Zobrazeno 1 - 10
of 67
pro vyhledávání: '"T W LeBien"'
Publikováno v:
The Journal of Immunology. 159:5502-5508
The B cell-specific cell surface molecule CD19 is expressed at all stages of B cell development, including normal plasma cells, and mediates signal transduction via interaction with cytoplasmic effector proteins. Cross-linking CD19 on early human B l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4ec29f50a7947d53afd56bfc9aa3cfc3
https://doi.org/10.4049/jimmunol.159.11.5502
https://doi.org/10.4049/jimmunol.159.11.5502
Autor:
B N, Dittel, T W, LeBien
Publikováno v:
Blood. 86:2833-2841
A common sequela to allogeneic or autologous bone marrow transplantation (BMT) is a delay in the reconstitution of a functional B-cell immune response. Therefore, we examined whether the posttransplant BM microenvironment is deficient in supporting t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2901c9ac93077f250359b0b1674ac4db
https://doi.org/10.1182/blood.v86.7.2833.bloodjournal8672833
https://doi.org/10.1182/blood.v86.7.2833.bloodjournal8672833
Autor:
L J Jarvis, T W LeBien
Publikováno v:
The Journal of Immunology. 155:2359-2368
The interaction of normal human B cell precursors with the bone marrow (BM) stromal cells that support their growth and maturation is mediated by adhesion of B cell CD49d/CD29 (alpha 4 beta 1 integrin or VLA-4) to stromal cell signal transduction, we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4424ae66c1815fbd139fadc92c33e312
https://doi.org/10.4049/jimmunol.155.5.2359
https://doi.org/10.4049/jimmunol.155.5.2359
Autor:
B N Dittel, T W LeBien
Publikováno v:
The Journal of Immunology. 154:58-67
The growth of human B cell precursors can be supported by bone marrow (BM) stromal cells and IL-7, but the identity of the responding population is unknown. In the current study, we examined the growth characteristics of FACS-purified CD10+/CD34+/cyt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::32b731f436c1c79d75a41f1a4171741e
https://doi.org/10.4049/jimmunol.154.1.58
https://doi.org/10.4049/jimmunol.154.1.58
Autor:
A W Larson, T W LeBien
Publikováno v:
The Journal of Immunology. 153:584-594
The function of the cell surface molecule CD40 on B cell precursors (BCP) is not well understood. We now report studies using the L cell/CD40 system (anti-CD40 mAb immobilized on CD32+ mouse L cells) to assess the potential function of CD40 during hu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::aa33af4d62b0f8951bc117d3afcf0796
https://doi.org/10.4049/jimmunol.153.2.584
https://doi.org/10.4049/jimmunol.153.2.584
Publikováno v:
Blood. 81:2272-2282
Self-renewal and differentiation of B-cell precursors is dependent on interactions with bone marrow (BM) stromal cells and associated extracellular matrix. We have recently developed an interleukin (IL)-7- dependent, BM-derived stromal cell culture t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::238af7f757ba4eab0b66b51c73c1d6fd
https://doi.org/10.1182/blood.v81.9.2272.bloodjournal8192272
https://doi.org/10.1182/blood.v81.9.2272.bloodjournal8192272
Publikováno v:
Blood. 78:703-710
Interleukin-4 (IL-4) regulates multiple stages of the antigen-dependent phase of B-cell development. However, its precise role in regulating B lymphopoiesis in bone marrow is not as well defined. We examined whether surface IgM- normal and leukemic h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35842793d1b9e29b9f197eca6a30779d
https://doi.org/10.1182/blood.v78.3.703.bloodjournal783703
https://doi.org/10.1182/blood.v78.3.703.bloodjournal783703
Publikováno v:
Blood. 76:1196-1200
Fetal bone marrow B lineage cells representing multiple stages of B cell development were isolated by two-color cell sorting and analyzed for immunoglobulin H and T-cell receptor (TCR) gamma and delta gene rearrangements. Analysis of CD10+/surface mu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc1dba30490f662450297038f2c1c26f
https://doi.org/10.1182/blood.v76.6.1196.bloodjournal7661196
https://doi.org/10.1182/blood.v76.6.1196.bloodjournal7661196
Publikováno v:
Immunological reviews. 175
Mammalian B-cell development can be viewed as a developmental performance with several acts. The acts are represented by checkpoints centered around commitment to the B-lineage and functional Ig gene rearrangement--culminating in expression of the pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f41ef2e695d476f67c959f1885664a76
https://pubmed.ncbi.nlm.nih.gov/10933602
https://pubmed.ncbi.nlm.nih.gov/10933602
Autor:
T W, LeBien
Publikováno v:
Blood. 96(1)
Development of mammalian B-lineage cells is characterized by progression through a series of checkpoints defined primarily by rearrangement and expression of immunoglobulin genes. Progression through these checkpoints is also influenced by stromal ce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a6b86ad28b785b98614caceee727bb1e
https://pubmed.ncbi.nlm.nih.gov/10891425
https://pubmed.ncbi.nlm.nih.gov/10891425