Creating a kidney organoid-vasculature interaction model using a novel organ-on-chip system

Autor: Amanda Bas-Cristóbal Menéndez, Z. Du, T. P. P. van den Bosch, A. Othman, N. Gaio, C. Silvestri, W. Quirós, H. Lin, S. Korevaar, A. Merino, J. Mulder, M. J. Hoogduijn

Publikováno v: Scientific Reports, Vol 12, Iss 1, Pp 1-11 (2022)

Abstract Kidney organoids derived from human induced pluripotent stem cells (iPSCs) have proven to be a valuable tool to study kidney development and disease. However, the lack of vascularization of these organoids often leads to insufficient oxygen

Externí odkaz: https://doaj.org/article/e76be4e67e494d13ab3d1089bfb42b3f

The mast cell: A Janus in kidney transplants

Autor: G. van der Elst, H. Varol, M. Hermans, C. C. Baan, J. P. Duong-van Huyen, D. A. Hesselink, R. Kramann, M. Rabant, M. E. J. Reinders, J. H. von der Thüsen, T. P. P. van den Bosch, M. C. Clahsen-van Groningen

Publikováno v: Frontiers in Immunology, Vol 14 (2023)

Mast cells (MCs) are innate immune cells with a versatile set of functionalities, enabling them to orchestrate immune responses in various ways. Aside from their known role in allergy, they also partake in both allograft tolerance and rejection throu

Externí odkaz: https://doaj.org/article/9fddadb5cf5a4cc5a385c49adaca02bc

Pretransplant Numbers of CD16

Autor: T P P, van den Bosch, L B, Hilbrands, R, Kraaijeveld, N H R, Litjens, F, Rezaee, D, Nieboer, E W, Steyerberg, J A, van Gestel, D L, Roelen, M C, Clahsen-van Groningen, C C, Baan, A T, Rowshani

Publikováno v: American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons. 17(10)

Acute rejection is one of the major immunological determinants of kidney graft function and survival. Early biomarkers to predict rejection are lacking. Emerging evidence reveals a crucial role for the monocyte/macrophage lineage cells in the pathoge

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c20e4d38982187fcbd22fd32a1daf3a7
https://pubmed.ncbi.nlm.nih.gov/28332287

Sequential Inhibition of PARP and BET as a Rational Therapeutic Strategy for Glioblastoma.

Autor: Peng, Xin^1,2,3 (AUTHOR), Huang, Xin^1,2 (AUTHOR), Zhang, Shaolu^1,2,4 (AUTHOR), Zhang, Naixin^1,2 (AUTHOR), Huang, Shengfan^1,2 (AUTHOR), Wang, Yingying^1,2 (AUTHOR), Zhong, Zhenxing^1,2 (AUTHOR), Zhu, Shan^1,2 (AUTHOR), Gao, Haiwang^1,2 (AUTHOR), Yu, Zixiang^1,2 (AUTHOR), Yan, Xiaotong^1,2 (AUTHOR), Tao, Zhennan⁵ (AUTHOR), Dai, Yuxiang⁵ (AUTHOR), Zhang, Zhe^1,2 (AUTHOR), Chen, Xi^6,7 (AUTHOR), Wang, Feng⁸ (AUTHOR), Claret, Francois X.³ (AUTHOR), Elkabets, Moshe⁹ (AUTHOR), Ji, Ning¹⁰ (AUTHOR) ningji@tmu.edu.cn, Zhong, Yuxu⁴ (AUTHOR) yuxuzhong2008@aliyun.com

Publikováno v: Advanced Science. 8/14/2024, Vol. 11 Issue 30, p1-16. 16p.

Creating a kidney organoid-vasculature interaction model using a novel organ-on-chip system.

Autor: Menéndez, Amanda Bas-Cristóbal^1,2 (AUTHOR) a.bas-cristobalmenendez@erasmusmc.nl, Du, Z.¹ (AUTHOR), van den Bosch, T. P. P.³ (AUTHOR), Othman, A.⁴ (AUTHOR), Gaio, N.⁴ (AUTHOR), Silvestri, C.⁴ (AUTHOR), Quirós, W.⁴ (AUTHOR), Lin, H.⁵ (AUTHOR), Korevaar, S.¹ (AUTHOR), Merino, A.¹ (AUTHOR), Mulder, J.^2,6 (AUTHOR), Hoogduijn, M. J.¹ (AUTHOR)

Publikováno v: Scientific Reports. 11/30/2022, Vol. 12 Issue 1, p1-11. 11p.