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pro vyhledávání: '"T R, Tritton"'
Autor:
T R, Tritton
Publikováno v:
Annals of the New York Academy of Sciences. 935
On the surface, higher education has served the nation well. An increasing percentage of adults have attended college. Information is widely and freely available to most citizens; the economy is steady; and technological developments appear to offer
Publikováno v:
Cancer research. 61(6)
Anthracyclines are, above all, DNA intercalators, which induce genetic damage leading to cell death. However, increasing evidence firmly suggests that the underlying mechanism for anthracycline cytotoxicity is the induction of apoptosis through intra
Publikováno v:
Oncology reports. 5(2)
We have previously shown that methotrexate (MTX) transport is impaired in murine L1210 cells selected for cisplatin (DDP) resistance (L1210/DDP) and that the decreased MTX uptake may be due to an altered 66 kDa membrane protein. We have further hypot
Publikováno v:
Cancer research. 56(23)
Asbestos fibers are human carcinogens with undefined mechanisms of action. In studies here, we examined signal transduction events induced by asbestos in target cells of mesothelioma and potential cell surface origins for these cascades. Asbestos fib
Publikováno v:
Journal of cellular biochemistry. 61(1)
We report here that the antiestrogen tamoxifen (TAM) induces cell death in human breast cancer cell line MCF-7. We assessed the type of cell death induced by TAM in this breast cancer cell line on the basis of morphological and biochemical characteri
Autor:
P J, Vichi, T R, Tritton
Publikováno v:
Cancer research. 53(21)
We present studies which suggest that the cytotoxic action of Adriamycin (ADR) may involve intracellular pathways of vesicular transport. The movement of proteins or lipids from the endoplasmic reticulum to the plasma membrane via the Golgi organelle
Autor:
P, Vichi, T R, Tritton
Publikováno v:
Cancer research. 52(15)
Adriamycin is a cytotoxic drug which has enjoyed considerable success in the treatment of cancer. This agent has a bewildering variety of biological effects both within and on the surface of cells exposed to drug, and it has proved difficult to unamb
Publikováno v:
Molecular pharmacology. 42(1)
In both mouse sarcoma 180 and human KB cells selected for the multiple drug resistance (MDR) phenotype, there is an elevation in the steady state mRNA level of c-fos. There is no detectable gene amplification for c-fos, nor is there any significant c
Autor:
T R, Tritton, J A, Hickman
Publikováno v:
Cancer cells (Cold Spring Harbor, N.Y. : 1989). 2(4)
Most approaches to cancer chemotherapy have centered around the idea that cytotoxic drugs can be used to eradicate proliferating neoplastic cells. Cytotoxicity is generally thought to evolve from the presence of drug-induced damage to the genetic mat
Publikováno v:
Biophysical chemistry. 35(2-3)
Quenching of anthracycline fluorescence by a series of spin-labeled fatty acids was used to probe the transverse location of the drug in phosphatidylcholine bilayers in the form of small unilamellar vesicles. Stern-Volmer plots of the quenching data