Zobrazeno 1 - 10
of 1 627
pro vyhledávání: '"T Sauer"'
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-10 (2024)
Abstract AAA+ proteolytic machines unfold proteins before degrading them. Here, we present cryoEM structures of ClpXP-substrate complexes that reveal a postulated but heretofore unseen intermediate in substrate unfolding/degradation. A ClpX hexamer d
Externí odkaz:
https://doaj.org/article/30da034fd98e4f60aca290141a491821
Autor:
Alireza Ghanbarpour, Steven E. Cohen, Xue Fei, Laurel F. Kinman, Tristan A. Bell, Jia Jia Zhang, Tania A. Baker, Joseph H. Davis, Robert T. Sauer
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-10 (2023)
Abstract AAA+ proteases degrade intracellular proteins in a highly specific manner. E. coli ClpXP, for example, relies on a C-terminal ssrA tag or other terminal degron sequences to recognize proteins, which are then unfolded by ClpX and subsequently
Externí odkaz:
https://doaj.org/article/f72b46a348b247609e8481dbe950089a
Autor:
Arn T. Sauer
Gender impact assessment has been both celebrated as a beacon of hope for the cause of gender equality and criticised as being ineffectual. More than 20 years of gender mainstreaming have demonstrated that equality governance with and through impact
Autor:
Meghann R. Kasal, Hema Chandra Kotamarthi, Madeline M. Johnson, Hannah M. Stephens, Matthew J. Lang, Robert T. Sauer, Tania A. Baker
Publikováno v:
Cell Reports, Vol 42, Iss 9, Pp 113061- (2023)
Summary: Lon is a widely distributed AAA+ (ATPases associated with diverse cellular activities) protease known for degrading poorly folded and damaged proteins and is often classified as a weak protein unfoldase. Here, using a Lon-degron pair from Me
Externí odkaz:
https://doaj.org/article/9c5226e5cf5f463fae8dd0f9aa92d7bc
Publikováno v:
Hydrology and Earth System Sciences, Vol 24, Pp 3775-3788 (2020)
Vegetation plays a fundamental role not only in the energy and carbon cycles but also in the global water balance by controlling surface evapotranspiration (ET). Thus, accurately estimating vegetation-related variables has the potential to improve ou
Externí odkaz:
https://doaj.org/article/adc81cc3f88c4ce2859fd92f6ac2d2e4
Autor:
A. K. Merbach, S. Beneyto-Calabuig, J.-A. Kniffka, C. Szu-Tu, C. Rohde, M. Antes, M. Janssen, A. Waclawiczek, J. J. M. Landry, V. Benes, J. Anna, M. Brough, B. Besenbeck, J. Felden, S. Bäumer, M. Hundemer, T. Sauer, C. Pabst, M. Scherer, S. Raffel, L. Velten, C. Müller-Tidow
Publikováno v:
HemaSphere, Vol 6, Pp 329-330 (2022)
Externí odkaz:
https://doaj.org/article/34bae101bfc24b88aa68343b8a415782
Autor:
C. Schmidt, M. Janssen, P.-M. Bruch, M. F. Blank, C. Rohde, A. Waclawiczek, S. Renders, D. Heid, S. Göllner, L. Vierbaum, K. Weidenauer, S. Herbst, M. Knoll, C. Kolb, B. Besenbeck, M. Fabre, M. Gu, R. Schlenk, F. Stölzel, M. Bornhäuser, C. Röllig, U. Platzbecker, C. Baldus, H. Serve, T. Sauer, S. Raffel, C. Pabst, G. Vassiliou, B. Vick, I. Jeremias, A. Trumpp, J. Krijgsveld, C. Müller-Tidow, S. Dietrich
Publikováno v:
HemaSphere, Vol 6, Pp 354-355 (2022)
Externí odkaz:
https://doaj.org/article/33037fcd597e45c7b7f220536d15a99a
Autor:
S. Renders, A.-M. Leppä, A. Waclawiczek, C. Reyneri, M. Janssen, E. Donato, J. Unglaub, C. Pabst, R. Schlenk, M. Hundemer, S. Raffel, T. Sauer, C. Müller-Tidow, A. Trumpp
Publikováno v:
HemaSphere, Vol 6, Pp 347-348 (2022)
Externí odkaz:
https://doaj.org/article/7f424356bc1d4474a7aac02148bfeb4f
Publikováno v:
eLife, Vol 9 (2020)
AAA+ proteases perform regulated protein degradation in all kingdoms of life and consist of a hexameric AAA+ unfoldase/translocase in complex with a self-compartmentalized peptidase. Based on asymmetric features of cryo-EM structures and a sequential
Externí odkaz:
https://doaj.org/article/a60053f5c3f7400988af78e101b7ab9c
Publikováno v:
eLife, Vol 9 (2020)
When ribosomes fail to complete normal translation, all cells have mechanisms to ensure degradation of the resulting partial proteins to safeguard proteome integrity. In Escherichia coli and other eubacteria, the tmRNA system rescues stalled ribosome
Externí odkaz:
https://doaj.org/article/623a65ede5f24ec0a7f8e65a342d62ab