NMR indicates the N-termini of PSGL1 and CCR7 bind competitively to the chemokine CCL21

Autor: Robin N. Witt, Kaileigh S. Nickel, John R. Binns, Alexander M. Gray, Alyssa M. Hintz, Noah F. Kofron, Steven F. Steigleder, Francis C. Peterson, Christopher T. Veldkamp

Publikováno v: Biochemistry and Biophysics Reports, Vol 35, Iss , Pp 101524- (2023)

Chemokines are from a family of secreted cytokines that direct the trafficking of immune cells to coordinate immune responses. Chemokines are involved in numerous disease states, including responding to infections, autoimmune disorders, and cancer me

Externí odkaz: https://doaj.org/article/b7fdc898e9404bb6b0c6597b58871729

Factors affecting the decision-making process of using insect-based products in animal feed formulations

Autor: L. Gasco, S. Bellezza Oddon, G.W. Vandenberg, T. Veldkamp, I. Biasato

Publikováno v: Journal of Insects as Food and Feed. :1-12

Insect meals are promising alternative feed ingredients although their application is still not commonplace. Their inclusion requires the consideration of various factors to optimise growth, animal welfare, and feed costs. The insect meal form (whole

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2f6fa6dbca72cf9e93f93b1e3688caac
https://doi.org/10.3920/jiff2022.0164

Biased Signaling of CCL21 and CCL19 Does Not Rely on N-Terminal Differences, but Markedly on the Chemokine Core Domains and Extracellular Loop 2 of CCR7

Autor: Astrid S. Jørgensen, Olav Larsen, Edith Uetz-von Allmen, Michael Lückmann, Daniel F. Legler, Thomas M. Frimurer, Christopher T. Veldkamp, Gertrud M. Hjortø, Mette M. Rosenkilde

Publikováno v: Frontiers in Immunology, Vol 10 (2019)

Chemokine receptors play important roles in the immune system and are linked to several human diseases. Targeting chemokine receptors have so far shown very little success owing to, to some extent, the promiscuity of the immune system and the high de

Externí odkaz: https://doaj.org/article/adc9d50f5c624485a70b0f829f9929bd

Bioactive properties of insect products for monogastric animals : a review

Autor: T. Veldkamp, C. Govers, A. Paul, L. Dong

Publikováno v: Journal of Insects as Food and Feed 8 (2022) 9
Journal of Insects as Food and Feed, 8(9), 1027-1040

Insects or products derived from insects are considered as a valuable feed ingredient for aquaculture, poultry, and pigs but also exert possible secondary effects of health stimulators in livestock as reported in literature. Health benefits attribute

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d47c3f5af7e5ae83338663cc59e1b115
https://doi.org/10.3920/jiff2021.0031

Selective Boosting of CCR7-Acting Chemokines; Short Peptides Boost Chemokines with Short Basic Tails, Longer Peptides Boost Chemokines with Long Basic Tails

Autor: Emma Probst Brandum, Astrid Sissel Jørgensen, Marina Barrio Calvo, Katja Spiess, Francis C. Peterson, Zhang Yang, Brian F. Volkman, Christopher T. Veldkamp, Mette Marie Rosenkilde, Christoffer Knak Goth, Gertrud Malene Hjortø

Publikováno v: Brandum, E P, Jørgensen, A S, Calvo, M B, Spiess, K, Peterson, F C, Yang, Z, Volkman, B F, Veldkamp, C T, Rosenkilde, M M, Goth, C K & Hjortø, G M 2022, ' Selective Boosting of CCR7-Acting Chemokines; Short Peptides Boost Chemokines with Short Basic Tails, Longer Peptides Boost Chemokines with Long Basic Tails ', International Journal of Molecular Sciences, vol. 23, no. 3, 1397 . https://doi.org/10.3390/ijms23031397
International Journal of Molecular Sciences, Vol 23, Iss 1397, p 1397 (2022)
International Journal of Molecular Sciences; Volume 23; Issue 3; Pages: 1397

The chemokine receptor CCR7 and its ligands CCL19 and CCL21 regulate the lymph node homing of dendritic cells and naïve T-cells and the following induction of a motile DC-T cell priming state. Although CCL19 and CCL21 bind CCR7 with similar affiniti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63794b9193cedcc1292e12deb8ada8c6
https://curis.ku.dk/portal/da/publications/selective-boosting-of-ccr7acting-chemokines-short-peptides-boost-chemokines-with-short-basic-tails-longer-peptides-boost-chemokines-with-long-basic-tails(b1183c23-3140-496e-8a5c-c9a1c737b673).html