Zobrazeno 1 - 10 of 45 pro vyhledávání: '"T R, Shearer"'
1
Expression of calpain small subunit 2 in mammalian tissues
Autor: M. Shih, Mitsuyoshi Azuma, T. R. Shearer, Emi Nakajima, H. Ma
Publikováno v: Current eye research. 29(4-5)
The purpose of the current experiments was to more closely define the distribution and the function of calpain small subunit 2 (css2). Css2 is a newly discovered regulatory protein for the calcium activated proteases, mu- and m-calpains.Tissues from
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61eb47b19b5366e2fcfba3cae54ce218
https://pubmed.ncbi.nlm.nih.gov/15590481
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2
Characterization and expression of calpain 10. A novel ubiquitous calpain with nuclear localization
Autor: H, Ma, C, Fukiage, Y H, Kim, M K, Duncan, N A, Reed, M, Shih, M, Azuma, T R, Shearer
Publikováno v: The Journal of biological chemistry. 276(30)
Calpains are calcium-dependent intracellular nonlysosomal proteases that are believed to hydrolyze specific substrates important in calcium-regulated signaling pathways. Recently, an atypical member of the calpain family, calpain 10, was described, a
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::4dfb799878648457fbeacdefa7c93d37
https://pubmed.ncbi.nlm.nih.gov/11375982
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3
Involvement of calpain isoforms in ischemia-reperfusion injury in rat retina
Autor: Y R, Sakamoto, T R, Nakajima, C R, Fukiage, O R, Sakai, Y R, Yoshida, M R, Azuma, T R, Shearer
Publikováno v: Current eye research. 21(1)
Much evidence has accumulated suggesting that activation of calpain causes neuronal cell death in ischemic brain. However, little is known about the involvement of calpain in retinal cell death in ischemic injury. Thus, the purpose of present study w
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::07043876fed819567ecc9b7c78e77269
https://pubmed.ncbi.nlm.nih.gov/11035539
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5
Contribution of calpain Lp82-induced proteolysis to experimental cataractogenesis in mice
Autor: Y, Nakamura, C, Fukiage, M, Shih, H, Ma, L L, David, M, Azuma, T R, Shearer
Publikováno v: Investigative ophthalmologyvisual science. 41(6)
The purpose of the present experiments was to provide a biochemical mechanism for the involvement of lens-specific calpain Lp82 in experimental cataractogenesis in mice.Nuclear cataracts were produced by culturing lenses from 4-week-old mice and rats
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::85c935c978209c360d087e4f4d6890b4
https://pubmed.ncbi.nlm.nih.gov/10798663
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6
Activation of calpain in myocardial infarction: an immunohistochemical study using a calpain antibody raised against active site histidine-containing peptide
Autor: M, Kunimatsu, T, Tada, Y, Narita, Y, Ozaki, Z Q, Liu, T R, Shearer, M, Sasaki
Publikováno v: Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology. 8(1)
Tissue damage resulting from ischemia due to myocardial infarction is thought to be intensified by the proteolytic action of endogenous enzymes. Calpain (calcium dependent cysteine protease) is considered to be a highly likely candidate, since it is
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::0c1c46d65785cc64d424e92e3ab84f23
https://pubmed.ncbi.nlm.nih.gov/10722243
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7
Lp85 calpain is an enzymatically active rodent-specific isozyme of lens Lp82
Autor: H, Ma, M, Shih, I, Hata, C, Fukiage, M, Azuma, T R, Shearer
Publikováno v: Current eye research. 20(3)
To clone and sequence the cDNA for Lp85 calpain from young rat lens, and to test for Lp85 protein expression and proteolytic activity.RT-PCR and molecular cloning were performed on total RNA from 12 day-old rats. Lp85 protein expression was visualize
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::54f76602e89e24f075b2dda44894216e
https://pubmed.ncbi.nlm.nih.gov/10694893
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8
Modifications to rat lens major intrinsic protein in selenite-induced cataract
Autor: K L, Schey, J G, Fowler, T R, Shearer, L, David
Publikováno v: Investigative ophthalmologyvisual science. 40(3)
To identify modifications to rat lens major intrinsic protein (MIP) isolated from selenite-induced cataract and to determine whether m-calpain (EC 3.4.22.17) is responsible for cleavage of MIP during cataractogenesis.Cataracts were induced in rats by
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::10b5049942c133d3b675c3dc5e878bd6
https://pubmed.ncbi.nlm.nih.gov/10067969
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9
Cleavage of beta crystallins during maturation of bovine lens
Autor: M, Shih, K J, Lampi, T R, Shearer, L L, David
Publikováno v: Molecular vision. 4
(1) Identify major crystallin proteins in fetal and adult bovine lens, (2) examine the N-termini of beta-crystallins for truncation, and (3) determine if the protease m-calpain (EC 3.4.22.17) is responsible for the cleavage of bovine beta-crystallins
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::36c3566bef31de928f30191bee608a20
https://pubmed.ncbi.nlm.nih.gov/9485487
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10
Selenite nuclear cataract: review of the model
Autor: T R, Shearer, H, Ma, C, Fukiage, M, Azuma
Publikováno v: Molecular vision. 3
Selenite overdose cataract, an experimental model of nuclear cataract produced in young rats is reviewed. Topics include procedures for cataract production and assessment, metabolic and molecular changes in the epithelium of the lens, calcium accumul
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::2e2d93e53559230b016aa84fac9f9b66
https://pubmed.ncbi.nlm.nih.gov/9238097
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