Zobrazeno 1 - 10
of 28
pro vyhledávání: '"T R, Rebbeck"'
Publikováno v:
JNCI: Journal of the National Cancer Institute. 90:1225-1229
Pathways involved in androgen metabolism have been implicated in the etiology of prostate cancer. The goal of this study was to evaluate the effect of CYP3A4, a gene associated with the oxidative deactivation of testosterone, on the clinical presenta
Autor:
C M, Zeigler-Johnson, A H, Walker, B, Mancke, E, Spangler, M, Jalloh, S, McBride, A, Deitz, S B, Malkowicz, D, Ofori-Adjei, S M, Gueye, T R, Rebbeck
Publikováno v:
Human heredity. 54(1)
Ethnic differences in prostate cancer incidence are well documented, with African-Americans having among the highest rates in the world. Ethnic differences in genotypes for genes associated with androgen metabolism including SRD5A2 and CYP3A4 also ma
Autor:
T R, Rebbeck, Y, Wang, P W, Kantoff, K, Krithivas, S L, Neuhausen, A K, Godwin, M B, Daly, S A, Narod, J S, Brunet, D, Vesprini, J E, Garber, H T, Lynch, B L, Weber, M, Brown
Publikováno v:
Cancer research. 61(14)
Women who have inherited a germ-line mutation in the BRCA1 or BRCA2 (BRCA1/2) genes have a greatly increased risk of developing breast cancer compared with the general population. However, there is also substantial interindividual variability in the
Autor:
M J, Fisher, A K, Virmani, L, Wu, R, Aplenc, J C, Harper, S M, Powell, T R, Rebbeck, D, Sidransky, A F, Gazdar, W S, El-Deiry
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 7(6)
Allelic loss of chromosome 8p21-22 occurs frequently in cancer, including lung and head and neck squamous cell cancer. The tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) receptors, including proapoptotic DR4 and KILLER/DR5, are locat
Autor:
P A, Kanetsky, R, Holmes, A, Walker, D, Najarian, J, Swoyer, D, Guerry, A, Halpern, T R, Rebbeck
Publikováno v:
Cancer epidemiology, biomarkersprevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. 10(5)
The mu and theta classes of glutathione S-transferases (GST) may affect the development of cutaneous malignant melanoma (CMM) by decreasing cellular oxidative stress in skin. These isozymes are absent in a large proportion of the population because o
Publikováno v:
Cancer epidemiology, biomarkersprevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. 9(12)
It has been reported that individuals who express GSTT1, the gene coding for the theta class of the glutathione S-transferases (GSTs), have an elevated risk of prostate cancer (CaP). This result is supported by studies that show glutathione conjugati
Autor:
M J, Weiss, C, Guo, S, Shusterman, G, Hii, T L, Mirensky, P S, White, M D, Hogarty, T R, Rebbeck, D, Teare, M, Urbanek, G M, Brodeur, J M, Maris
Publikováno v:
Medical and pediatric oncology. 35(6)
Hereditary predisposition to develop neuroblastoma segregates as an autosomal dominant Mendelian trait.We have performed linkage analysis on 10 families with neuroblastoma to localize a hereditary neuroblastoma predisposition gene (HNB1).A single gen
Autor:
J M, Jaffe, S B, Malkowicz, A H, Walker, S, MacBride, R, Peschel, J, Tomaszewski, K, Van Arsdalen, A J, Wein, T R, Rebbeck
Publikováno v:
Cancer research. 60(6)
The enzyme product of SRD5A2, 5alpha-reductase type II, is responsible for converting testosterone to the more metabolically active dihydrotestosterone. Therefore, SRDSA2 may be involved in the development or growth of prostate tumors. To examine the
Autor:
T R, Rebbeck
Publikováno v:
Cancer. 86
Two classes of inherited susceptibility genes may be considered in the etiology of breast and other common cancers. First, genes have been identified that confer a high degree of breast cancer (BC) risk, usually associated with hereditary syndromes,
Autor:
T. R. Rebbeck
Publikováno v:
Journal of the National Cancer Institute. 92(1)