Zobrazeno 1 - 10
of 93
pro vyhledávání: '"T R Tephly"'
Publikováno v:
Journal of Lipid Research, Vol 29, Iss 4, Pp 501-508 (1988)
Microsomal preparations from livers of Sprague-Dawley rats catalyze the glucuronidation of 3 alpha-hydroxy-5 beta-H (3 alpha, 5 beta) short-chain bile acids (C20-C23), predominantly at the hydroxyl group, while the glucuronidation of 3 beta, 5 beta s
Externí odkaz:
https://doaj.org/article/13df6b3886754a6da567b985de0c27f9
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 28(8)
Like other basic amphiphilic drugs, the (S)-enantiomer of the antiallergic drug ketotifen exhibited biphasic kinetics when it was converted to two isomeric quaternary ammonium-linked glucuronides in human liver microsomes. For (R)-ketotifen this appl
3'-azido-3'-deoxythimidine (AZT) is glucuronidated by human UDP-glucuronosyltransferase 2B7 (UGT2B7)
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 28(5)
3'-Azido-3'-deoxythymidine (AZT) is frequently prescribed to patients infected with the human immunodeficiency virus. After absorption, AZT is rapidly metabolized into 3'-azido-3'-deoxy-5'-glucuronylthymidine by UDP-glucuronosyltransferase (UGT) enzy
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 27(10)
Although the liver has been considered the most important organ involved in glucuronidation, recent studies have focused on the role of the gastrointestinal tract in the glucuronidation of xenobiotics and endobiotics. Two UDP-glucuronosyltransferase
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 27(9)
4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone and its major metabolite, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL), are potent lung carcinogens in animals. UDP-glucuronosyltransferase (UGT)-mediated glucuronidation of NNAL is a potentially
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 26(10)
Extrahepatic glucuronidation, such as that in the central nervous system (CNS), may play a very important role in xenobiotic disposition and may serve to protect the CNS from potentially toxic xenobiotics. UDP-glucuronosyltransferase (UGT) 1A6 is an
Autor:
M D, Green, T R, Tephly
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 26(9)
Conjugation of many primary, secondary, and tertiary amine-containing xenobiotics with glucuronic acid can result in the formation of N-glucuronide metabolites. For carcinogenic arylamines and their N-hydroxylated metabolites, N-glucuronidation can r
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 26(6)
Glucuronide conjugation of xenobiotics containing a tertiary amine moiety represents a unique and important metabolic pathway for these compounds in humans. Previously, human UDP-glucuronosyltransferase (UGT) 1A4 was shown to be an important enzyme f