Zobrazeno 1 - 10
of 19
pro vyhledávání: '"T R J Evans"'
Autor:
Janet Graham, T. R. J. Evans, M. Highley, P. Bützberger-Zimmerli, S. Harden, E. Soulis, Martin Eatock, F. Y. Coxon, Tim Maughan, Lucy Wall, K. Boyd
Publikováno v:
BMC Research Notes
Background Advanced biliary tract carcinomas are associated with a poor prognosis, and palliative chemotherapy has only modest benefit. This multi-centre phase II study was conducted to determine the efficacy of capecitabine in combination with oxali
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ab9af505fe58ff0fffdaab423a79035
https://doi.org/10.1186/s13104-015-1778-4
https://doi.org/10.1186/s13104-015-1778-4
Autor:
B Venugopal, T R J Evans
Publikováno v:
Current Medicinal Chemistry. 18:1658-1671
Post translational modification of histones and non-histone proteins by acetylation play a key role in tumourigenesis. Histone deacetylases (HDACs) are enzymes involved in remodelling of chromatin by deacetylating the lysine residues and play a pivot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6a221509aeed50302a9dc7c37bcc279
https://doi.org/10.2174/092986711795471284
https://doi.org/10.2174/092986711795471284
Autor:
Ben P. Haynes, G. W. Halbert, M. Brampton, B. Nutley, P. Canney, T. J. Powles, L. A. Gumbrell, J. Haviland, T. R. J. Evans, M. Soukop, Helena M. Earl, Mitch Dowsett, Anthony Howell, D. W. Rea, M. Jarman, I. E. Smith, Roger Grimshaw, R. C. Coombes, S. R. D. Johnston, C. J. Twelves, Robert E. Coleman, A. Jones
Publikováno v:
Cancer Chemotherapy and Pharmacology. 53:341-348
Idoxifene is a novel selective oestrogen receptor modulator (SERM) which had greater binding affinity for the oestrogen receptor (ER) and reduced agonist activity compared with tamoxifen in preclinical studies. In a randomized phase II trial in 56 po
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::732c071ca26af2308c155a94950de380
https://doi.org/10.1007/s00280-003-0733-6
https://doi.org/10.1007/s00280-003-0733-6
Autor:
R. Blackie, N. Raby, Grant Fullarton, A. C. McDonald, G. Pentheroudakis, R. Morrison, M. Soukop, T. R. J. Evans, A. McInnes, James Paul
Publikováno v:
Annals of Oncology. 13:1469-1478
Background: The purpose of this study was to evaluate the dose-limiting toxicity (DLT) and maximum tolerated dose of capecitabine when used in combination with epirubicin and cisplatin (ECC) in patients with oesophageal or gastric adenocarcinoma. Res
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28a961153c525c643ef9c08f5dc374b9
https://doi.org/10.1093/annonc/mdf243
https://doi.org/10.1093/annonc/mdf243
Autor:
D. Bisset, J. Tabernero, T. R. J. Evans, J. Cassidy, José Baselga, Javier Sastre, Eduardo Díaz-Rubio, P. Regueiro, M. Eatock
Publikováno v:
Annals of Oncology. 13:558-565
Objectives: This phase I, dose-escalation study was conducted to determine the recommended dose of intermittent oral capecitabine in combination with a fixed dose of i.v. oxaliplatin. Secondary objectives included evaluation of the safety profile and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::008e34914c6dff218d5af4e493228f02
https://doi.org/10.1093/annonc/mdf065
https://doi.org/10.1093/annonc/mdf065
Publikováno v:
British Journal of Cancer
Thirty-nine patients with inoperable adenocarcinoma of the pancreas were studied (27 male, 12 female; median age 60 years, range 39-75 years). All patients received chemotherapy with continuous infusion 5-fluorouracil with intravenous bolus epirubici
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26040a6d6bd4ad6134c6ea84ecca10cc
https://doi.org/10.1038/bjc.1998.50
https://doi.org/10.1038/bjc.1998.50
Publikováno v:
British Journal of Cancer
Oestrone sulphatase is an important source of local synthesis of biologically active oestrogens in human breast cancer. The oestrone sulphatase enzyme in the particulate fraction of human breast carcinoma was characterised. The Km was 8.91 microM, an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::086575535e5dd6cde666a5168ff7c1bc
https://doi.org/10.1038/bjc.1994.101
https://doi.org/10.1038/bjc.1994.101
Autor:
Christopher J. Gallagher, Janine Mansi, Matthew T. Seymour, Maurice L. Slevin, P. M. Edmonds, Peter Harper, T. R. J. Evans, M. E. Gore
Publikováno v:
British Journal of Cancer
This phase II study evaluates the efficacy and toxicity of a prolonged schedule of oral etoposide in patients with measurable advanced ovarian cancer resistant to, or relapsed following, platinum-based chemotherapy. Forty-seven patients participated,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4bafb487bfb0caa9e69c5245b747e291
https://doi.org/10.1038/bjc.1994.33
https://doi.org/10.1038/bjc.1994.33
Publikováno v:
British Journal of Cancer
Oestrone sulphatase may be an important means of production of intra-tumoural oestrogens in breast cancer cells. The N-nitrosomethylurea induced rat mammary tumours, which is a good model of human breast carcinoma, was utilised to examine the signifi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8dd5134811b864d8ce445bb1fedca057
https://doi.org/10.1038/bjc.1992.13
https://doi.org/10.1038/bjc.1992.13
Autor:
T R J, Evans, W N, Keith
Publikováno v:
Minerva ginecologica. 56(6)
Rapid advances in our understanding of the molecular basis of cancer development and progression over the past 3 decades have led to the design of new potential cancer therapies based on the expression of introduced genes into a tumor or its host. In
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b59cdddc1d26a90bfdd0682edf68ea64
https://pubmed.ncbi.nlm.nih.gov/15729205
https://pubmed.ncbi.nlm.nih.gov/15729205