Zobrazeno 1 - 10
of 871
pro vyhledávání: '"T Valente"'
Autor:
Xue Yang, Zexuan Liu, Weiwei Tang, Uday P. Pratap, Alexia B. Collier, Kristin A. Altwegg, Rahul Gopalam, Xiaonan Li, Yaxia Yuan, Daohong Zhou, Zhao Lai, Yidong Chen, Gangadhara R. Sareddy, Philip T. Valente, Edward R. Kost, Suryavathi Viswanadhapalli, Ratna K. Vadlamudi
Publikováno v:
Molecular Oncology, Vol 18, Iss 9, Pp 2136-2156 (2024)
Endometrial carcinoma (ECa) is the fourth most common cancer among women. The oncogene PELP1 is frequently overexpressed in a variety of cancers, including ECa. We recently generated SMIP34, a small‐molecule inhibitor of PELP1 that suppresses PELP1
Externí odkaz:
https://doaj.org/article/004752a72a024ab7b87a815d9b033c3e
Autor:
Behnam Ebrahimi, Suryavathi Viswanadhapalli, Uday P. Pratap, Gopalam Rahul, Xue Yang, Prabhakar Pitta Venkata, Viktor Drel, Bindu Santhamma, Swapna Konda, Xiaonan Li, Alondra Lee Rodriguez Sanchez, Hui Yan, Gangadhara R. Sareddy, Zhenming Xu, Brij B. Singh, Philip T. Valente, Yidong Chen, Zhao Lai, Manjeet Rao, Edward R. Kost, Tyler Curiel, Rajeshwar R. Tekmal, Hareesh B. Nair, Ratna K. Vadlamudi
Publikováno v:
npj Precision Oncology, Vol 8, Iss 1, Pp 1-18 (2024)
Abstract Of all gynecologic cancers, epithelial-ovarian cancer (OCa) stands out with the highest mortality rates. Despite all efforts, 90% of individuals who receive standard surgical and cytotoxic therapy experience disease recurrence. The precise m
Externí odkaz:
https://doaj.org/article/9ac36726d5db494b89c1884b726a9b5c
Autor:
Katherine Noel, Ivan R. Wolf, David Hughes, Guilherme T. Valente, Aiming Qi, Yong-Ju Huang, Bruce D. L. Fitt, Henrik U. Stotz
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-15 (2024)
Abstract Understanding temperature-sensitivity of R gene-mediated resistance against apoplastic pathogens is important for sustainable food production in the face of global warming. Here, we show that resistance of Brassica napus cotyledons against L
Externí odkaz:
https://doaj.org/article/24fbe1ec09a44bea8f34c6ab2f245adf
Publikováno v:
BMC Genomics, Vol 24, Iss 1, Pp 1-4 (2023)
Externí odkaz:
https://doaj.org/article/322e15662acd4118926926535a978716
Autor:
Zixuan Yuan, Mahmud Arif Pavel, Hao Wang, Jerome C. Kwachukwu, Sonia Mediouni, Joseph Anthony Jablonski, Kendall W. Nettles, Chakravarthy B. Reddy, Susana T. Valente, Scott B. Hansen
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-12 (2022)
Super-resolution microscopy in cultured cells is employed to dissect the effect of hydroxychloroquine (HCQ) at the plasma membrane and HCQ directly perturbs clustering of the SARS-CoV-2 receptor ACE2 with endocytic lipids and PIP2 clusters.
Externí odkaz:
https://doaj.org/article/da95971dabb642e6b3a7d25f3abd74e0
Autor:
Danielle E. Lyons, Priti Kumar, Nadia R. Roan, Patricia A. Defechereux, Cedric Feschotte, Ulrike C. Lange, Niren Murthy, Pauline Sameshima, Eric Verdin, Julie A. Ake, Matthew S. Parsons, Avindra Nath, Sara Gianella, Davey M. Smith, Esper G. Kallas, Thomas J. Villa, Richard Strange, Betty Mwesigwa, Robert L. Furler O’Brien, Douglas F. Nixon, Lishomwa C. Ndhlovu, Susana T. Valente, Melanie Ott
Publikováno v:
Viruses, Vol 15, Iss 11, p 2171 (2023)
Despite remarkable progress, a cure for HIV-1 infection remains elusive. Rebound competent latent and transcriptionally active reservoir cells persevere despite antiretroviral therapy and rekindle infection due to inefficient proviral silencing. We p
Externí odkaz:
https://doaj.org/article/e4df173514554fe9824778fa69c18045
Autor:
Sonia Mediouni, Huihui Mou, Yuka Otsuka, Joseph Anthony Jablonski, Robert Scott Adcock, Lalit Batra, Dong-Hoon Chung, Christopher Rood, Ian Mitchelle S. de Vera, Ronald Rahaim Jr., Sultan Ullah, Xuerong Yu, Yulia A. Getmanenko, Nicole M. Kennedy, Chao Wang, Tu-Trinh Nguyen, Mitchell Hull, Emily Chen, Thomas D. Bannister, Pierre Baillargeon, Louis Scampavia, Michael Farzan, Susana T. Valente, Timothy P. Spicer
Publikováno v:
SLAS Discovery, Vol 27, Iss 1, Pp 8-19 (2022)
The severe acute respiratory syndrome coronavirus 2 responsible for COVID-19 remains a persistent threat to mankind, especially for the immunocompromised and elderly for which the vaccine may have limited effectiveness. Entry of SARS-CoV-2 requires a
Externí odkaz:
https://doaj.org/article/2347b83126774a29aab28c5d045a7718
Publikováno v:
Journal of Virus Eradication, Vol 8, Iss , Pp 100133- (2022)
Externí odkaz:
https://doaj.org/article/b1fbeaa0cbf4469da57adad513498fe8
Autor:
Weiwei Tang, Kumaraguruparan Ramasamy, Sureshkumar M. A. Pillai, Bindu Santhamma, Swapna Konda, Prabhakar Pitta Venkata, Logan Blankenship, Junhao Liu, Zexuan Liu, Kristin A. Altwegg, Behnam Ebrahimi, Uday P. Pratap, Xiaonan Li, Philip T. Valente, Edward Kost, Gangadhara R. Sareddy, Ratna K. Vadlamudi, Hareesh B. Nair, Rajeshwar R. Tekmal, Suryavathi Viswanadhapalli
Publikováno v:
Cell Death Discovery, Vol 7, Iss 1, Pp 1-10 (2021)
Abstract Endometrial cancer (EC) is the fourth most common cancer in women. Advanced-stage EC has limited treatment options with a poor prognosis. There is an unmet need for the identification of actionable drivers for the development of targeted the
Externí odkaz:
https://doaj.org/article/1cfca25be46f4749a68da61a6d728416
Autor:
Lijun Ling, Ana R. Leda, Nurjahan Begum, Rae Ann Spagnuolo, Angela Wahl, J. Victor Garcia, Susana T. Valente
Publikováno v:
Viruses, Vol 15, Iss 4, p 950 (2023)
HIV resistance to the Tat inhibitor didehydro-cortistatin A (dCA) in vitro correlates with higher levels of Tat-independent viral transcription and a seeming inability to enter latency, which rendered resistant isolates more susceptible to CTL-mediat
Externí odkaz:
https://doaj.org/article/3c292db9c9e04774aacfab1e3bec23ba