Identification and function probing of an antithrombin IIIβ conformation‐specific antibody

Autor: Chandra Patel, Frank Dittmer, T W Hermiston, Dorian Schönfeld, Subramanian Yegneswaran, P. Bringmann, J. E. Murphy, J.-M. Gu, Michael Strerath, P. Paz, Ye Jin, Uwe Gritzan, Katalin Kauser, T. Myles

Publikováno v: Journal of Thrombosis and Haemostasis. 14:356-365

UNLABELLED ESSENTIALS: Antithrombin III (AT)β binds heparin with higher affinity than ATα. A conformation-specific antibody against ATβ, TPP2009, was made to investigate ATβ in hemostasis. TPP2009 bound specifically to heparin-ATβ and greatly re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a19496ed263a439564bb7ba4a7f8d0d9
https://doi.org/10.1111/jth.13198

The effect of hypoxia on the uptake, replication and lytic potential of group B adenovirus type 3 (Ad3) and type 11p (Ad11p)

Autor: T W Hermiston, M Bauzon, B H Shen

Publikováno v: Gene Therapy. 13:986-990

Replicating, tumor selective viruses are being tested as potential treatments for human cancers. Hypoxia is a pathophysiological cancer condition that alters the lytic potential of the replication-competent adenovirus serotype 5 (Ad5) virus by a mech

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d2e0f7bb75c19b7de6bf0a727b92128
https://doi.org/10.1038/sj.gt.3302736

Global substrate profiling of proteases in human neutrophil extracellular traps reveals consensus motif predominantly contributed by elastase

Autor: T W Hermiston, Dieter E. Jenne, J. E. Murphy, Natascha C. Perera, Ye Jin, Charles S. Craik, Giselle M. Knudsen, Anthony J. O’Donoghue

Publikováno v: PloS one, vol 8, iss 9
PLoS One
PLoS ONE
PLoS ONE, Vol 8, Iss 9, p e75141 (2013)
O'Donoghue, AJ; Jin, Y; Knudsen, GM; Perera, NC; Jenne, DE; Murphy, JE; et al.(2013). Global Substrate Profiling of Proteases in Human Neutrophil Extracellular Traps Reveals Consensus Motif Predominantly Contributed by Elastase. PLoS ONE, 8(9). doi: 10.1371/journal.pone.0075141. UCSF: Retrieved from: http://www.escholarship.org/uc/item/8jw4j476

Neutrophil extracellular traps (NETs) consist of antimicrobial molecules embedded in a web of extracellular DNA. Formation of NETs is considered to be a defense mechanism utilized by neutrophils to ensnare and kill invading pathogens, and has been re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0cd9979c35a1a53f34a2b82015771ad
https://escholarship.org/uc/item/8jw4j476

A cis-acting element in the major immediate-early (IE) promoter of human cytomegalovirus is required for negative regulation by IE2

Autor: T W Hermiston, Bo Liu, Mark F. Stinski

Publikováno v: Journal of Virology. 65:897-903

The major immediate-early promoter (MIEP) of human cytomegalovirus (CMV) contains a number of different enhancer elements in both repetitive and nonrepetitive sequences that influence the level of downstream transcription. This report describes a cis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3c8e231d2d460a27ed558342016123f
https://doi.org/10.1128/jvi.65.2.897-903.1991

Regulated expression of the interferon-beta gene in mice

Autor: Gabor M. Rubanyi, Richard N. Harkins, H S Qian, T W Hermiston, Harald Petry, P Wang, Peter J. Kretschmer, A Orme, C Schaefer, P Szymanski, A Brooks

Publikováno v: Gene therapy. 15(1)

A single plasmid regulated expression vector based upon a mifepristone-inducible two plasmid system, termed pBRES, has been constructed and tested in mice using murine interferon-b (mIFNb) as the transgene. The expression of mIFNb in the circulation

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1055ba9f10b29aa4c1eb050f304b4380
https://pubmed.ncbi.nlm.nih.gov/17637794