Zobrazeno 1 - 10
of 33
pro vyhledávání: '"T Simon Futers"'
Autor:
Vincenza Caolo, Marjolaine Debant, Naima Endesh, T Simon Futers, Laeticia Lichtenstein, Fiona Bartoli, Gregory Parsonage, Elizabeth AV Jones, David J Beech
Publikováno v:
eLife, Vol 9 (2020)
Mechanical force is a determinant of Notch signalling but the mechanism of force detection and its coupling to Notch are unclear. We propose a role for Piezo1 channels, which are mechanically-activated non-selective cation channels. In cultured micro
Externí odkaz:
https://doaj.org/article/7090cc8a18db409dbe9d55c0618c0087
Autor:
Eulashini Chuntharpursat-Bon, Oleksandr V. Povstyan, Melanie J. Ludlow, David J. Carrier, Marjolaine Debant, Jian Shi, Hannah J. Gaunt, Claudia C. Bauer, Alistair Curd, T. Simon Futers, Paul D. Baxter, Michelle Peckham, Stephen P. Muench, Antony Adamson, Neil Humphreys, Sarka Tumova, Robin S. Bon, Richard Cubbon, Laeticia Lichtenstein, David J. Beech
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-18 (2023)
The PIEZO1 channel and the PECAM1 cell adhesion molecule interact and PIEZO1 cooperates with PECAM1 and CDH5 cell junctions during mechanical stress.
Externí odkaz:
https://doaj.org/article/ec77feaa25314fbeac8b7a91697307ac
Autor:
Fiona Bartoli, Marjolaine Debant, Eulashini Chuntharpursat-Bon, Elizabeth L. Evans, Katie E. Musialowski, Gregory Parsonage, Lara C. Morley, T. Simon Futers, Piruthivi Sukumar, T. Scott Bowen, Mark T. Kearney, Laeticia Lichtenstein, Lee D. Roberts, David J. Beech
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 5 (2022)
Piezo1 forms mechanically activated nonselective cation channels that contribute to endothelial response to fluid flow. Here we reveal an important role in the control of capillary density. Conditional endothelial cell–specific deletion of Piezo1 i
Externí odkaz:
https://doaj.org/article/7a5506da60ec4fa4ab0afb685437f3d2
Autor:
Jian Shi, Adam J. Hyman, Dario De Vecchis, Jiehan Chong, Laeticia Lichtenstein, T. Simon Futers, Myriam Rouahi, Anne Negre Salvayre, Nathalie Auge, Antreas C. Kalli, David J. Beech
Publikováno v:
Cell Reports, Vol 33, Iss 1, Pp 108225- (2020)
Summary: Endogenous PIEZO1 channels of native endothelium lack the hallmark inactivation often seen when these channels are overexpressed in cell lines. Because prior work showed that the force of shear stress activates sphingomyelinase in endotheliu
Externí odkaz:
https://doaj.org/article/f6b344136b464cb480bd078a6a9a4088
Autor:
Baptiste Rode, Jian Shi, Naima Endesh, Mark J. Drinkhill, Peter J. Webster, Sabine J. Lotteau, Marc A. Bailey, Nadira Y. Yuldasheva, Melanie J. Ludlow, Richard M. Cubbon, Jing Li, T. Simon Futers, Lara Morley, Hannah J. Gaunt, Katarzyna Marszalek, Hema Viswambharan, Kevin Cuthbertson, Paul D. Baxter, Richard Foster, Piruthivi Sukumar, Andrew Weightman, Sarah C. Calaghan, Stephen B. Wheatcroft, Mark T. Kearney, David J. Beech
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
The mechanisms that regulate the body’s response to exercise are poorly understood. Here, Rode et al. show that the mechanically activated cation channel Piezo1 is a molecular sensor of physical exercise in the endothelium that triggers endothelial
Externí odkaz:
https://doaj.org/article/7f62f67aa840473d94edc1b8db9c890a
Autor:
Amanda D. V. MacCannell, Anna Whitehead, Klaus K. Witte, T. Simon Futers, Amy Moran, Lee D. Roberts
Publikováno v:
