Zobrazeno 1 - 10
of 13
pro vyhledávání: '"T S Shoupe"'
Publikováno v:
British Journal of Pharmacology. 112:292-298
1. The effect of a single intratracheal dose (10 mg) of PF 5901 (2-[3(1-hydroxyhexyl) phenoxymethyl] quinoline hydrochloride, a specific inhibitor of the 5-lipoxygenase pathway of arachidonic acid metabolism and a leukotriene D4 antagonist) on airway
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bdd483c8b0e171cc0fca7803771232f9
https://doi.org/10.1111/j.1476-5381.1994.tb13067.x
https://doi.org/10.1111/j.1476-5381.1994.tb13067.x
Autor:
Cory M. Hogaboam, T. S. Shoupe, A. D. Befus, Elyse Y. Bissonnette, John L. Wallace, D. Donigi-Gale
Publikováno v:
British Journal of Pharmacology. 105:87-92
1. Peritoneal mast cells from rat were co-incubated in vitro in a platelet aggregometer cuvette with washed rabbit platelets. In response to stimulation with calcium ionophore (A23187; 1-5 microM), the mast cells released a substance which stimulated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9cd8cedfa89aea3a0557888956e84f2c
https://doi.org/10.1111/j.1476-5381.1992.tb14215.x
https://doi.org/10.1111/j.1476-5381.1992.tb14215.x
1. PF 10040 displaced [3H]-PAF from binding sites on rabbit platelets with an IC50 = 1.07 x 10(-5) M, which was approximately three orders of magnitude below that of a standard PAF antagonist WEB 2086 (IC50 = 4.23 x 10(-9) M). 2. PF 10040 at doses of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cddf05bf22bd8b257356d99a35136e14
https://europepmc.org/articles/PMC1910040/
https://europepmc.org/articles/PMC1910040/
Publikováno v:
Journal of lipid mediators. 7(2)
The effects and mechanism of action of PF-10040, a quinoline derivative, were examined in an experimental model of NSAID-gastritis. Oral pretreatment with PF-10040 dose-dependently reduced the severity of indomethacin-induced gastric damage, with a s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d515bb346fe9287bfe60080abeaaf072
https://pubmed.ncbi.nlm.nih.gov/8400119
https://pubmed.ncbi.nlm.nih.gov/8400119
1. The mechanisms underlying oedema formation induced in a reversed passive Arthus (RPA) reaction and, for comparison, in response to zymosan in rabbit skin were investigated. 2. Oedema formation at skin sites was quantified by the accumulation of in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::492a4806c6c48b5c4f5fb3f274507f57
https://europepmc.org/articles/PMC1907593/
https://europepmc.org/articles/PMC1907593/
Autor:
T S Shoupe, C D Hubbard
Publikováno v:
Journal of Biological Chemistry. 252:1633-1638
The kinetics of the acylation of alpha-chymotrypsin by a series of substituted phenyl p-nitrobenzoates have been studied by stopped flow and conventional spectrophotometry. Electron withdrawal in the leaving group accelerates the rate of acylation, a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::daf4c08835f3ed0950cde935e8338a13
https://doi.org/10.1016/s0021-9258(17)40596-5
https://doi.org/10.1016/s0021-9258(17)40596-5
Autor:
T S Shoupe, C D Hubbard
Publikováno v:
Enzyme. 22:130-136
A transient phase for the hydrolysis of indophenyl acetate by the commercial preparation of horse serum cholinesterase was observed on a stopped-flow spectrophotometer. It was found that the transient process is a reaction of the ester with a major c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a72000065d148f9c12336a5d52df421
https://doi.org/10.1159/000458777
https://doi.org/10.1159/000458777
Publikováno v:
Molecular pharmacology. 15(3)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2487374e44541d3fde4cf09ef4af02f3
https://pubmed.ncbi.nlm.nih.gov/226862
https://pubmed.ncbi.nlm.nih.gov/226862
Autor:
J Tan, F C Huang, P A Sonnino, J T Suh, T D Lee, M Schnapper, R J Gordon, C J Lin, W K Chan, T S Shoupe
Publikováno v:
Journal of medicinal chemistry. 32(8)
The synthesis of a series of novel substituted hydroxamates has been described along with their profile of inhibitory activity against 5-lipoxygenase, 12-lipoxygenase, and cyclooxygenase enzymes. The structure--activity relationship suggests that fut
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fabe7d7132fbc5a5a0e3e25f61ad72d
https://pubmed.ncbi.nlm.nih.gov/2502629
https://pubmed.ncbi.nlm.nih.gov/2502629
Publikováno v:
Research communications in chemical pathology and pharmacology. 19(3)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::dc0b58e5b710433b29befe464f849943
https://pubmed.ncbi.nlm.nih.gov/653112
https://pubmed.ncbi.nlm.nih.gov/653112