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Inhibition of platelet aggregation by monoclonal antibodies against glycoprotein IIb–IIIa complex

Autor: A. V. Mazurov, T. V. Byzova, T. N. Vlasik

Publikováno v: Bulletin of Experimental Biology and Medicine. 118:1102-1105

Monoclonal antibodies CRC64 are obtained against Ca2+-dependent glycoprotein IIb–IIIa complex of the platelet membrane which possess the ability to inhibit completely fibrinogen-dependent platelet aggregation. CRC64 is directed against the epitope

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6ef6f23f3e368a6e7c27ff7d14015eb2
https://doi.org/10.1007/bf02446470

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Safety, inhibition of platelet aggregation and pharmacokinetics of Fab'2 fragments of the anti-glycoprotein IIb-IIIa monoclonal antibody FRaMon in high-risk coronary angioplasty

Autor: A. V. Semenov, S. G. Khaspekova, Pevzner Dv, Antonova Oa, T. N. Vlasik, Samko An, I. I. Staroverov, A. V. Mazurov, M Ya Ruda, T. V. Byzova

Publikováno v: Platelets. 13(8)

The purpose of the study was to evaluate safety, effects on platelet aggregation and pharmacokinetics of F(ab')(2) fragments of anti-glycoprotein (GP) IIb-IIIa murine monoclonal antibody FRaMon (F(ab')(2) FRaMon) upon its intravenous administration i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abfba69cfc731a2546c4d17da784c386
https://pubmed.ncbi.nlm.nih.gov/12487780

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[Inhibition of thrombocyte aggregation by F(ab')2-fragments of monoclonal antibodies FraMon (CRC64) to glycoproteins IIb-IIIa]

Autor: A V, Mazurov, D V, Pevzner, S G, Khaspekova, O A, Dudnik, T V, Byzova, T N, Vlasik, V N, Bakharev, M Iu, Pistsov, I I, Staroverov, M Ia, Ruda

Publikováno v: Terapevticheskii arkhiv. 73(9)

To study the effects of F(ab')2 fragments of the monoclonal antibody (monAB) FRaMon against glycoproteins (GP) IIb-IIIa on platelet aggregating activity in vitro and after injection to healthy volunteers.In vitro experiments were performed to study e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::63966ac96a190e4ac8369fccb2b1771f
https://pubmed.ncbi.nlm.nih.gov/11642086

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AlphaIIbbeta3 and its antagonism at the new millennium

Autor: E F, Plow, C S, Cierniewski, Z, Xiao, T A, Haas, T V, Byzova

Publikováno v: Thrombosis and haemostasis. 86(1)

Because of its major role in regulating platelet functions and its prominence on the cell surface, integrin alphaIIbbeta3 has been the subject of intensive investigations. Such studies have provided substantial insights into its structure-function re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e1acb0dcffc74f0ab199920c352f49b4
https://pubmed.ncbi.nlm.nih.gov/11487023

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A mechanism for modulation of cellular responses to VEGF: activation of the integrins

Autor: T V, Byzova, C K, Goldman, N, Pampori, K A, Thomas, A, Bett, S J, Shattil, E F, Plow

Publikováno v: Molecular cell. 6(4)

Many similarities exist in the cellular responses elicited by VEGF and governed by integrins. Here, we identify a basis for these interrelationships: VEGF activates integrins. VEGF enhanced cell adhesion, migration, soluble ligand binding, and adenov

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::9dd50e54b9f5dea4aa999fa5d8f5b0a1
https://pubmed.ncbi.nlm.nih.gov/11090623

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Role of integrin alpha(v)beta3 in vascular biology

Autor: T V, Byzova, R, Rabbani, S E, D'Souza, E F, Plow

Publikováno v: Thrombosis and haemostasis. 80(5)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::75e3572eb03ea281192bab1051d809e8
https://pubmed.ncbi.nlm.nih.gov/9843163

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Networking in the hemostatic system. Integrin alphaiibbeta3 binds prothrombin and influences its activation

Autor: T V, Byzova, E F, Plow

Publikováno v: The Journal of biological chemistry. 272(43)

Prothrombin activation is a pivotal event in thrombosis and hemostasis because thrombin can mediate fibrin formation and can activate and aggregate platelets. Platelet aggregation depends upon the binding of adhesive proteins to integrin alphaIIbbeta

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a46c92869288c9b89fb3927582e7af28
https://pubmed.ncbi.nlm.nih.gov/9341161

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[Interaction of a monoclonal antibody to P-selectin with activated platelets and endothelial cells. Heterogeneity of expressing P-selectin in human aorta endothelial cells]

Autor: T V, Byzova, Iu A, Romanov, T N, Blasik, A V, Mazurov

Publikováno v: Biokhimiia (Moscow, Russia). 60(8)

Monoclonal antibody (MAb) CRC81 against P-selectin, a membrane cell adhesion protein of platelets and endothelial cells (EC), has been obtained and characterized. The antibody selectively interacted with the surface of activated platelets and EC due

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::80c7acab71c6854507c21eaba66aecdc
https://pubmed.ncbi.nlm.nih.gov/7578581

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