Zobrazeno 1 - 10
of 1 767
pro vyhledávání: '"T Wheeler"'
Autor:
Anjali T. Owens, Milind Desai, Matthew T. Wheeler, Anna Rodonski, Samira Merali, Amy J. Sehnert, Sara Saberi
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 13, Iss 17 (2024)
Mavacamten is the first and only cardiac myosin inhibitor approved in 5 continents for the treatment of adults with symptomatic New York Heart Association class II and III obstructive hypertrophic cardiomyopathy. An evidence‐based rationale was use
Externí odkaz:
https://doaj.org/article/a01f4f2d76b64c1f85ec6c340522d7c9
Autor:
Daniel Seung Kim, Emily L. Chu, Emily E. Keamy-Minor, Ishan Dhananjay Paranjpe, Wilson L. Tang, Jack W. O’Sullivan, Yaanik B. Desai, Michael B. Liu, Elise Munsey, Kimberly Hecker, Isabella Cuenco, Beth Kao, Ellen Bacolor, Colleen Bonnett, Andrea Linder, Kathleen Lacar, Nancy Robles, Cindy Lamendola, Allysonne Smith, Joshua W. Knowles, Marco V. Perez, Masataka Kawana, Karim I. Sallam, Chad S. Weldy, Matthew T. Wheeler, Victoria N. Parikh, Heidi Salisbury, Euan A. Ashley, the Stanford Center for Inherited Cardiovascular Disease, Karim I Sallam, Chad S Weldy, Marco Perez, Joshua W Knowles, Jason Tso, Julia Platt, Chloe Reuter, Tia Moscarello, Ryan Murtha, Jennifer Kohler, Hannah Ison, Mitchel Pariani, Anusha Klinder, Priya Nair, Jennifer Marino, Ruchi Patel, Matthew T Wheeler, Euan A Ashley, Victoria N Parikh
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 11 (2024)
Mavacamten is a first-in-class cardiac myosin ATPase inhibitor, approved by the United States Food and Drug Administration for the treatment of hypertrophic cardiomyopathy with obstructive physiology (oHCM). Here, we present the real-world use of mav
Externí odkaz:
https://doaj.org/article/10cfc802d1ec46fb9a4e39b0fd818be9
Autor:
Sandra Donkervoort, Payam Mohassel, Melanie O'Leary, Devon E. Bonner, Taila Hartley, Nicole Acquaye, Astrid Brull, Tahseen Mozaffar, Mario A. Saporta, David A. Dyment, Jacinda B. Sampson, Sander Pajusalu, Christina Austin‐Tse, Kyle Hurth, Julie S. Cohen, Kirsty McWalter, Jodi Warman‐Chardon, Amy Crunk, A. Reghan Foley, Undiagnosed Diseases Network, Andrew L. Mammen, Matthew T. Wheeler, Anne O'Donnell‐Luria, Carsten G. Bönnemann
Publikováno v:
Annals of Clinical and Translational Neurology, Vol 11, Iss 3, Pp 629-640 (2024)
Abstract Objective ACTN2, encoding alpha‐actinin‐2, is essential for cardiac and skeletal muscle sarcomeric function. ACTN2 variants are a known cause of cardiomyopathy without skeletal muscle involvement. Recently, specific dominant monoallelic
Externí odkaz:
https://doaj.org/article/fb0a803a096f45d484f086ba7b3ad84b
Publikováno v:
Frontiers in Marine Science, Vol 11 (2024)
The giant kelp (Macrocystis pyrifera (Linnaeus) C. Agardh 1820) is a habitat-forming brown seaweed in temperate systems with an unexplored potential as a source of seaweed bioproducts. This study used M. pyrifera sporophytes sourced in Tasmania, Aust
Externí odkaz:
https://doaj.org/article/5cc8dab858724b41b798f09d8170df7e
Autor:
Callan Russell, MaryAnn Campion, Megan E. Grove, Kelly Matsuda, Teri E. Klein, Euan Ashley, Hetanshi Naik, Matthew T. Wheeler, Stuart A. Scott
Publikováno v:
Clinical and Translational Science, Vol 17, Iss 3, Pp n/a-n/a (2024)
Abstract Pharmacogenomics has the potential to inform drug dosing and selection, reduce adverse events, and improve medication efficacy; however, provider knowledge of pharmacogenomic testing varies across provider types and specialties. Given that m
Externí odkaz:
https://doaj.org/article/b38a2859a532460eb13ce046c3411157
Autor:
James T. Wheeler
Publikováno v:
European Physical Journal C: Particles and Fields, Vol 83, Iss 7, Pp 1-18 (2023)
Abstract We study sources for torsion in Poincarè gauge theory in any dimension, signature, and spin. We find that symmetric kinetic terms for non-Yang–Mills bosonic fields of arbitrary rank drive torsion. Our detailed discussion of spin-3/2 Rarit
Externí odkaz:
https://doaj.org/article/149b26ab8f954120949a0348c5693f81
Autor:
James T. Wheeler
Publikováno v:
Nuclear Physics B, Vol 998, Iss , Pp 116397- (2024)
We find a large internal symmetry within 4-dimensional Poincarè gauge theory.In the Riemann-Cartan geometry of Poincaré gauge theory the field equation and geodesics are invariant under projective transformation, just as in affine geometry. However
Externí odkaz:
https://doaj.org/article/a6beb60c1f29497ba3592a3f06bc2e11
Autor:
Robert T. Wheeler
Publikováno v:
mBio, Vol 14, Iss 5 (2023)
ABSTRACT The microbial cell wall is an essential cellular organelle commonly targeted by antimicrobials. It is also a battleground of innate immune recognition where microbes can evade immune recognition by masking essential cell wall components. A r
Externí odkaz:
https://doaj.org/article/940eef4006dd4a3a9839414a15a43e59
Autor:
Taibo Li, Nicole Ferraro, Benjamin J. Strober, Francois Aguet, Silva Kasela, Marios Arvanitis, Bohan Ni, Laurens Wiel, Elliot Hershberg, Kristin Ardlie, Dan E. Arking, Rebecca L. Beer, Jennifer Brody, Thomas W. Blackwell, Clary Clish, Stacey Gabriel, Robert Gerszten, Xiuqing Guo, Namrata Gupta, W. Craig Johnson, Tuuli Lappalainen, Henry J. Lin, Yongmei Liu, Deborah A. Nickerson, George Papanicolaou, Jonathan K. Pritchard, Pankaj Qasba, Ali Shojaie, Josh Smith, Nona Sotoodehnia, Kent D. Taylor, Russell P. Tracy, David Van Den Berg, Matthew T. Wheeler, Stephen S. Rich, Jerome I. Rotter, Alexis Battle, Stephen B. Montgomery
Publikováno v:
Cell Genomics, Vol 3, Iss 10, Pp 100401- (2023)
Summary: Each human genome has tens of thousands of rare genetic variants; however, identifying impactful rare variants remains a major challenge. We demonstrate how use of personal multi-omics can enable identification of impactful rare variants by
Externí odkaz:
https://doaj.org/article/d2548cee9ef64b4fa282cb83949a4d84
Autor:
Nicolas Millet, Norma V. Solis, Diane Aguilar, Michail S. Lionakis, Robert T. Wheeler, Nicholas Jendzjowsky, Marc Swidergall
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-19 (2022)
The beta-glucan receptor EphA2 is known to maintain mucosal immunity. Here, its role in modulating renal immunopathology via IL-23 signalling and ferroptotic cell death during candidiasis is characterised.
Externí odkaz:
https://doaj.org/article/3c028bd6be6b46a8bd56f8bf34764709