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Akademický článek

Class B Scavenger Receptor CD36 as a Potential Therapeutic Target in Inflammation Induced by Danger-Associated Molecular Patterns

Autor: Irina N. Baranova, Alexander V. Bocharov, Tatyana G. Vishnyakova, Zhigang Chen, Yunbo Ke, Anna A. Birukova, Peter S. T. Yuen, Takayuki Tsuji, Robert A. Star, Konstantin G. Birukov, Amy P. Patterson, Thomas L. Eggerman

Publikováno v: Cells, Vol 13, Iss 23, p 1992 (2024)

The class B scavenger receptor CD36 is known to bind and mediate the transport of lipid-related ligands and it functions as a pattern recognition receptor (PRR) for a variety of pathogens, including bacteria and viruses. In this study, we assessed CD

Externí odkaz: https://doaj.org/article/c5d61df72a594006800ef3bb68735081

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Akademický článek

IL-18 deficiency ameliorates the progression from AKI to CKD

Autor: Junjun Luan, Jingqi Fu, Congcong Jiao, Xiangnan Hao, Zixuan Feng, Lingzi Zhu, Yixiao Zhang, Guangyu Zhou, Hongyu Li, Wei Yang, Peter S. T. Yuen, Jeffrey B. Kopp, Jingbo Pi, Hua Zhou

Publikováno v: Cell Death and Disease, Vol 13, Iss 11, Pp 1-13 (2022)

Abstract Inflammation is an important factor in the progression from acute kidney injury (AKI) to chronic kidney disease (CKD). The role of interleukin (IL)-18 in this progression has not been examined. We aimed to clarify whether and how IL-18 limit

Externí odkaz: https://doaj.org/article/0c552b078d2848538d17d130c2ef86bc

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Akademický článek

Signal to Noise Ratio of a Coded Slit Hyperspectral Sensor

Autor: Jonathan Piper, Peter W. T. Yuen, David James

Publikováno v: Signals, Vol 3, Iss 4, Pp 752-764 (2022)

In recent years, a wide range of hyperspectral imaging systems using coded apertures have been proposed. Many implement compressive sensing to achieve faster acquisition of a hyperspectral data cube, but it is also potentially beneficial to use coded

Externí odkaz: https://doaj.org/article/abef773620204863bda61bdd73f9d1ea

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Akademický článek

The effect of continuous intravenous norepinephrine infusion on systemic hemodynamics in a telemetrically-monitored mouse model of sepsis.

Autor: Tetsushi Yamashita, Jonathan M Street, Brianna C Halasa, Yoshitaka Naito, Takayuki Tsuji, Naoko Tsuji, Naoki Hayase, Peter S T Yuen, Robert A Star

Publikováno v: PLoS ONE, Vol 17, Iss 8, p e0271667 (2022)

Sepsis, a life-threatening organ dysfunction, results from dysregulated host responses to infection and still has a high incidence and mortality. Although administration of vasopressors to treat septic shock is standard of care, the benefits are not

Externí odkaz: https://doaj.org/article/b4d40688bd954ab489d12e49c24aa283

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Akademický článek

Targeting mitochondrial oxidative stress with MitoQ reduces NET formation and kidney disease in lupus-prone MRL-lpr mice

Autor: Mariana J Kaplan, Karen A Fortner, Luz P Blanco, Iwona Buskiewicz, Nick Huang, Pamela C Gibson, Deborah L Cook, Hege L Pedersen, Peter S T Yuen, Michael P Murphy, Ralph C Budd, ANDRAS PERL

Publikováno v: Lupus Science and Medicine, Vol 7, Iss 1 (2020)

Objectives Recent investigations in humans and mouse models with lupus have revealed evidence of mitochondrial dysfunction and production of mitochondrial reactive oxygen species (mROS) in T cells and neutrophils. This can provoke numerous cellular c

Externí odkaz: https://doaj.org/article/34912e8cd0d94179b0e3d306329824f7

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Akademický článek

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