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Expression of human endogenous retrovirus k envelope transcripts in human breast cancer

Autor: F, Wang-Johanning, A R, Frost, G L, Johanning, M B, Khazaeli, A F, LoBuglio, D R, Shaw, T V, Strong

Publikováno v: Clinical cancer research : an official journal of the American Association for Cancer Research. 7(6)

We investigated the expression of human endogenous retroviral (HERV) sequences in breast cancer.Reverse transcription-PCR (RT-PCR) was used to examine expression of the envelope (env) region of ERV3, HERV-E4-1, and HERV-K in breast cancer cell lines,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::972999f408b56c2e87feb678f31e08d4
https://pubmed.ncbi.nlm.nih.gov/11410490

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A cancer gene therapy approach utilizing an anti-erbB-2 single-chain antibody-encoding adenovirus (AD21): a phase I trial

Autor: R D, Alvarez, M N, Barnes, J, Gomez-Navarro, M, Wang, T V, Strong, W, Arafat, R B, Arani, M R, Johnson, B L, Roberts, G P, Siegal, D T, Curiel

Publikováno v: Clinical cancer research : an official journal of the American Association for Cancer Research. 6(8)

The purpose of this Phase I study was to determine the feasibility of using an anti-erbB-2-encoding adenovirus (Ad21) to treat erbB-2-overexpressing ovarian cancer. Recurrent ovarian cancer patients were treated i.p. with Ad21 in dosages ranging from

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::4ce1c3336193692070aad1ba0131f095
https://pubmed.ncbi.nlm.nih.gov/10955787

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Selective gene delivery to head and neck cancer cells via an integrin targeted adenoviral vector

Autor: K, Kasono, J L, Blackwell, J T, Douglas, I, Dmitriev, T V, Strong, P, Reynolds, D A, Kropf, W R, Carroll, G E, Peters, R P, Bucy, D T, Curiel, V, Krasnykh

Publikováno v: Clinical cancer research : an official journal of the American Association for Cancer Research. 5(9)

In vivo cancer gene therapy approaches for squamous cell carcinoma of the head and neck (SCCHN) based on adenoviral vector-mediated gene delivery have been limited by the suboptimal efficacy of gene transfer to tumor cells. We hypothesized that this

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::040d352676d17c52fc04a4e54b42af78
https://pubmed.ncbi.nlm.nih.gov/10499635

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Polynucleotide immunization of nonhuman primates against carcinoembryonic antigen

Autor: R M, Conry, S A, White, P N, Fultz, M B, Khazaeli, T V, Strong, K O, Allen, D L, Barlow, S E, Moore, P N, Coan, I, Davis, D T, Curiel, A F, LoBuglio

Publikováno v: Clinical cancer research : an official journal of the American Association for Cancer Research. 4(11)

In preparation for a Phase I trial of DNA immunization against carcinoembryonic antigen (CEA) in patients with colorectal carcinoma, we have produced a single plasmid DNA encoding CEA and hepatitis B surface antigen (HBsAg) under transcriptional regu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::41ca215f681c2e0b4736b9860babced3
https://pubmed.ncbi.nlm.nih.gov/9829759

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Identification of a splice site mutation (2789 +5 GA) associated with small amounts of normal CFTR mRNA and mild cystic fibrosis

Autor: W E, Highsmith, L H, Burch, Z, Zhou, J C, Olsen, T V, Strong, T, Smith, K J, Friedman, L M, Silverman, R C, Boucher, F S, Collins, M R, Knowles

Publikováno v: Human mutation. 9(4)

A splicing mutation was identified at the +5 position of the splice donor site of exon 14b of CFTR in CF patients in a consanguineous family that is remarkable for unusually mild disease. Quantitative studies of nasal epithelial mRNA revealed that ho

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::add3d3464b09d6c90f4abd9513ea2810
https://pubmed.ncbi.nlm.nih.gov/9101293

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E1A RNA transcripts amplify adenovirus-mediated tumor reduction

Autor: L D, Dion, K T, Goldsmith, T V, Strong, G, Bilbao, D T, Curiel, R I, Garver

Publikováno v: Gene therapy. 3(11)

Previous work by this group has established that E1-defective, recombinant adenoviruses can be replication-enabled by the codelivery of a plasmid encoding the deleted E1 functions, a strategy now designated conditional replication-enablement system f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::68b1f8ab38bf736076ea94396e5fc770
https://pubmed.ncbi.nlm.nih.gov/9044743

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Novel missense mutation (G314R) in a cystic fibrosis patient with hepatic failure

Autor: S Z, Nasr, T V, Strong, M K, Mansoura, D C, Dawson, F S, Collins

Publikováno v: Human mutation. 7(2)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e8b814787651aac4a4e3d3afa148d1f6
https://pubmed.ncbi.nlm.nih.gov/8829633

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Identification of a CFTR frameshift mutation (1013 delAA) in trans to delta F508 in a pancreatic sufficient cystic fibrosis patient

Autor: S Z, Nasr, T V, Strong, F S, Collins

Publikováno v: Human molecular genetics. 3(11)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::0ddffc9fb81bf037f7dd71ff77db1ac2
https://pubmed.ncbi.nlm.nih.gov/7533026

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Evidence for tau expression in cells of monocyte lineage and its in vitro phosphorylation by v-fms kinase

Autor: H, Kim, T V, Strong, S J, Anderson

Publikováno v: Oncogene. 6(6)

The v-fms encoded kinase, which is known to associate with cytoskeletal elements, was shown to phosphorylate histiocytic proteins that had physical and immunological attributes in common with tau. Tau is a microtubule associated protein that is aberr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::90e89c7af6ce57f391f73e56778f8b5f
https://pubmed.ncbi.nlm.nih.gov/1829806

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