Zobrazeno 1 - 10
of 39
pro vyhledávání: '"T Thanga Mariappan"'
Autor:
Kunal S Taskar, T Thanga Mariappan, Vishwanath Kurawattimath, Shashyendra Singh Gautam, TV Radhakrishna Mullapudi, Srikanth K Sridhar, Raja Reddy Kallem, Punit Marathe, Sandhya Mandlekar
Publikováno v:
Journal of Central Nervous System Disease, Vol 9 (2017)
The role of uptake transporter (organic anion–transporting polypeptide [Oatp]) in the disposition of a P-glycoprotein (P-gp) substrate (digoxin) at the barriers of central nervous system, namely, the blood-brain barrier (BBB), blood-spinal cord bar
Externí odkaz:
https://doaj.org/article/817b525e2fc84613aeb24fa312a48c24
Autor:
Dilip Kumar Singh, Ankit Balhara, Mayur K. Ladumor, Manikandan Ramalingam, Hemant Bhutani, Bhagwat Prasad, Moolchand Kurmi, Ravi P. Shah, Amrit Paudel, Sheena Sharma, T. Thanga Mariappan, Dattatray Modhave, Surapuraju Pavankumarraju
Publikováno v:
Journal of Pharmaceutical Sciences. 111:1224-1231
This commentary presents contributions and accomplishments of Professor Saranjit Singh, National Institute of Pharmaceutical Education and Research (NIPER), SAS Nagar, India, to pharmaceutical research and education. Prof. Singh completed his success
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2d7c843d14363b6b95b6f9530cbf3f1
https://doi.org/10.1016/j.xphs.2021.10.024
https://doi.org/10.1016/j.xphs.2021.10.024
Autor:
Vinay K. Holenarsipur, Yurong Lai, W. Griffith Humphreys, Jim Zheng, Jennifer Tang, T. Thanga Mariappan, Xiaofeng Zhao, Erika Panfen, Hong Shen, Yueping Zhang
Publikováno v:
Drug Metabolism and Disposition. 49:1063-1069
As an expansion investigation of drug-drug interaction (DDI) from previous clinical trials, additional plasma endogenous metabolites were quantitated in the same subjects to further identify the potential biomarkers of organic anion transporter (OAT)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20248cc537880920ccd0a7a436b6f058
https://doi.org/10.1124/dmd.121.000486
https://doi.org/10.1124/dmd.121.000486
Autor:
Mark Fereshteh, Xiao Zhu, Tai-An Lin, Prabhakar Rajanna, Cherney Emily Charlotte, Aravind Anandam, Xin Li, Derrick Maley, Liping Zhang, Gopal Dhar, Aaron Balog, Robert M. Borzilleri, Johnni Gullo-Brown, T. Thanga Mariappan, Kathy Johnston-Allegretto, Christine Huang, Venkata Murali, John T. Hunt, Sandeep Mahankali, Gregory D. Vite, Lisa M. Kopcho, Shweta Padmanabhan, Sarah C. Traeger
Publikováno v:
ACS Med Chem Lett
[Image: see text] Indoleamine 2,3-dioxygenase 1 (IDO1) has been identified as a target for small-molecule immunotherapy for the treatment of a variety of cancers including renal cell carcinoma and metastatic melanoma. This work focuses on the identif
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c69bf6be584624b416a38e3f63d582b0
https://doi.org/10.1021/acsmedchemlett.1c00014
https://doi.org/10.1021/acsmedchemlett.1c00014
Autor:
L.V.J. Sankara Sivaprasad, Bokka Venkata Murali, T. Thanga Mariappan, Sushma Basavanthappa, Avinash Annasao Hadambar, Vijaykumar Kuchibhotla, Avisek Deyati, Bradley A. Zinker, Gowtham Raj Gunti, Manjunath Ramarao, Sagnik Chatterjee, Shashyendra Singh Gautam, Yueping Zhang, Tanvi Naik, Hong Shen, Sambuddho Mukherjee, Michael Sinz
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 376:29-39
Expression and functional changes in the organic anion transporting polypeptide (OATP)-multidrug resistance-associated protein (MRP) axis of transporters are well reported in patients with nonalcoholic steatohepatitis (NASH). These changes can impact
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c586217f3e68fc4669c5919c8c6bfed3
https://doi.org/10.1124/jpet.120.000291
https://doi.org/10.1124/jpet.120.000291
Autor:
