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Inhibitors of choline uptake and metabolism cause developmental abnormalities in neurulating mouse embryos

Autor: Melanie C. Fisher, Steven H. Zeisel, Mei-Heng Mar, T. W. Sadler

Publikováno v: Teratology. 64:114-122

Background Choline is an essential nutrient in methylation, acetylcholine and phospholipid biosynthesis, and in cell signaling. The demand by an embryo or fetus for choline may place a pregnant woman and, subsequently, the developing conceptus at ris

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76c131dca4fc2625261aa9bf1e59cea2
https://doi.org/10.1002/tera.1053

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Susceptible periods during embryogenesis of the heart and endocrine glands

Autor: T W Sadler

Publikováno v: Environmental Health Perspectives

One of the original principles of teratology states that, "Susceptibility to teratogenesis varies with the developmental stage at the time of exposure to an adverse influence" [Wilson JG. Environment and Birth Defects. New York:Academic Press, 1973].

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::394862a354a7621aa06daeaf6b4967d1
https://doi.org/10.1289/ehp.00108s3555

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Mechanisms of neural tube closure and defects

Autor: T. W. Sadler

Publikováno v: Mental Retardation and Developmental Disabilities Research Reviews. 4:247-253

Neural tube closure (neurulation) is a complex process involving many cell phenomena. Both extrinsic and intrinsic forces are essential to elevate the neural plate into the neural folds and to bring the folds into apposition for closure. Extrinsic fo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::15d77e8a0aabd6a85741e911cc3a2bba
https://doi.org/10.1002/(sici)1098-2779(1998)4:4<247::aid-mrdd3>3.0.co

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Growth and differentiation factors

Autor: Patricia F. Maness, T. W. Sadler, Jean M. Lauder, Harold C. Slavkin, Phil Mirkes, Kathy Sulik, Elwood Linney, Melissa B. Rogers

Publikováno v: Reproductive Toxicology. 11:331-337

The work group identified a number of research areas where they felt there were significant data gaps where additional research was critical to better understanding of the origins of birth defects and to developing ways for their prevention. These in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b6562582a3c529f7efa9f3dac0127bca
https://doi.org/10.1016/s0890-6238(96)00216-x

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Mouse embryonic cardiac metabolism under euglycemic and hypoglycemic conditions

Autor: T. W. Sadler, Jennifer H. Peet

Publikováno v: Teratology. 54:20-26

Children of mothers with insulin-dependent diabetic mothers (IDDM) have a 2–4 times higher incidence of congenital birth defects as compared to the general population, including cardiac abnormalities, of unknown etiology. Using rodent embryos to ex

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::accfab17e16f5ce33a0d8fdaaee44669
https://doi.org/10.1002/(sici)1096-9926(199607)54:1<20::aid-tera3>3.0.co

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Antisense inhibition ofEngrailed genes in mouse embryos reveals roles for these genes in craniofacial and neural tube development

Autor: Edison T. Liu, Karen A. Augustine, T. W. Sadler

Publikováno v: Teratology. 51:300-310

The roles ofengrailed-1 (En-1) andengrailed-2 (En-2) have been investigated during gastrulation and neurulation in mouse embryos. Using antisense oligonucleotides and murine whole embryo culture, early somite embryos were injected with antisense phos

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25637134d550ade2f9aa75254d37a1ee
https://doi.org/10.1002/tera.1420510506

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Effects of short-term exposure to ethanol on mouse embryos in vitro

Autor: T. W. Sadler, J.A. Tugman, Kathleen K. Sulik, E.S. Hunter

Publikováno v: Toxicology in Vitro. 8:413-421

The adverse developmental effects of ethanol consumption have been documented in humans and in animal models. In animal models, the organ system affected by ethanol administration is dependent on the point in gestation at which the xenobiotic is admi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a076f12d1907082830a6aab3eda930d
https://doi.org/10.1016/0887-2333(94)90163-5

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Diabetic teratogenesis. In vitro evidence for a multifactorial etiology with little contribution from glucose per se

Autor: T. A. Buchanan, K. M. Denno, G. F. Sipos, T. W. Sadler

Publikováno v: Diabetes. 43:656-660

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::450696f546812b4754857a6dd0d0bc9d
https://doi.org/10.2337/diabetes.43.5.656

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Perturbations in choline metabolism cause neural tube defects in mouse embryosin vitro

Autor: Steven H. Zeisel, Mei Heng Mar, T. W. Sadler, Melanie C. Fisher

Publikováno v: The FASEB Journal. 16:619-621

A role for choline during early stages of mammalian embryogenesis has not been established, although recent studies show that inhibitors of choline uptake and metabolism, 2-dimethylaminoethanol (DMAE), and 1-O-octadecyl-2-O-methyl-rac-glycero-3-phosp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8448a36aca4a4f1541238074f784e73
https://doi.org/10.1096/fj.01-0564fje

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