International journal of obesity (2005)
Objective The prevalence of obesity is growing globally. Adiposity increases the risk for metabolic syndrome, type 2 diabetes and cardiovascular disease. Adipose tissue distribution influences systemic metabolism and impacts metabolic disease risk. T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d42bdc645f56061b66a7cdd0f422dd35
http://europepmc.org/articles/PMC8310795
http://europepmc.org/articles/PMC8310795
Autor:
Fiona Bartoli, Elizabeth L. Evans, Nicola M. Blythe, Leander Stewart, Eulashini Chuntharpursat-Bon, Marjolaine Debant, Katie E. Musialowski, Laeticia Lichtenstein, Gregory Parsonage, T. Simon Futers, Neil A. Turner, David J. Beech
Publikováno v:
Cells; Volume 11; Issue 7; Pages: 1199
PIEZO1 is a subunit of mechanically-activated, nonselective cation channels. Gain-of-function PIEZO1 mutations are associated with dehydrated hereditary stomatocytosis (DHS), a type of anaemia, due to abnormal red blood cell function. Here, we hypoth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67eafb3f4140b02253b037e76e3afeda
Autor:
Gregory Parsonage, Neil E. Humphreys, Oleksandr V. Povstyan, Dario De Vecchis, Antony Adamson, Fraser L. Macrae, T. Simon Futers, Melanie J. Ludlow, Laeticia Lichtenstein, David J. Beech, Antreas C. Kalli, Elizabeth L. Evans
Publikováno v:
Blood
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f82cbc0518e14824790886cfd8e76b93
https://doi.org/10.1182/blood.2019004174
https://doi.org/10.1182/blood.2019004174
Autor:
Karen E Hemmings, Natalie J Haywood, Katherine I Bridge, Andrew Walker, Hema Viswambharan, Katie J. Simmons, Richard M Cubbon, Karen E. Porter, Ajay M. Shah, Jane Brown, David J. Beech, Emily R. Clark, Natallia Makava, Mark T. Kearney, Yilizila Abudushalamu, Khalid M. Naseem, Stephen B. Wheatcroft, Helen Imrie, Anna Skromna, V Kate Gatenby, Naima Endesh, Nadira Yuldasheva, Piruthivi Sukumar, T. Simon Futers, Paul A. Cordell
Publikováno v:
Circulation Research
Supplemental Digital Content is available in the text.
Rationale: A hallmark of type 2 diabetes is insulin resistance, which leads to increased endothelial cell (EC) production of superoxide and a simultaneous reduction in the availability of th
Rationale: A hallmark of type 2 diabetes is insulin resistance, which leads to increased endothelial cell (EC) production of superoxide and a simultaneous reduction in the availability of th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9060219ad1bcabd2b1ca0baba0d5a0bb
https://eprints.whiterose.ac.uk/177316/16/CIRCRESAHA.121.319517.pdf
https://eprints.whiterose.ac.uk/177316/16/CIRCRESAHA.121.319517.pdf
Autor:
Laeticia Lichtenstein, Jian Shi, Myriam Rouahi, Nathalie Augé, Jiehan Chong, Adam J. Hyman, David J. Beech, Dario De Vecchis, T. Simon Futers, Antreas C. Kalli, Anne Negre Salvayre
Publikováno v:
Cell Reports, Vol 33, Iss 1, Pp 108225-(2020)
Cell Reports
Cell Reports
Summary Endogenous PIEZO1 channels of native endothelium lack the hallmark inactivation often seen when these channels are overexpressed in cell lines. Because prior work showed that the force of shear stress activates sphingomyelinase in endothelium
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14f617e95adfb6511becfddf686dd716
https://eprints.whiterose.ac.uk/165506/15/1-s2.0-S2211124720312146-main.pdf
https://eprints.whiterose.ac.uk/165506/15/1-s2.0-S2211124720312146-main.pdf