Zobrazeno 1 - 10
of 65
pro vyhledávání: '"T R Mosmann"'
Autor:
T R, Mosmann, R L, Coffman
Publikováno v:
Immunology today. 8(7-8)
Lymphocytes mediate many important functions of the immune system, such as antibody production, cytotoxicity, and immediate and delayed type hypersensitivity (DTH). In 1968, two major divisions of lymphocytes were recognized: B cells (derived from bo
Publikováno v:
The Journal of Immunology. 162:2477-2487
Airway inflammation associated with asthma is characterized by massive infiltration of eosinophils, mediated in part by specific chemoattractant factors produced in the lung. Allergen-specific Th2 cells appear to play a central role in asthma; for ex
Publikováno v:
The Journal of Immunology. 159:606-613
After antigenic stimulation, naive CD8+ T cells differentiate into cytotoxic Tc1 cells secreting the cytokines IL-2, IFN-gamma, and TNF, which aid their proliferation and effector functions. We have previously shown that IL-4 acts directly on differe
Publikováno v:
Diabetes. 45:1350-1357
Publikováno v:
The Journal of Immunology. 156:3166-3173
IL-13, a recently identified Th2 cytokine, shares some, but not all, IL-4 functions, including inhibition of monocyte and macrophage activation, stimulation of human B cells, and induction of growth and differentiation of mouse bone marrow cells in v
Publikováno v:
The Journal of Immunology. 156:653-662
Maternal immune responses can influence fetal survival and several cytokines have harmful or protective effects on pregnancy. The Th1 cytokines IFN-gamma and IL-2 can cause fetal loss, whereas the Th2 cytokine IL-10 is protective. However, infections
Publikováno v:
The Journal of Immunology. 156:644-652
Resolution of cutaneous leishmaniasis in infected mice is associated with a polarized Th1 immune response by the host, whereas maternal immune responses during pregnancy appear to be biased toward humoral (Th2) and away from cell-mediated (Th1) respo
Publikováno v:
The Journal of Immunology. 153:3967-3978
The Th1 group of cytokines (IL-2, IFN-gamma, and lymphotoxin (LT)) is usually associated with delayed-type hypersensitivity (DTH), whereas Th2 cytokines (IL-4, IL-5, IL-6, and IL-10) often accompany Ab production. Strong DTH and Ab responses are ofte
Publikováno v:
The Journal of Immunology. 151:4562-4573
Clinical and experimental evidence has indicated that the maternal immune response is biased toward antibody production and away from cell-mediated immunity during pregnancy, especially in the vicinity of the fetoplacental unit. Because antibody resp
Publikováno v:
The Journal of Immunology. 145:4167-4173
We identified a new cytokine, B cell-derived T cell growth factor (B-TCGF), that is produced by a murine B cell lymphoma and induces proliferation of mature and immature thymocytes in the presence of IL-2 and IL-4. Both adult and day 15 fetal thymocy