Zobrazeno 1 - 10
of 13
pro vyhledávání: '"T P, Shanley"'
Publikováno v:
Hepatology. 26:1499-1505
Kupffer cells (KCs) have been implicated in the leukocyte recruitment and microvascular dysfunction associated with liver inflammation. The overall objective of this study was to assess the role of KCs in the leukocyte adhesion and oxidative stress e
Publikováno v:
The Journal of Immunology. 154:4793-4802
The role of macrophage inflammatory protein-1 alpha (MIP-1 alpha) in the pathogenesis of acute lung injury in rats after intrapulmonary deposition of IgG immune complexes or intratracheal administration of LPS has been assessed. Critical to these stu
Publikováno v:
Shock (Augusta, Ga.). 14(4)
Previous studies demonstrated that induction of the heat shock response is associated with inhibition of the proinflammatory transcription factor NF-kappaB by a mechanism involving inhibition of I-kappaBalpha degradation. To provide further insight r
Autor:
T S, Gipson, N M, Bless, T P, Shanley, L D, Crouch, M R, Bleavins, E M, Younkin, V, Sarma, D F, Gibbs, W, Tefera, P C, McConnell, W T, Mueller, K J, Johnson, P A, Ward
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 162(6)
Inflammatory lung injury is probably regulated by the balance between proteases and protease inhibitors together with oxidants and antioxidants, and proinflammatory and anti-inflammatory cytokines. Rat tissue inhibitor of metalloprotease-2 (TIMP-2) a
Publikováno v:
Inflammation. 22(4)
Acute hemorrhagic lung injury occurs in humans with anti-GBM antibody (Goodpasture's syndrome), however, the mechanism of this injury is still largely unknown. To date, treatment has been confined to steroids and plasmaphoresis. Infusion of anti-GBM
Autor:
T P, Shanley, R L, Warner, L D, Crouch, G N, Dietsch, D L, Clark, M M, O'Brien, W M, Gallatin, P A, Ward
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 160(2)
Alpha d is a newly cloned adhesion molecule that forms a heterodimer with CD18. The requirement for alpha d in IgG immune complex-induced lung injury in rats has been evaluated by the use of blocking polyclonal and monoclonal antibodies to rat alpha
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 159(7)
Using the IgG immune complex (BSA-anti-BSA) model of acute lung injury in rats, we have compared four intratracheally administered cytokines for their protective effects on parameters of injury (albumin leak and hemorrhage) and on neutrophil accumula
Publikováno v:
The American journal of pathology. 151(1)
Interleukin-6 (IL-6) is a cytokine produced in response to a variety of inflammatory stimuli. Although IL-6 is often observed in increased amounts in acute respiratory distress syndrome, its role in the development of lung injury is unclear. The role
Autor:
K S, Kilgore, E, Schmid, T P, Shanley, C M, Flory, V, Maheswari, N L, Tramontini, H, Cohen, P A, Ward, H P, Friedl, J S, Warren
Publikováno v:
The American journal of pathology. 150(6)
Activation of the complement cascade and subsequent assembly of the membrane attack complex (MAC) occur in a number of pathophysiological settings. When formed on the surface of endothelial cells in sublytic concentrations, the MAC can induce a numbe
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 158(7)
The C-X-C chemokines of the IL-8 family possess potent chemotactic activity for neutrophils, but their in vivo role in inflammatory responses is not well understood. In the IgG immune complex-induced model of acute lung inflammatory injury in the rat