Zobrazeno 1 - 10 of 32 pro vyhledávání: '"T W, Guentert"'
1
Bioavailability of intramuscularly administered tenoxicam
Autor: T. W. Guentert, T. Stebler
Publikováno v: Biopharmaceutics & Drug Disposition. 14:483-490
Bioavailability of intramuscularly administered tenoxicam relative to single oral and relative to intravenous doses was determined in two separate randomized crossover studies. Twelve healthy volunteers (12 males, age 20-30 years) received a rapid in
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::257d64384bee635a9dd44a3fdaf093ab
https://doi.org/10.1002/bdd.2510140604
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2
Biopharmaceutical evaluation of carprofen following single intravenous, oral, and rectal doses in dogs
Autor: M. Schmitt, T. W. Guentert
Publikováno v: Biopharmaceutics & Drug Disposition. 11:585-594
Absorption and disposition characteristics of carprofen were compared in the dog after intravenous, oral, and rectal administrations. Rectal formulations included an aqueous solution and a suppository. Single doses of 100 mg carprofen were given in a
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6da861808e435e9a1e81d2f6ab86c3a
https://doi.org/10.1002/bdd.2510110704
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3
Monoamin-Oxidase-Hemmer
Autor: M. Gerlach, P. Riederer, J. R. Martin, R. Amrein, P. C. Waldmeier, R. Kettler, E. Borroni, A. Cesura, E. Grünblatt, K. Jorga, J. G. Richards, M. Da Prada, G. Laux, T. Becker, U. Müller, P. R. Bieck, M. P. Schmauss, T. W. Guentert
Publikováno v: Neuro-Psychopharmaka Ein Therapie-Handbuch ISBN: 9783211836477
Die Monoamin-Oxidase (MAO, EC 1.4.2.4; Amin: Sauerstoff-Oxidoreduktase [desaminierend]) ist ein relativ unspezifisches mitochondriales Enzym. Es metabolisiert monoaminerge Neurotransmitter (wie Adrenalin, Noradrenalin, Dopamin) und Neuromodulatoren (
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a51ce4f4277a7d3df6fbd7df4e69e94a
https://doi.org/10.1007/978-3-7091-6150-0_7
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4
A pharmacokinetic model to predict the PK interaction of L-dopa and benserazide in rats
Autor: S, Grange, N H, Holford, T W, Guentert
Publikováno v: Pharmaceutical research. 18(8)
To study the PK interaction of L-dopa/benserazide in rats.Male rats received a single oral dose of 80 mg/kg L-dopa or 20 mg/kg benserazide or 80/20 mg/kg L-dopa/benserazide. Based on plasma concentrations the kinetics of L-dopa, 3-O-methyldopa (3-OMD
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::9568cd8a68343018d6bd4dad08436856
https://pubmed.ncbi.nlm.nih.gov/11587490
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5
Relative bioavailability of oral dosage forms of tenoxicam
Autor: T W, Guentert, T, Stebler, L, Banken, R, Defoin, M, Schmitt
Publikováno v: Arzneimittel-Forschung. 44(9)
The bioavailability of tenoxicam (Ro 12-0068, Tilcotil, CAS 59804-37-4) from an effervescent tablet and an instant milk drink formulation relative to the commercial 20 mg tablet was investigated in a randomized cross-over study. Twelve healthy male v
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::2b7cad653a49929103d10c99257c8bd8
https://pubmed.ncbi.nlm.nih.gov/7986242
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6
Pharmacodynamics of lazabemide, a reversible and selective inhibitor of monoamine oxidase B
Autor: Nicholas H. G. Holford, R. Kettler, T. W. Guentert, J. Dingemanse
Publikováno v: Scopus-Elsevier
1. The inhibition of monoamine oxidase B (MAO-B) by lazabemide was measured in platelets collected from 35 young (19-36 years) and 40 older (60-78 years) healthy volunteers after single (100-300 mg) and multiple (100-350 mg twice daily) oral doses re
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::adc6921e8ec12e6f2015b8866bb0448c
https://europepmc.org/articles/PMC1364814/
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7
Monoamine oxidase-A: pharmacodynamics in humans of moclobemide, a reversible and selective inhibitor
Autor: L. Banken, Nicholas H. G. Holford, T. W. Guentert, J. Dingemanse
Publikováno v: Scopus-Elsevier
1. Single oral doses of 300, 450 and 600 mg moclobemide, a monoamine oxidase type A inhibitor, were administered in a cross-over design to eight healthy male volunteers. Plasma concentrations of the parent drug and of two monoamine metabolites (3,4-d
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27e0a57f78b982371f1218d25a5413fa
https://europepmc.org/articles/PMC1364898/
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9
Studies on the excretion of diazepam and nordazepam into milk for the prediction of milk-to-plasma drug concentration ratios
Autor: T, Stebler, T W, Guentert
Publikováno v: Pharmaceutical research. 9(10)
The influence of varying protein and fat content in milk of New Zealand White rabbits on the milk-to-plasma drug concentration (M/P) ratio of diazepam was studied. At various time points after littering, a bolus dose (1.5 mg/kg) followed by a 26-hr i
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b88ada8eccf92367d5070210baab8926
https://pubmed.ncbi.nlm.nih.gov/1448430
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10
Increase of plasma nonesterified fatty acid concentration and decrease of albumin binding affinity after intravenous injection of glycocholate-lecithin mixed micelles
Autor: T W, Guentert, B M, Frey, E, Luedin, S, Heinzl, R, Brodersen
Publikováno v: The Journal of laboratory and clinical medicine. 116(1)
Lipophilic drugs intended for intravenous use can be solubilized by mixed-micellar systems containing glycoholic acid and lecithin (MM). Our present studies determined the influence of such MM preparations on albumin binding of monoacetyldiaminodiphe
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::18b1cbaa3da6a4fb0272ad6917ca6afb
https://pubmed.ncbi.nlm.nih.gov/2376700
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