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Human HPRT mutant database: Software for data entry and retrieval

Autor: Neal F. Cariello, T Adams, T R Craft, Thomas R. Skopek, Harry Vrieling, A.A. van Zeeland

Publikováno v: Environmental and Molecular Mutagenesis. 20:81-83

We have developed a computer database containing information on over 1,000 human hypoxanthine guanine phosphoribosyl transferase (HPRT) mutants. Both published and unpublished data are present. The database itself is maintained in a dBASE format (.DB

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::259a1274e7ae2a62337bfcf74ca207c5
https://doi.org/10.1002/em.2850200202

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Frequency and spectrum of ethylnitrosourea-induced mutation at the hprt and lacI loci in splenic lymphocytes of exposed lacI transgenic mice

Autor: V E, Walker, N J, Gorelick, J L, Andrews, T R, Craft, J G, deBoer, B W, Glickman, T R, Skopek

Publikováno v: Cancer research. 56(20)

The development of mouse models with the endogenous hypoxanthine-guanine phosphoribosyl transferase (hprt) gene and lacI transgene as mutational targets provides an excellent opportunity to compare the mutant frequency (Mf) and types of mutations ind

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::790f7a50526d6cf3bfa56d5e4b0aa01e
https://pubmed.ncbi.nlm.nih.gov/8840980

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Toxicity, mutagenicity, and mutational spectra of N-ethyl-N-nitrosourea in human cell lines with different DNA repair phenotypes

Autor: S M, Bronstein, J E, Cochrane, T R, Craft, J A, Swenberg, T R, Skopek

Publikováno v: Cancer research. 51(19)

We examined the toxicity, mutagenicity, and mutational spectra of N-ethyl-N-nitrosourea (ENU) in three Epstein-Barr virus-transformed human lymphoblastoid cell lines, each with a different DNA repair phenotype. One cell line lacks O6-alkylguanine-DNA

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ab4f22e229b72cdec26fd1e5c0725ecb
https://pubmed.ncbi.nlm.nih.gov/1655249

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Molecular analysis of formaldehyde-induced mutations in human lymphoblasts and E. coli

Autor: T. R. Craft, Renae M. Crosby, Katherine K. Richardson, Howard L. Liber, K. B. Benforado, T.R. Skopek

Publikováno v: Environmental and molecular mutagenesis. 12(2)

The molecular nature of formaldehyde (HCHO)-induced mutations was studied in both human lymphoblasts and E. coli. Thirty HPRT/sup -/ human lymphoblast colonies induced by eight repetitive 150 ..mu..M HCHO treatments were characterized by Southern blo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::490532b315ef0a4175a86aa8435e5e12
https://pubmed.ncbi.nlm.nih.gov/2900762

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