Zobrazeno 1 - 10
of 26
pro vyhledávání: '"T W, Von Geldern"'
Autor:
B. K. Sorensen, Kennan C. Marsh, Eugene I. Novosad, T. J. Opgenorth, T. W. Von Geldern, Jinshyun R. Wu-Wong, William J. Chiou, Douglas B. Dixon, Jae Hwan-Soo, A. S. Tasker, Kester Jeffrey A, Steven A. Boyd, M. Winn, Lisa M. Hernández, Robert A. Mantei, Radhika Bal
Publikováno v:
Journal of Medicinal Chemistry. 39:1039-1048
We have discovered a novel class of endothelin (ET) receptor antagonists through pharmacophore analysis of the existing non-peptide ET antagonists. On the basis of this analysis, we determined that a pyrrolidine ring might replace the indian ring in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05c21de90706af0ac034ce4ad4217e0c
https://doi.org/10.1021/jm9505369
https://doi.org/10.1021/jm9505369
Autor:
Kester Jeffrey A, Douglas B. Dixon, Jinshyun R. Wu-Wong, William J. Chiou, Radhika Bal, T. J. Opgenorth, T. W. Von Geldern
Publikováno v:
Journal of Medicinal Chemistry. 39:968-981
Structure-activity studies have been performed in an attempt to improve the potency of a novel series of azole-based endothelin-A (ET A ) selective antagonists. Modifications of the hydrophobic group on the terminal urea produced substantial effects
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5a74069aa426750f7fa109d2b3b49e16
https://doi.org/10.1021/jm950592+
https://doi.org/10.1021/jm950592+
Autor:
Samuel V. Calzadilla, Douglas B. Dixon, Daniel J. Hoffman, Brian D. Dayton, Hugh N. Nellans, Lisa E. Hernandez, William J. Chiou, Jinshyun R. Wu-Wong, Kennan C. Marsh, Kester Jeffrey A, T. J. Opgenorth, T. W. Von Geldern
Publikováno v:
Journal of Medicinal Chemistry. 39:982-991
The oral absorption profile of a family of azole-based ET(A)-selective antagonists has been improved through a rational series of structural modifications which were suggested by analysis of the physicochemical parameter delta log P. Comparison of ur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63fafcb821dd25a65d8813bb585b940a
https://doi.org/10.1021/jm9505932
https://doi.org/10.1021/jm9505932
Autor:
Gerard M. Sullivan, C. A. Marselle, T. W. von Geldern, Jinshyun R. Wu-Wong, Kazumi Shiosaki, A. S. Tasker, T. J. Opgenorth, B. K. Sorensen
Publikováno v:
Journal of Medicinal Chemistry. 36:468-478
Two structurally distinct series of potent and selective inhibitors of an aspartyl protease-like endothelin converting enzyme (ECE) activity identified in the rat lung have been developed. Pepstatin A, which potently inhibits the rat lung ECE, served
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::085eba078fb49fea8a58f54c23e524be
https://doi.org/10.1021/jm00056a007
https://doi.org/10.1021/jm00056a007
Autor:
Radhika Bal, T. J. Opgenorth, T. W. Von Geldern, William J. Chiou, Kester Jeffrey A, Jinshyun R. Wu-Wong, Douglas B. Dixon
Publikováno v:
ChemInform. 27
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9a49826eb60ee0e3041abd7907debb37
https://doi.org/10.1002/chin.199623224
https://doi.org/10.1002/chin.199623224
Autor:
T. J. Opgenorth, T. W. Von Geldern, H.-S. Jae, Kennan C. Marsh, Steven A. Boyd, Jinshyun R. Wu-Wong, Eugene I. Novosad, B. K. Sorensen, William J. Chiou, Lisa M. Hernández, M. Winn, Douglas B. Dixon, Robert A. Mantei, Kester Jeffrey A, A. S. Tasker, Radhika Bal
Publikováno v:
ChemInform. 27
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a9ee79cb15e11b4e4c8f929aa42454f8
https://doi.org/10.1002/chin.199627143
https://doi.org/10.1002/chin.199627143
Autor:
Douglas B. Dixon, Kester Jeffrey A, T. J. Opgenorth, T. W. Von Geldern, C. Hutchins, Jinshyun R. Wu-Wong, William J. Chiou
Publikováno v:
ChemInform. 27
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7684c38aa4e0a1fc68135ddc81e573ad
https://doi.org/10.1002/chin.199623223
https://doi.org/10.1002/chin.199623223
Autor:
T. J. Opgenorth, T. W. Von Geldern, N. S. Kozmina, Bach Nguyen, M. Winn, Gang Liu, Doug Dixon, Kennan C. Marsh, William J. Chiou
Publikováno v:
Journal of medicinal chemistry. 42(18)
The endothelin (ET)-B receptor subtype is expressed on vascular endothelial and smooth muscle cells and mediates both vasodilation and vasoconstriction. On the basis of the pharmacophore of the previously reported ET(A)-specific antagonist 1, (ABT-62
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4fff7bd4480adf301f6590ed9867ba95
https://pubmed.ncbi.nlm.nih.gov/10479299
https://pubmed.ncbi.nlm.nih.gov/10479299
Autor:
T. J. Opgenorth, T. W. Von Geldern, Doug Dixon, M. Winn, H.-S. Jae, Kennan C. Marsh, Bach Nguyen
Publikováno v:
Journal of medicinal chemistry. 40(20)
When the N,N-dialkylacetamide side chain of the highly ETA-selective endothelin antagonist ABT-627 (1; [2R,3R,4S]-2-(4-methoxyphenyl)-4-(1,3-benzodioxol-5-yl)-1-[[N, N-dibutylamino)-carboxyl]methyl]pyrrolidine-3-carboxylic acid; A-147627) is replaced
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c47b1f8df5bc6618b40c7c814ed3fdad
https://pubmed.ncbi.nlm.nih.gov/9379441
https://pubmed.ncbi.nlm.nih.gov/9379441
Publikováno v:
Journal of medicinal chemistry. 39(4)
Structure-activity studies have been performed in an attempt to improve the potency of a novel series of azole-based endothelin-A (ET(A)) selective antagonists. Modifications of the hydrophobic group on the terminal urea produced substantial effects
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::7e10fdac3ccfad80b9a426c5605c9451
https://pubmed.ncbi.nlm.nih.gov/8632420
https://pubmed.ncbi.nlm.nih.gov/8632420