Zobrazeno 1 - 10
of 10
pro vyhledávání: '"T W, Harper"'
Autor:
Punit Marathe, Lisa Zhang, E. A. Dierks, Shu-Ying Chang, Q. Sun, A. D. Rodrigues, T. W. Harper
Publikováno v:
Drug Metabolism and Disposition. 39:1674-1679
1-Aminobenzotriazole (ABT) has been used widely as a nonselective in vitro and in vivo inhibitor of cytochrome P450 enzymes. To date, however, it has not been evaluated as an inhibitor of UDP-glucuronosyltransferase (UGT), sulfotransferase (SULT), an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::673ab00775774abfe441c5b6ac580518
https://doi.org/10.1124/dmd.111.039834
https://doi.org/10.1124/dmd.111.039834
Autor:
K S, Atwal, G J, Grover, S Z, Ahmed, F N, Ferrara, T W, Harper, K S, Kim, P G, Sleph, S, Dzwonczyk, A D, Russell, S, Moreland
Publikováno v:
Journal of Medicinal Chemistry. 36:3971-3974
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27e5171cdb47970990fb3009d55c220f
https://doi.org/10.1021/jm00076a027
https://doi.org/10.1021/jm00076a027
Autor:
D W, Phillipson, A A, Tymiak, J G, Tuttle, K S, Hartl, T W, Harper, M S, Bolgar, G T, Allen, M L, Ogletree
Publikováno v:
Journal of lipid mediators. 7(2)
Inhibition of thromboxane receptor radioligand binding to human platelet membranes has been employed as the basis for a radioreceptor assay designed to measure thromboxane receptor binding activity in samples of biological fluids. This method was use
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ea856d7786f0a54412b99be74b3871f5
https://pubmed.ncbi.nlm.nih.gov/8400117
https://pubmed.ncbi.nlm.nih.gov/8400117
Publikováno v:
Journal of Biological Chemistry. 261:5414-5418
Isolated rat heptocytes were found to metabolize leukotriene B4 (LTB4) to a number of products which could be separated by reverse phase high performance liquid chromatography (HPLC). After incubation of LTB4 with hepatocytes for 15 min, the known om
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4148404e0a8c0de6d44a96378ac93444
https://doi.org/10.1016/s0021-9258(19)57231-3
https://doi.org/10.1016/s0021-9258(19)57231-3
Publikováno v:
Journal of Biological Chemistry. 259:14437-14440
Isolated rat lungs perfused with physiological buffer containing leukotriene C4 were found to rapidly metabolize leukotriene C4 to leukotriene C4 sulfoxide, leukotriene D4, and leukotriene E4. Addition of leukotriene C4 to the recirculating perfusion
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::af7f71fbcc5a322c3f6056f815c57add
https://doi.org/10.1016/s0021-9258(17)42618-4
https://doi.org/10.1016/s0021-9258(17)42618-4
A single reaction product was formed during the incubation of 1.5 microM (5S,12R)-dihydroxy-6,14-cis-8,10-trans-[3H]icosatetraenoic acid (leukotriene B4, LTB4) for 30 min at 37 degrees C in 10 mM potassium phosphate buffer (pH 7.5) with 100 microM NA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c200d2c23da971a74bc2d1e6e3b6dfca
https://europepmc.org/articles/PMC397543/
https://europepmc.org/articles/PMC397543/
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 9(6)
Chiral secondary alcohols were treated with (S)-(-)-1-phenylethyl isocyanate. For each racemic alcohol, the resulting diastereomeric urethane derivatives were resolved on flexible fused-silica capillary GLC columns with retention times of 15 min or l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::fe3859024ef140f0c68b0d59767cacef
https://pubmed.ncbi.nlm.nih.gov/6120816
https://pubmed.ncbi.nlm.nih.gov/6120816
Publikováno v:
The Journal of biological chemistry. 259(23)
Isolated rat lungs perfused with physiological buffer containing leukotriene C4 were found to rapidly metabolize leukotriene C4 to leukotriene C4 sulfoxide, leukotriene D4, and leukotriene E4. Addition of leukotriene C4 to the recirculating perfusion
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::741b1163a4f2e14d6e793e2c86704a33
https://pubmed.ncbi.nlm.nih.gov/6094557
https://pubmed.ncbi.nlm.nih.gov/6094557
Publikováno v:
The Journal of biological chemistry. 261(12)
Isolated rat heptocytes were found to metabolize leukotriene B4 (LTB4) to a number of products which could be separated by reverse phase high performance liquid chromatography (HPLC). After incubation of LTB4 with hepatocytes for 15 min, the known om
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b2cfb095123429beec43741352d07379
https://pubmed.ncbi.nlm.nih.gov/3007501
https://pubmed.ncbi.nlm.nih.gov/3007501
Publikováno v:
The Journal of biological chemistry. 260(7)
The cytosolic fraction of human polymorphonuclear leukocytes precipitated with 60% ammonium sulfate produced 5-lipoxygenase products from [14C]arachidonic acid and omega-6 lipoxygenase products from both [14C]linoleic acid and, to a lesser extent, [1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::63f534fa9e575e8aba9d9786f2eea5eb
https://pubmed.ncbi.nlm.nih.gov/3920219
https://pubmed.ncbi.nlm.nih.gov/3920219