Joel C. Barrish, John Hynes, Ajay Saxena, Natesan Murugesan, Dianlin Xie, Anjaneya Chimalakonda, Stefan Ruepp, Mitalee Das, Richard Rampulla, Durgarao Kantheti, Chunhong Yan, Julie Carman, Jignesh Nagar, Siva Subramani, Qian Ruan, William J. Pitts, Rajeev S. Bhide, Paul A. Elzinga, Venkatram Reddy Paidi, John S. Sack, Mark Fereshteh, Thangavel Soodamani, Amrita Jha Mukherjee, T. Thanga Mariappan, Ramesh Kumar Sistla, Kaushik Ghosh, Debarati Mazumder, Kamalavenkatesh Palanisamy, Deborah A. Holloway, Susan E. Kiefer, John A. Newitt, Satheesh Kesavan Nair, Polimera Subba Rao, Shailesh Dudhgoankar, Percy H. Carter, Xin Li, Srinivas Maddi, S. Pon Saravanakumar, Sreekantha Ratna Kumar, Sucharita Bose
Publikováno v:
ACS Med Chem Lett
[Image: see text] IRAK4 is an attractive therapeutic target for the treatment of inflammatory conditions. Structure guided optimization of a nicotinamide series of inhibitors has been expanded to explore the IRAK4 front pocket. This has resulted in t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24bbdf7e3f4256a866250ac0c4fba45e
https://doi.org/10.1021/acsmedchemlett.0c00082
https://doi.org/10.1021/acsmedchemlett.0c00082
Autor:
Ravindranath Reddy Gilibili, Vishwanath Kurawattimath, Bokka Venkata Murali, Yurong Lai, T. Thanga Mariappan, Hong Shen, Sagnik Chatterjee
Publikováno v:
Pharmaceutics, Vol 10, Iss 3, p 125 (2018)
Previously we reported that coproporphyrin-I (CP-I) is an optimal probe substrate for multidrug resistance-associated protein 2 (MRP2), and stimulation of MRP2-mediated transport is probe substrate-dependent. In the present investigation, we assessed
Externí odkaz:
https://doaj.org/article/5d255df6613d4527909558d783ee0cbd
Autor:
Lisa M. Kopcho, Johnni Gullo-Brown, Shweta Padmanabhan, Pattasseri Shabeerali, Arvind Mathur, Prabhakar Rajanna, Lorell Discenza, Liping Zhang, Zhenqiu Hong, Sarah C. Traeger, Zheng Yang, Cherney Emily Charlotte, Richard Rampulla, David K. Williams, Gopal Dhar, Kimberly A. Foster, James Kempson, Derrick Maley, Mary F. Grubb, Xiao Zhu, Xin Li, Weifang Shan, Robert M. Borzilleri, Diane Delpy, Kevin Stefanski, T. Thanga Mariappan, Gregory D. Vite, Kathy A. Johnston, Audris Huang, Asoka Ranasinghe, Mark Fereshteh, Aravind Anandam, Steven P. Seitz, John T. Hunt, Aaron Balog, Celia D’Arienzo, Anuradha Gupta, Tai-An Lin, Roshan Y. Nimje, Weiwei Guo, Christine Huang, Venkata Murali, Sandeep Mahankali
Publikováno v:
ACS Med Chem Lett
[Image: see text] IDO1 inhibitors have shown promise as immunotherapies for the treatment of a variety of cancers, including metastatic melanoma and renal cell carcinoma. We recently reported the identification of several novel heme-displacing IDO1 i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0f0d7f8a891846e7ad07844b139d549
https://europepmc.org/articles/PMC8274105/
https://europepmc.org/articles/PMC8274105/
Autor:
Hamza Kandoussi, T. Thanga Mariappan, Jianing Zeng, Vinay K. Holenarsipur, Yueping Zhang, Michael Sinz, Hong Shen
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 48(10)
Probenecid (PROB) is a clinical probe inhibitor of renal organic anion transporter (OAT) 1 and OAT3 that inhibits in vitro activity of hepatic drug transporters OATP1B1 and OATP1B3. It was hypothesized that PROB could potentially affect the dispositi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::699875fec11144f67a9ef27720f3ed52
https://pubmed.ncbi.nlm.nih.gov/32723847
https://pubmed.ncbi.nlm.nih.gov/32723847
Autor:
T. Thanga Mariappan, Petia Shipkova, Joseph L. Cantone, Prabhakar Rajanna, Hong Shen, Jinping Gan, W. Griffith Humphreys, Shashyendra Singh Gautam, Dieter M. Drexler, Yueping Zhang, Vinay K. Holenarsipur, Punit Marathe
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 368:136-145
Plasma pyridoxic acid (PDA) and homovanillic acid (HVA) were recently identified as novel endogenous biomarkers of organic anion transporter (OAT) 1/3 function in monkeys. Consequently, this clinical study assessed the dynamic changes and utility of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90699d7ec3940e0a5942d9f499048583
https://doi.org/10.1124/jpet.118.252643
https://doi.org/10.1124/jpet.118.252643