Zobrazeno 1 - 10
of 61
pro vyhledávání: '"T Soulis"'
Autor:
E Scalbert, Josephine M. Forbes, Vicki Thallas, S Sastra, Mark E. Cooper, T Soulis, Ian A. Darby
Publikováno v:
Diabetologia. 43:660-664
Aims/hypothesis. Advanced glycation is postulated to have a pivotal role in mediating diabetic vascular complications. The emergence of thiazolium compounds such as N-phenacylthiazolium bromide which cleave preformed advanced glycation end products (
Autor:
Sianna Panagiotopoulos, Dominique T. Nguyen, George Jerums, Sherif Youssef, T Soulis, Mark E. Cooper
Publikováno v:
Kidney International. 55:907-916
Effect of diabetes and aminoguanidine therapy on renal advanced glycation end-product binding.BackgroundAdvanced glycation end-products (AGEs) have been implicated in the pathogenesis of diabetic nephropathy, and aminoguanidine (AG) has been shown to
Publikováno v:
Diabetologia. 41:1419-1425
A close association of neuronal nitric oxide synthase-immunoreactive (nNOS-IR) neurons with the retinal vasculature has been reported and it is proposed that activation of these neurons could be the mechanism by which retinal blood flow and metabolis
Autor:
Ole J. Bjerrum, T Soulis, Vicki Thallas, George Jerums, Mark E. Cooper, Sianna Panagiotopoulos, S Sastra
Publikováno v:
Diabetologia. 40:1141-1151
Advanced glycation end products (AGEs) have previously been shown to be increased in the diabetic kidney. Aminoguanidine, an inhibitor of advanced glycation, has been shown to attenuate the development of AGEs as well as the progression of renal dise
Autor:
T Soulis, Richard E. Gilbert, Jonathan R. Rumble, Mariusz Jasik, George Jerums, Leonard L. Wu, Sherif Youssef, Mark E. Cooper, Alison J. Cox
Publikováno v:
Journal of Clinical Investigation. 99:1016-1027
The accelerated formation of advanced glycation end products (AGEs) and the overexpression of transforming growth factor beta (TGF-beta) have both been implicated in the pathogenesis of diabetic microvascular and macrovascular complications. Previous
Summary Recently, we demonstrated that nitric oxide synthase immunoreactive (NOS-IR) neurons are closely associated with the retinal vasculature and have proposed that these neurons are the mechanism by which retinal blood flow and metabolism are lin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::afaa85e844c0ec926aa240bcf242ab46
https://doi.org/10.1533/9781845698447.7.279
https://doi.org/10.1533/9781845698447.7.279
Over the last 10 years, the process of advanced glycation endproduct (AGE) formation has been implicated in the pathogenesis of many of the longterm complications of diabetes. Since the restoration of blood glucose levels to normal remains difficult,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5df61c2838b871b114d356c2252ab360
https://doi.org/10.1533/9781845698393.4.319
https://doi.org/10.1533/9781845698393.4.319
Publikováno v:
Journal of the American Society of Nephrology : JASN. 12(10)
Profibrotic cytokines and the formation of advanced-glycation end products (AGE) have both been implicated in the pathogenesis of glomerulosclerosis in diabetic kidney disease. However, tubulointerstitial pathology is also an important determinant of
Autor:
Vicki Thallas, DM Long, Mark E. Cooper, Josephine M. Forbes, D Wagle, T Soulis, George Jerums, S Vasan, Sianna Panagiotopoulos
Publikováno v:
Diabetologia. 44(1)
Aims/hypothesis. ALT-946, an inhibitor of advanced glycation with a minimal inhibitory effect on nitric oxide synthase, was compared with aminoguanidine in experimental diabetic nephropathy.¶Methods. In vitro and in vivo assays were used to assess t