Zobrazeno 1 - 10
of 75
pro vyhledávání: '"T R, Walters"'
Autor:
Grace E. Woolway, Sophie E. Legge, Amy J. Lynham, Sophie E. Smart, Leon Hubbard, Ellie R. Daniel, Antonio F. Pardiñas, Valentina Escott-Price, Michael C. O’Donovan, Michael J. Owen, Ian R. Jones, James T. R. Walters
Publikováno v:
Schizophrenia, Vol 10, Iss 1, Pp 1-11 (2024)
Abstract The increasing availability of biobanks is changing the way individuals are identified for genomic research. This study assesses the validity of a self-reported clinical diagnosis of schizophrenia. The study included 1744 clinically-ascertai
Externí odkaz:
https://doaj.org/article/58b31096a7044b28aaa03e23b77da66d
Autor:
Xavier Caseras, Emily Simmonds, Antonio F. Pardiñas, Richard Anney, Sophie E. Legge, James T. R. Walters, Neil A. Harrison, Michael C. O’Donovan, Valentina Escott-Price
Publikováno v:
Translational Psychiatry, Vol 14, Iss 1, Pp 1-8 (2024)
Abstract Recent research has highlighted the role of complement genes in shaping the microstructure of the brain during early development, and in contributing to common allele risk for Schizophrenia. We hypothesised that common risk variants for schi
Externí odkaz:
https://doaj.org/article/afc3d551ce024deab2980c9a2ca7ed60
Autor:
Siobhan K. Lock, Sophie E. Legge, Djenifer B. Kappel, Isabella R. Willcocks, Marinka Helthuis, John Jansen, James T. R. Walters, Michael J. Owen, Michael C. O’Donovan, Antonio F. Pardiñas
Publikováno v:
Schizophrenia, Vol 9, Iss 1, Pp 1-8 (2023)
Abstract Clozapine is effective at reducing symptoms of treatment-resistant schizophrenia, but it can also induce several adverse outcomes including neutropenia and agranulocytosis. We used linear mixed-effect models and structural equation modelling
Externí odkaz:
https://doaj.org/article/fcf403c7194647e894e0c5a9ae9e3198
Autor:
Edward R. Palmer, Siân Lowri Griffiths, Ben Watkins, Tyler Weetman, Ryan Ottridge, Smitaa Patel, Rebecca Woolley, Sarah Tearne, Pui Au, Eleanor Taylor, Zara Sadiq, Hareth Al-Janabi, Barnaby Major, Charlotte Marriott, Nusrat Husain, Mohammad Zia Ul Haq Katshu, Domenico Giacco, Nicholas M. Barnes, James T. R. Walters, Thomas R. E. Barnes, Max Birchwood, Richard Drake, Rachel Upthegrove
Publikováno v:
Trials, Vol 24, Iss 1, Pp 1-16 (2023)
Abstract Background Depressive episodes are common after first-episode psychosis (FEP), affecting more than 40% of people, adding to individual burden, poor outcomes, and healthcare costs. If the risks of developing depression were lower, this could
Externí odkaz:
https://doaj.org/article/44f228a1a8da45fc9e082bf89cc9d09d
Autor:
Steven J. Bright, Christopher Hübel, Katherine S. Young, Shannon Bristow, Alicia J. Peel, Christopher Rayner, Jessica Mundy, Alish B. Palmos, Kirstin L. Purves, Gursharan Kalsi, Cherie Armour, Ian R. Jones, Matthew Hotopf, Andrew M. McIntosh, Daniel J. Smith, James T. R. Walters, Henry C. Rogers, Katherine N. Thompson, Brett N. Adey, Dina Monssen, Saakshi Kakar, Chelsea M. Malouf, Colette Hirsch, Kiran Glen, Emily J. Kelly, David Veale, Thalia C. Eley, Gerome Breen, Molly R. Davies
Publikováno v:
BMC Psychiatry, Vol 23, Iss 1, Pp 1-13 (2023)
Abstract Background The Genetic Links to Anxiety and Depression (GLAD) Study is a large cohort of individuals with lifetime anxiety and/or depression, designed to facilitate re-contact of participants for mental health research. At the start of the p
Externí odkaz:
https://doaj.org/article/0dd845c832e94fa4929585564fa821ee
Publikováno v:
Journal of Medical Internet Research, Vol 25, p e46675 (2023)
