Iss 1, Pp 1-14 (2023)
Abstract Background Numerous tools exist for biological sequence comparisons and search. One case of particular interest for immunologists is finding matches for linear peptide T cell epitopes, typically between 8 and 15 residues in length, in a larg
Externí odkaz:
https://doaj.org/article/1b54dfc343104abe9241d35bfc25c6f1
Autor:
Nele Fritsch, Marina Aparicio-Soto, Caterina Curato, Franziska Riedel, Hermann-Josef Thierse, Andreas Luch, Katherina Siewert
Publikováno v:
Toxics, Vol 12, Iss 11, p 802 (2024)
T cell activation is the final key event (KE4) in the adverse outcome pathway (AOP) of skin sensitization. However, validated new approach methodologies (NAMs) for evaluating this step are missing. Accordingly, chemicals that activate an unusually hi
Externí odkaz:
https://doaj.org/article/17351e7e871d4c7ca170bf7d74bccce1
Publikováno v:
Vaccines, Vol 12, Iss 10, p 1181 (2024)
With the development of novel vaccine strategies, T-cell epitope-based vaccines have become promising prophylactic and therapeutic tools against infectious diseases that cannot be controlled via traditional vaccines. T-cell epitope-based vaccines lev
Externí odkaz:
https://doaj.org/article/b93d4792e5f746aeb480104362148dab
Autor:
Iole Macchia, Valentina La Sorsa, Alessandra Ciervo, Irene Ruspantini, Donatella Negri, Martina Borghi, Maria Laura De Angelis, Francesca Luciani, Antonio Martina, Silvia Taglieri, Valentina Durastanti, Maria Concetta Altavista, Francesca Urbani, Fabiola Mancini
Publikováno v:
Biomolecules, Vol 14, Iss 10, p 1217 (2024)
COVID-19 remains a significant threat, particularly to vulnerable populations. The emergence of new variants necessitates the development of treatments and vaccines that induce both humoral and cellular immunity. This study aimed to identify potentia
Externí odkaz:
https://doaj.org/article/d70778cc12cb480894b4c98047553a86
Autor:
Robin E. Walsh, Angela Nix, Chloé Ackaert, Aurélie Mazy, Jana Schockaert, Sofie Pattyn, Laurent Malherbe
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
T-cell dependent antibody responses to biotherapeutics remain a challenge to the optimal clinical application of biotherapeutics because of their capacity to impair drug efficacy and their potential to cause safety issues. To minimize this clinical i
Externí odkaz:
https://doaj.org/article/187dcf06803947fba4abb18ce530283f