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Akademický článek

Considerations for an In Vitro, Cell-Based Testing Platform for Detection of Adverse Drug-Induced Inotropic Effects in Early Drug Development. Part 1: General Considerations for Development of Novel Testing Platforms

Autor: Brian D. Guth, Michael Engwall, Sandy Eldridge, C. Michael Foley, Liang Guo, Gary Gintant, John Koerner, Stanley T. Parish, Jennifer B. Pierson, Alexandre J. S. Ribeiro, Tanja Zabka, Khuram W. Chaudhary, Yasunari Kanda, Brian Berridge

Publikováno v: Frontiers in Pharmacology, Vol 10 (2019)

Drug-induced effects on cardiac contractility can be assessed through the measurement of the maximal rate of pressure increase in the left ventricle (LVdP/dtmax) in conscious animals, and such studies are often conducted at the late stage of preclini

Externí odkaz: https://doaj.org/article/e6b42e00ab1d407c9c50c66883fb0686

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Akademický článek

Considerations for an In Vitro, Cell-Based Testing Platform for Detection of Drug-Induced Inotropic Effects in Early Drug Development. Part 2: Designing and Fabricating Microsystems for Assaying Cardiac Contractility With Physiological Relevance Using Human iPSC-Cardiomyocytes

Autor: Alexandre J. S. Ribeiro, Brian D. Guth, Michael Engwall, Sandy Eldridge, C. Michael Foley, Liang Guo, Gary Gintant, John Koerner, Stanley T. Parish, Jennifer B. Pierson, Mathew Brock, Khuram W. Chaudhary, Yasunari Kanda, Brian Berridge

Publikováno v: Frontiers in Pharmacology, Vol 10 (2019)

Contractility of the myocardium engines the pumping function of the heart and is enabled by the collective contractile activity of its muscle cells: cardiomyocytes. The effects of drugs on the contractility of human cardiomyocytes in vitro can provid

Externí odkaz: https://doaj.org/article/2e22341d9929407fb056d39646d70fe3

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Akademický článek

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Akademický článek

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696 Are Group and Save Samples Necessary for Common Urological Procedures?

Autor: T Parish, A Deshpande, K Mohankumar

Publikováno v: British Journal of Surgery. 108

Aim Blood tests are routinely performed as a part of pre-operative assessment (pre-op). We looked at the number of group and save (G+S) samples taken at pre-op and compared that to the number of patients needing blood transfusion having undergone com

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f8e622a9774fbd14de7c7622aaa0a337
https://doi.org/10.1093/bjs/znab259.093

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Use of the ZDF rat to model dietary fat induced hypercoagulability is limited by progressive and fatal nephropathy

Autor: Paula Katavolos, Albert E. Schultze, Jennifer B. Pierson, Marjory B. Brooks, Alan Y. Chiang, Michael K. Pugsley, Cindy E. Fishman, Stanley T. Parish

Publikováno v: Journal of pharmacological and toxicological methods. 107

Introduction: Zucker diabetic fatty (ZDF) rats are used widely as an animal model of metabolic syndrome and insulin resistance. Our study focused on the effects of high versus low dietary fat on the development of Type 2 diabetes in obese male ZDF ra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f9485b351d8154f61efaf366e6d85d1
https://pubmed.ncbi.nlm.nih.gov/33122074

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The evaluation of endpoint variability and implications for study statistical power and sample size in conscious instrumented dogs

Autor: Michael K. Pugsley, Michael J. Engwall, John Koerner, Alan Y. Chiang, Brian Guth, R. Dustan Sarazan, Jennifer Doyle, Stanley T. Parish, C. Michael Foley

Publikováno v: Journal of Pharmacological and Toxicological Methods. 92:43-51

Introduction The sensitivity of a given test to detect a treatment-induced effect in a variable of interest is intrinsically related to the variability of that variable observed without treatment and the number of observations made in the study (i.e.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2cf1ec6b17f7c64fa76c3fc94bb9c62d
https://doi.org/10.1016/j.vascn.2018.02.009

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An evaluation of the utility of LVdP/dt 40 , QA interval, LVdP/dt min and Tau as indicators of drug-induced changes in contractility and lusitropy in dogs

Autor: Dustan R. Sarazan, Peter Hoffmann, Jean-Michel Guillon, Eric I. Rossman, Jennifer Doyle, Stanley T. Parish, Brian Guth, Alan Y. Chiang, John Koerner, Michael K. Pugsley, Jennifer B. Pierson, Scott W. Mittelstadt, Michael J. Engwall

Publikováno v: Journal of Pharmacological and Toxicological Methods. 85:1-21

Introduction The importance of drug-induced effects on the inotropic state of the heart is well known. Unlike hemodynamic and cardiac electrophysiological methods, which have been routinely used in drug safety testing for years, the non-clinical asse

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b3c2f7b728d69556cae8c82df2aca66
https://doi.org/10.1016/j.vascn.2017.01.002

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