BackgroundPsychiatric disorders are associated with cognitive impairment. We have developed a web-based, 9-task cognitive battery to measure the core domains affected in people with psychiatric disorders. To date, this assessment has been used to col
Externí odkaz:
https://doaj.org/article/da6f204885954c8891923ddb5bb41567
Autor:
Enrico D’Ambrosio, Giulio Pergola, Antonio F. Pardiñas, Tarik Dahoun, Mattia Veronese, Leonardo Sportelli, Paolo Taurisano, Kira Griffiths, Sameer Jauhar, Maria Rogdaki, Michael A. P. Bloomfield, Sean Froudist-Walsh, Ilaria Bonoldi, James T. R. Walters, Giuseppe Blasi, Alessandro Bertolino, Oliver D. Howes
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-9 (2022)
Abstract The D2 dopamine receptor (D2R) is the primary site of the therapeutic action of antipsychotics and is involved in essential brain functions relevant to schizophrenia, such as attention, memory, motivation, and emotion processing. Moreover, t
Externí odkaz:
https://doaj.org/article/dbe39ccf3d614d2d8f15ab9ffca373c2
Autor:
Amy J. Lynham, Sarah Knott, Jack F. G. Underwood, Leon Hubbard, Sharifah S. Agha, Jonathan I. Bisson, Marianne B. M. van den Bree, Samuel J. R. A. Chawner, Nicholas Craddock, Michael O'Donovan, Ian R. Jones, George Kirov, Kate Langley, Joanna Martin, Frances Rice, Neil P. Roberts, Anita Thapar, Richard Anney, Michael J. Owen, Jeremy Hall, Antonio F. Pardiñas, James T. R. Walters
Publikováno v:
BJPsych Open, Vol 9 (2023)
Background Current psychiatric diagnoses, although heritable, have not been clearly mapped onto distinct underlying pathogenic processes. The same symptoms often occur in multiple disorders, and a substantial proportion of both genetic and environmen
Externí odkaz:
https://doaj.org/article/dd03093f092a402fbab91ae8a33de779
Autor:
C. Okhuijsen-Pfeifer, M. Z. van der Horst, C. A. Bousman, B. Lin, K. R. van Eijk, S. Ripke, Y. Ayhan, M. O. Babaoglu, M. Bak, W. Alink, H. van Beek, E. Beld, A. Bouhuis, M. Edlinger, I. M. Erdogan, A. Ertuğrul, G. Yoca, I. P. Everall, T. Görlitz, GROUP (Genetic Risk and Outcome of Psychosis) investigators, K. P. Grootens, S. Gutwinski, T. Hallikainen, E. Jeger-Land, M. de Koning, M. Lähteenvuo, S. E. Legge, S. Leucht, C. Morgenroth, A. Müderrisoğlu, A. Narang, C. Pantelis, A. F. Pardiñas, T. Oviedo-Salcedo, J. Schneider-Thoma, S. Schreiter, E. Repo-Tiihonen, H. Tuppurainen, M. Veereschild, S. Veerman, M. de Vos, E. Wagner, D. Cohen, J. P. A. M. Bogers, J. T. R. Walters, A. E. Anil Yağcıoğlu, J. Tiihonen, A. Hasan, J. J. Luykx
Publikováno v:
Translational Psychiatry, Vol 12, Iss 1, Pp 1-9 (2022)
Abstract Clozapine is the most effective antipsychotic for patients with treatment-resistant schizophrenia. However, response is highly variable and possible genetic underpinnings of this variability remain unknown. Here, we performed polygenic risk
Externí odkaz:
https://doaj.org/article/336ada6c3f194f2c90127be5920de5e1
Autor:
Elliott Rees, Hugo D. J. Creeth, Hai-Gwo Hwu, Wei J. Chen, Ming Tsuang, Stephen J. Glatt, Romain Rey, George Kirov, James T. R. Walters, Peter Holmans, Michael J. Owen, Michael C. O’Donovan
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-9 (2021)
Overlapping genes have been implicated in schizophrenia and neurodevelopmental disorders. Here, the authors overlap de novo variants in the two types of disorders and find variants in these genes with the same functional effect and in some cases the
Externí odkaz:
https://doaj.org/article/2c5e6d147085447d9cf1e2c12333d3cc