Zobrazeno 1 - 10
of 24
pro vyhledávání: '"T W, Loo"'
Autor:
Wilbert H. H. Ho, Daniel Y. Z. Lim, Nishanth Thiagarajan, Hankun Wang, Wesley T. W. Loo, Gerald G. R. Sng, Joshua S. W. Lee, Xiayan Shen, Mayank Dalakoti, Ching‐Hui Sia, Benjamin Y. Q. Tan, Huai Yang Lim, Luo‐Kai Wang, Weien Chow, Terrance S. J. Chua, Paul C. Y. Lim, Tee Joo Yeo, Daniel T. T. Chong
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 12, Iss 7 (2023)
BACKGROUND Electrocardiography (ECG) may be performed as part of preparticipation sports screening. Recommendations on screening of athletes to identify individuals with previously unrecognized cardiac disease are robust; however, data guiding the pr
Externí odkaz:
https://doaj.org/article/b6a524a7560a4150b82c63e01f1a01be
Publikováno v:
The Journal of Physiology. 486:707-714
1. P-glycoprotein, the protein product of the multidrug resistance (MDR1) gene, has ATP-dependent transporter activity. It has been suggested that P-glycoprotein may also function as a volume-regulated chloride channel or chloride channel regulator.
Autor:
T W, Loo, D M, Clarke
Publikováno v:
The Journal of biological chemistry. 276(34)
We identified a thiol-reactive substrate, Tris-(2-maleimidoethyl)amine (TMEA), to explore the contribution of the TM segments 6 and 12 of the human multidrug resistance P-glycoprotein (P-gp) during transport. TMEA is a trifunctional maleimide and sti
Autor:
T W, Loo, D M, Clarke
Publikováno v:
The Journal of biological chemistry. 274(50)
The drug-binding domain of the human multidrug resistance P-glycoprotein (P-gp) probably consists of residues from multiple transmembrane (TM) segments. In this study, we tested whether the amino acids in TM11 participate in binding drug substrates.
Autor:
T W, Loo, D M, Clarke
Publikováno v:
Biochemistry and cell biology = Biochimie et biologie cellulaire. 77(1)
The human multidrug resistance P-glycoprotein is an ATP-dependent drug pump that extrudes a broad range of cytotoxic agents from the cell. Its physiological role may be to protect the body from endogenous and exogenous cytotoxic agents. The protein h
Autor:
T W, Loo, D M, Clarke
Publikováno v:
The Journal of biological chemistry. 273(49)
Human P-glycoprotein is synthesized in HEK 293 cells as two major products: the 150-kDa core-glycosylated intermediate and the 170-kDa mature proteins. The 150- and 170-kDa proteins were not detected in mutants such as G341C. The major protein in thi
Autor:
T W, Loo, D M, Clarke
Publikováno v:
Methods in enzymology. 292
Publikováno v:
Journal of bioenergetics and biomembranes. 29(5)
The identification and characterization of the CFTR gene and protein have provided not only a major impetus to the dissection of the molecular pathophysiology of cystic fibrosis (CF) but also a new perspective on the structure and function of the lar
Autor:
T W, Loo, D M, Clarke
Publikováno v:
The Journal of biological chemistry. 270(37)
P-glycoprotein consists of two homologous halves, each composed of a transmembrane domain and a nucleotide-binding domain. In order to understand how the domains interact in P-glycoprotein, we expressed each domain as a separate polypeptide and teste
Publikováno v:
The Journal of biological chemistry. 269(51)
The insertion of Band 3, the human erythrocyte anion exchanger, into microsomal membranes was studied in an in vitro reticulocyte lysate translation system. Band 3 consists of a 43-kDa amino-terminal cytosolic domain and a carboxyl-terminal 52-kDa me