Výsledky vyhledávání

Phase I and pharmacokinetic study of oral fludarabine phosphate in relapsed indolent B-cell non-Hodgkin's lymphoma

Autor: T. Hotta, T. Seriu, Yasutsuna Sasaki, Takashi Watanabe, Kensei Tobinai, Yoshiaki Ogawa, Michinori Ogura, Hironobu Minami, Yasuo Morishima

Publikováno v: Annals of Oncology. 17:330-333

Background: The primary objective of this study was to investigate the tolerability, efficacy and pharmacokinetic profile of oral fludarabine phosphate in relapsed patients with indolent B-cell non-Hodgkin's lymphoma (B-NHL). Patients and methods: Pa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56a22177aae64132ba449c470a219305
https://doi.org/10.1093/annonc/mdj069

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Immunoglobulin κ gene rearrangements between the κ deleting element and Jκ recombination signal sequences in acute lymphoblastic leukemia and normal hematopoiesis

Autor: C. R. Bartram, T Seriu, TE Hansen-Hagge, Y Stark

Publikováno v: Leukemia. 14:671-674

The kappa deleting element (kappaDE) located 24 kb downstream of the Ckappa gene segment mediates the deletion of Ckappa and the Jkappa-Ckappa Intron enhancer, which results in allelic exclusion of the immunoglobulin kappa light chain locus. We here

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30a1f8efe142b6f96b79d5ca0e58ade5
https://doi.org/10.1038/sj.leu.2401745

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Homozygous deletions at 9p21 in childhood acute lymphoblastic leukemia detected by microsatellite analysis

Autor: H P Koeffler, Seisho Takeuchi, T Seriu, Isao Miyoshi, Park S, J Slater, Koike M, Claus R. Bartram

Publikováno v: Leukemia. 11:1636-1640

To gain a fuller understanding of the role of deletions of chromosome 9 in the development of childhood acute lymphoblastic leukemia (ALL), we performed detailed deletional mapping of chromosome 9 in 54 primary ALL samples with matched normal DNA usi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6f9213f3aa1d3ad893aec5ad2c5d23a
https://doi.org/10.1038/sj.leu.2400817

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TEL/AML-1 dimerizes and is associated with a favorable outcome in childhood acute lymphoblastic leukemia

Autor: TW McLean, S Ringold, D Neuberg, K Stegmaier, R Tantravahi, J Ritz, HP Koeffler, S Takeuchi, JW Janssen, T Seriu, CR Bartram, SE Sallan, DG Gilliland, TR Golub

Publikováno v: Blood. 88:4252-4258

Polymerase chain reaction-based screening of childhood acute lymphoblastic leukemia (ALL) samples showed that a TEL/AML1 fusion transcript was detected in 27% of all cases, representing the most common known gene rearrangement in childhood cancer. Th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::25c1e3f52274820409dae16346db1a33
https://doi.org/10.1182/blood.v88.11.4252.bloodjournal88114252

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TEL/AML-1 dimerizes and is associated with a favorable outcome in childhood acute lymphoblastic leukemia

Autor: T. Seriu, Stephen E. Sallan, Donna Neuberg, C. R. Bartram, J. W. G. Janssen, D G Gilliland, Jerome Ritz, Ramana Tantravahi, T. W. Mclean, S. Takeuchi, S. Ringold, H. P. Koeffler, Todd R. Golub, Kimberly Stegmaier

Publikováno v: Blood. 88:4252-4258

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f500f39b4246225ec6ca1be494ac6894
https://doi.org/10.1182/blood.v88.11.4252.4252

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Acute lymphoblastic leukemia of childhood: identification of two distinct regions of deletion on the short arm of chromosome 12 in the region of TEL and KIP1

Autor: A Reiter, M Schrappe, Claus R. Bartram, Seisho Takeuchi, Carl W. Miller, Naoki Mori, J Slater, T Seriu, I. Miyoshi, M Zimmerann, H P Koeffler

Publikováno v: Blood. 87:3368-3374

Cytogenetic analysis of acute lymphoblastic leukemia (ALL) of childhood identified nonrandom chromosomal abnormalities of the short arm of chromosome 12. The alterations include deletions that are thought to be indicative of the presence of a tumor s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6cf549b3547e1097d0684d8229fdf3ac
https://doi.org/10.1182/blood.v87.8.3368.bloodjournal8783368

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Analysis of a family of cyclin-dependent kinase inhibitors: p15/MTS2/INK4B, p16/MTS1/INK4A, and p18 genes in acute lymphoblastic leukemia of childhood

Autor: JW Janssen, T Seriu, CR Bartram, Juerg Schwaller, A Tobler, M. Zimmermann, A. Reiter, Seisho Takeuchi, WD Ludwig, Carl W. Miller

Publikováno v: Blood. 86:755-760

A newly recognized family of proteins that inhibit cyclin-dependent kinases (CDKs) termed cyclin-dependent kinase inhibitors (CDKI) have an important role in regulation of cell-cycle progression. A subfamily of these CDKIs (p15INK4B/MTS2, p16INK4/MTS

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::817c57ca1a3736597ba59f9933ded49a
https://doi.org/10.1182/blood.v86.2.755.bloodjournal862755

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Clinical significance of aberrant DNA methylation in childhood acute lymphoblastic leukemia

Autor: Martin Zimmermann, Naoki Komatsu, Seisho Takeuchi, Claus R. Bartram, H. Phillip Koeffler, T Seriu, Martin Schrappe, Masahide Matsushita, Takayuki Ikezoe

Publikováno v: Leukemia research. 35(10)

Methylation profile was analyzed in ninety-five patients with childhood acute lymphoblastic leukemia (ALL). Methylation of both MGMT and p16 genes were associated with higher age ( p = 0.01 and p = 0.03, respectively). Methylation of both p15 and SHP

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::322d27a99eb584d8349cab26da98971f
https://pubmed.ncbi.nlm.nih.gov/21592569

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The ATM gene and susceptibility to childhood T-cell acute lymphoblastic leukaemia

Autor: Hirokuni Taguchi, Harry Taub, T Seriu, Jeffrey Grewal, Seisho Takeuchi, Claus R. Bartram, Koike M, Park S, Ian K. Williamson, H. Phillip Koeffler

Publikováno v: British Journal of Haematology. 103:536-538

Ataxia-telangiectasia (A-T) is a multisystem recessive disease characterized by cerebellar ataxia, oculocutaneous telangiectasias, immunodeficiency and increased risk of cancer. The ATM gene, responsible for A-T, was recently cloned at human chromoso

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bac55abe83f577944bc815538fb053d2
https://doi.org/10.1046/j.1365-2141.1998.00993.x

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T cell receptor Dδ2Dδ3 rearrangement: a suitable allele-specific marker for the detection of minimal residual disease in childhood acute lymphoblastic leukemia

Autor: Y Stark, C. R. Bartram, D. Erz, T Seriu

Publikováno v: Leukemia. 11:759-761

The applicability of T cell receptor (TCR) Ddelta2Ddelta3 junctional regions for the detection of minimal residual disease (MRD) was examined in childhood acute lymphoblastic leukemia (ALL). Southern blot analysis showed a Ddelta2Ddelta3 rearrangemen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae3416835268836edb6800a661f15a9e
https://doi.org/10.1038/sj.leu.2400643

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