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Three residues in the common beta chain of the human GM-CSF, IL-3 and IL-5 receptors are essential for GM-CSF and IL-5 but not IL-3 high affinity binding and interact with Glu21 of GM-CSF

Autor: Christopher J. Bagley, G Plaetinck, Betty Zacharakis, Angel F. Lopez, S Qiyu, Joanna M. Woodcock, T R Hercus, J Tavernier

Publikováno v: The EMBO Journal. 13:5176-5185

The beta subunit (beta c) of the receptors for human granulocyte macrophage colony stimulating factor (GM-CSF), interleukin-3 (IL-3) and interleukin-5 (IL-5) is essential for high affinity ligand-binding and signal transduction. An important feature

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ffbf32265666cb5b576d9a6f78407401
https://doi.org/10.1002/j.1460-2075.1994.tb06848.x

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Specific human granulocyte-macrophage colony-stimulating factor antagonists

Autor: Joanna M. Woodcock, Mara Dottore, Christopher J. Bagley, Bronwyn Cambareri, M F Shannon, T R Hercus, Angel F. Lopez, M A Vadas

Publikováno v: Proceedings of the National Academy of Sciences. 91:5838-5842

Human granulocyte-macrophage colony-stimulating factor (GM-CSF) is a pleiotropic hemopoietic growth factor and activator of mature myeloid cell function. We have previously shown that residue 21 in the first helix of GM-CSF plays a critical role in b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f619306a972c3a71762bc3f1a8811eb
https://doi.org/10.1073/pnas.91.13.5838

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Identification of residues in the first and fourth helices of human granulocyte-macrophage colony-stimulating factor involved in biologic activity and in binding to the alpha- and beta-chains of its receptor

Autor: Joanna M. Woodcock, M F Shannon, Angel F. Lopez, Matthew A Vadas, B Cambareri, Christopher J. Bagley, M Dottore, T R Hercus

Publikováno v: Blood. 83:3500-3508

Residues within the first and fourth helices of human granulocyte- macrophage colony-stimulating factor (hGM-CSF) were analyzed for their role in biologic activity and interaction with the alpha- and beta- chains of the hGM-CSF receptor. Within the f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bc1cb143733c234b896e7cafbd7955cf
https://doi.org/10.1182/blood.v83.12.3500.3500

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Interaction of GM-CSF and IL-3 with the common beta-chain of their receptors

Autor: T R Hercus, Angel F. Lopez, M F Shannon, Joanna M. Woodcock, Christopher J. Bagley

Publikováno v: Scopus-Elsevier

Human granulocyte-macrophage colony-stimulating factor (GM-CSF) and interleukin (IL-3) are cytokines active in both normal and abnormal hemopoiesis, inflammation, and immunity. Their biological activity is mediated via receptors that comprise a ligan

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::948139a0797a11002aa27b2926992d74
https://pubmed.ncbi.nlm.nih.gov/7759954

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Extracellular Protease Production by B. Amyloliquefaciens

Autor: Brian K. May, W. H. Elliott, M. J. Bawden, T. Litjens, T. R. Hercus

Publikováno v: Extracellular Enzymes of Microorganisms ISBN: 9781468412765

B. amyloliquefaciens produces large amounts of two major secretory proteases: alkaline protease and neutral protease. Protease production by this organism is very unusual in its response to inhibitors of transcription. Using the antibiotics rifampici

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8431847dee2af226fe27122e1f8e7f9d
https://doi.org/10.1007/978-1-4684-1274-1_11

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